Medical Journal March 11, 2023

Published Date: 17 Mar 2023

Today's top news includes: New study finds millions of people around the world are having heart attacks after being tested for COVID-19 vaccines...

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Latest News

Woman Develops Systemic Sarcoidosis After Eyebrow Tattoo

A 46-year-old woman developed disseminated sarcoidosis after an eyebrow tattoo, with lesions spreading to distant, nontattooed skin and bilateral hilar nodes.

AF Pulsed Field Ablation Disappoints in Setup for Success

The AVANT GUARD trial design stacked the odds in favor of PFA over antiarrhythmic drugs. Yet, the results are unconvincing to this electrophysiologist. Maybe not all PFA systems are created equal.

Apr 24 2026 This Week in Cardiology

PCSK9 inhibitors in high-risk diabetes without ASCVD, the CAAN-AF trial, conduction system pacing vs biventricular pacing, PFA and stroke, and therapeutic fashion infects expert consensus are the topics John Mandrola, MD, discusses in this week's podcast.

Drug Therapy in Nonobstructive Hypertrophic Cardiomyopathy

A commentary on the first randomized trial of beta blockers vs calcium channel blockers in nonobstructive HCM that support a necessary re-evaluation of beta blockers across the spectrum of HCM.

Look Once, Think Twice: The Art of Neurologic Diagnosis

Many neurologic conditions hide behind subtle signs, and neurophobia can further confound the diagnosis. A neurologists provides tips on when to pause and think again.

Beta-Blocker Use After Myocardial Infarction: When to Stop?

New trial data question routine long term beta blocker use after myocardial infarction in stable patients with preserved function, prompting reassessment of continuation decisions.

Todays Updates

AstraZeneca to Invest $405 Million in Britain After US-UK Pharma Deal

Prime Minister Keir Starmer said on Wednesday that Britain's biggest company AstraZeneca would invest 300 million pounds ($405 ⁠million) in the country, after pausing...

Upadacitinib After TNF Inhibitor Failure Improves RA Control

In patients with active RA, switching to upadacitinib after failure of a single TNF inhibitor is more effective in reducing disease activity at 12 weeks than using a second TNF inhibitor adalimumab.

AAN 2026: Key RRMS Clinical Trial Updates

Dr Chu-Yueh Guo discusses promising MS trial results, including a study of fenebrutinib and positive safety data for ocrelizumab in pregnancy and pediatric patients.

Are Smartwatches Changing Arrhythmia Care?

Wearables can flag AF and capture symptoms in real time — but who truly benefits? Cardiologist Walid Amara, MD, outlines where smartwatches fit in clinical practice.

Why the FDA Rejected RP-1 in Melanoma: A Data Deep Dive

Dr Bishal Gyawali unpacks the FDA’s decision to deny RP-1 in melanoma, exploring why single-arm data and confounded response rates failed to meet the bar for clinical evidence.

Differential Diagnosis of Suspected Pulmonary Fibrosis and Efficacy of Approved Therapies

Experts review the differential diagnosis of suspected IPF, highlighting how a multidisciplinary approach confirmed the diagnosis and informed selection of optimal antifibrotic therapy.

‘Living’ Database Tracks Psilocybin Trials for Depression

Sypres.io continuously tracks and evaluates psychedelic research, offering an up-to date view of study findings, design, and limitations.

Todays Updates

AstraZeneca to Invest $405 Million in Britain After US-UK Pharma Deal

Prime Minister Keir Starmer said on Wednesday that Britain's biggest company AstraZeneca would invest 300 million pounds ($405 ⁠million) in the country, after pausing...

Upadacitinib After TNF Inhibitor Failure Improves RA Control

In patients with active RA, switching to upadacitinib after failure of a single TNF inhibitor is more effective in reducing disease activity at 12 weeks than using a second TNF inhibitor adalimumab.

AAN 2026: Key RRMS Clinical Trial Updates

Dr Chu-Yueh Guo discusses promising MS trial results, including a study of fenebrutinib and positive safety data for ocrelizumab in pregnancy and pediatric patients.

Are Smartwatches Changing Arrhythmia Care?

Wearables can flag AF and capture symptoms in real time — but who truly benefits? Cardiologist Walid Amara, MD, outlines where smartwatches fit in clinical practice.

Why the FDA Rejected RP-1 in Melanoma: A Data Deep Dive

Dr Bishal Gyawali unpacks the FDA’s decision to deny RP-1 in melanoma, exploring why single-arm data and confounded response rates failed to meet the bar for clinical evidence.

Differential Diagnosis of Suspected Pulmonary Fibrosis and Efficacy of Approved Therapies

Experts review the differential diagnosis of suspected IPF, highlighting how a multidisciplinary approach confirmed the diagnosis and informed selection of optimal antifibrotic therapy.

‘Living’ Database Tracks Psilocybin Trials for Depression

Sypres.io continuously tracks and evaluates psychedelic research, offering an up-to date view of study findings, design, and limitations.

Latest News

A 46-year-old woman developed disseminated sarcoidosis after an eyebrow tattoo, with lesions spreading to distant, nontattooed skin and bilateral hilar nodes.

The AVANT GUARD trial design stacked the odds in favor of PFA over antiarrhythmic drugs. Yet, the results are unconvincing to this electrophysiologist. Maybe not all PFA systems are created equal.

PCSK9 inhibitors in high-risk diabetes without ASCVD, the CAAN-AF trial, conduction system pacing vs biventricular pacing, PFA and stroke, and therapeutic fashion infects expert consensus are the topics John Mandrola, MD, discusses in this week's podcast.

A commentary on the first randomized trial of beta blockers vs calcium channel blockers in nonobstructive HCM that support a necessary re-evaluation of beta blockers across the spectrum of HCM.

Many neurologic conditions hide behind subtle signs, and neurophobia can further confound the diagnosis. A neurologists provides tips on when to pause and think again.

New trial data question routine long term beta blocker use after myocardial infarction in stable patients with preserved function, prompting reassessment of continuation decisions.

News All Time

Can AI Restore the Power of the Stethoscope?

New trials show AI can identify serious cardiac disease from heart sounds alone, yet technology only changes outcomes when clinicians trust it and use it consistently.

Erectile Dysfunction in Young Man Reveals Prolactinoma

A laboratory abnormality during the evaluation of erectile dysfunction in a young man leads clinicians to identify hyperprolactinemia and a pituitary tumor on MRI.

Incidentalomas and Anxiety in Whole-Body Screening

Dr Bishal Gyawali discusses the rising trend of whole-body scans for cancer screening and how they can cause more harm than good.

Enhancing Shared Decision-Making in Early Breast Cancer

Experts discuss communication approaches that enhance shared decision-making for patients with early breast cancer, spanning surgery, adjuvant therapy, and survivorship.

Bannwarth Syndrome in a Woman With Early Breast Cancer

The case emphasizes Bannwarth syndrome as a rare but treatable cause of neurologic deterioration in an older woman receiving surgical cancer care.

Can Large Language Models Simplify Radiology Reports?

A meta-analysis suggests that large language model-simplified radiology reports improve patient understanding and readability while preserving high accuracy and completeness.

NPH: What You Learned in Med School Is Wrong

Neurologists Indu Subramanian and Alfonso Fasano discuss normal pressure hydrocephalus and why some of the classic dogma about this condition is wrong.

Promoting Whole-Body Imaging: Not There Yet

Ethicist Art Caplan discusses marketing promotions for expensive whole-body imaging.

Medicine Will Turn Cellular Age Backward by 2050: Barzilai

Aging may not be permanent. Nir Barzilai explains how human cells reset to zero and why partial rejuvenation could be possible within decades.

Adding to the Toolbox: Thyroid Artery Embolization

Drs Kaniksha Desai and Juan Camacho discuss thyroid artery embolization.

The Time Burden of Cancer Treatment

Dr Kathy Miller discusses a recent study quantifying the hidden time burden of cancer care and its impact on clinic operations and patient experience.

ASCO GI: Updates in Pancreatic, Gastric, CRC

Dr Emil Lou highlights practice-changing updates from ASCO GI, including new immunotherapy, targeted therapy, and circulating tumor DNA advances across gastrointestinal cancers.

Study highlights AI limits in heart care

There are limits in applying AI to images of the heart, according to a new study from the Smidt Heart Institute at Cedars-Sinai published in the Journal of the American Society of Echocardiography.

New material may outperform current agents used in medical imaging

Scientists at Oregon State University have filed a patent on a design for a new magnetic resonance imaging contrast agent with the potential to outperform current agents while being less toxic to patients and more environmentally ...

High-speed imaging tracks live brain cell activity in awake mice

A research team from the School of Engineering at The Hong Kong University of Science and Technology (HKUST) has achieved a breakthrough in brain imaging by developing the world's first technology to capture high-resolution ...

New brain atlas offers unprecedented detail in MRI scans

A new AI-assisted brain atlas that can help visualize the human brain in unprecedented detail has been developed by UCL researchers, in a major step forward for neuroscience and neuroimaging.

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Why are so many young adults getting cancer?

In patients with advanced lung cancer, cemiplimab combined with chemotherapy extends life and enhances quality of life.

Novel biomarker has potential for predicting and treating skin cancer metastasis

Herpes virus-based vaccine shows promise in targeting tumors without side effects

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