Zenocutuzumab OK’d for NRG1 Fusion+ Cholangiocarcinoma

Published Date: 13 May 2026

The bispecific antibody has previously granted accelerated approval for advanced, unresectable, or metastatic non-small cell lung cancer and pancreatic adenocarcinoma harboring the gene fusions.

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In a phase 3 trial, izalontamab brengitecan shows superiority to chemotherapy in previously treated esophageal squamous cell carcinoma, but questions remain about generalizability outside China.

Changes in gut microbiome diversity are observed with certain antibiotic drugs years later, even after just one course of therapy.

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