Phase 2 Study of Lenadogene Nolparvovec Gene Therapy for Leber Hereditary Optic Neuropathy: The REVISE Trial Isabella Ciccone, MPH

Published Date: 31 Jan 2026

The REVISE trial, a phase 2 study evaluating GenSight Biologics’ lenadogene nolparvovec in patients with Leber hereditary optic neuropathy, is expected to begin in January 2026.

Read Full News

Latest News

Ocular Motor Cranial Neuropathy Tied to Parkinson’s Disease

Ocular motor cranial neuropathy is associated with an increased risk for Parkinson’s disease, a new study shows.

TBI Shows Two-Way Association With Neurologic Conditions

Traumatic brain injury is bidirectionally associated with the incidence of stroke, dementia, epilepsy, and Parkinson’s disease, a retrospective study shows.

Targeted Therapy Tied to Less Severe Auditory Hallucinations

Targeted interventions, especially avatar therapy, are associated with less severe auditory hallucinations in patients with schizophrenia, a new meta-analysis shows.

Novel, Adaptive DBS Tied to Fewer Falls in Parkinson’s

In a small feasibility study, a novel adaptive DBS system synchronized with the walking cycle has been shown to reduce the risk for falls among patients with Parkinson’s disease.

ECT Tied to Delayed Schizophrenia Rehospitalizations

Electroconvulsive therapy (ECT) is associated with longer time to hospital readmission or suicide compared to non-ECT treatment in patients with schizophrenia, a study shows.

Sleep Disorders May Raise Risk for Sudden Death in Epilepsy

Comorbid primary sleep disorders are tied to higher risk for sudden unexpected death, all-cause mortality, and accidents in patients with epilepsy, a new study finds.

Todays Updates

Enhancing Comprehensive Biomarker Testing and Biomarker-Directed Treatment Selection

Advancing Care in ES-SCLC: Personalized Strategies, New Therapies, and Real-World Insights

Adjuvant Combination for Kidney Cancer Gets FDA's Blessing

Belzutifan and pembrolizumab together reduced the risk of disease recurrence or death

FDA Approves Prostate Cancer Combo That Warranted Advisory Meeting

Capivasertib plus abiraterone combination lands indication for PTEN-deficient tumors

Talquetamab Regimens Boost Survival in Multiple Myeloma

"Combinations represent additional options for early-line treatment," researcher says

In High-Risk B-Cell ALL, Swapping Out Chemo for Blinatumomab Improves Outcomes

The bispecific T-cell engager also reduced toxicity in newly diagnosed kids

Timely 'Nudges' Can Help Encourage More End-of-Life Conversations in Cancer

A combination of clinician and patient prompts worked best, but talks remained infrequent

Todays Updates

Enhancing Comprehensive Biomarker Testing and Biomarker-Directed Treatment Selection

Advancing Care in ES-SCLC: Personalized Strategies, New Therapies, and Real-World Insights

Adjuvant Combination for Kidney Cancer Gets FDA's Blessing

Belzutifan and pembrolizumab together reduced the risk of disease recurrence or death

FDA Approves Prostate Cancer Combo That Warranted Advisory Meeting

Capivasertib plus abiraterone combination lands indication for PTEN-deficient tumors

Talquetamab Regimens Boost Survival in Multiple Myeloma

"Combinations represent additional options for early-line treatment," researcher says

In High-Risk B-Cell ALL, Swapping Out Chemo for Blinatumomab Improves Outcomes

The bispecific T-cell engager also reduced toxicity in newly diagnosed kids

Timely 'Nudges' Can Help Encourage More End-of-Life Conversations in Cancer

A combination of clinician and patient prompts worked best, but talks remained infrequent

Latest News

Ocular motor cranial neuropathy is associated with an increased risk for Parkinson’s disease, a new study shows.

Traumatic brain injury is bidirectionally associated with the incidence of stroke, dementia, epilepsy, and Parkinson’s disease, a retrospective study shows.

Targeted interventions, especially avatar therapy, are associated with less severe auditory hallucinations in patients with schizophrenia, a new meta-analysis shows.

In a small feasibility study, a novel adaptive DBS system synchronized with the walking cycle has been shown to reduce the risk for falls among patients with Parkinson’s disease.

Electroconvulsive therapy (ECT) is associated with longer time to hospital readmission or suicide compared to non-ECT treatment in patients with schizophrenia, a study shows.

Comorbid primary sleep disorders are tied to higher risk for sudden unexpected death, all-cause mortality, and accidents in patients with epilepsy, a new study finds.

News All Time

Brief Brain Stimulation Effective for Depression in PD

Intermittent theta-burst stimulation matches the efficacy of standard transcranial magnetic stimulation for depression in Parkinson’s disease but with a shorter treatment time, new research shows.

AD Biomarkers Tied to Worse Cognition in Midlife Adults

Alzheimer’s disease pathology, measured by amyloid and tau blood biomarkers, can appear in midlife and is associated with worse cognitive performance years before dementia onset.

Lumateperone Linked to Lower Risk for Schizophrenia Relapse

Lumateperone was associated with a 63% lower risk for relapse and was well-tolerated among patients with schizophrenia.

CMS Rule Misses Mark on CPAP Adherence

A Kaiser Permanente study shows some people who initially struggle with CPAP adherence still use the device at 1 year, suggesting CMS’ 90-day cutoff is too strict.

New Imaging Agent Could Speed Detection of AD-Related Tau

A novel PET imaging agent identified AD-related tau earlier and in more patients than the currently used tracer, possibly speeding AD detection, a new study shows.

Federally Funded Research Backs Tighter Drinking Limits

A federally funded review conducted to inform US dietary advice supports a one-drink-per-day limit for all adults — a stricter recommendation than current federal guidance.

Melatonin Gummies Blur Line Between Medicine and Candy

Pediatricians call for a ban on melatonin gummy bears and similar products, warning that candy-like supplements may encourage unsupervised use in children.

A New Option for Headache?

Findings come from a single-center study suggest the non-opioid suzetrigine may help reduce pain in multiple headache types, but more research is needed.

NfL a Biomarker for Cognitive Function in Patients With MS?

New data offer strong evidence that neurofilament light chain (NfL) levels could be an accurate biomarker for monitoring cognitive function in MS.

Most ‘Sleep-Divorced’ Couples Support Sleeping Separately

A study in Brazil reveals the prevalence and attitudes among couples not driven by relationship stress toward ‘sleep divorce’ arrangements.

Experimental Drug Cuts Migraine Days in Mid-stage Trial

Denmark's Lundbeck said on Thursday its experimental drug bocunebart cut monthly migraine days in ⁠a mid-stage study, supporting further development of a new type of...

Spinal Cord Treatment Triggers Hope and Lawsuits in Brazil

An experimental treatment for spinal cord injuries is drawing patients from as far as Mexico, mobilizing the government to expedite approval before its safety has been proven in a clinical trial.

HTTP error: 503

Comorbid Illness Common in Functional Neurologic Disorder

Functional neurologic disorder has a higher mortality rate than multiple sclerosis and often occurs with comorbid neurologic and psychiatric disorders, a new study shows.

HTTP error: 503

Primary Care Making More Mental Health Diagnoses for Kids

Pediatric mental health visits in primary care surged over a 9-year period.

Phase 2 Study of Lenadogene Nolparvovec Gene Therapy for Leber Hereditary Optic Neuropathy: The REVISE Trial Isabella Ciccone, MPH

Latest News

Ocular Motor Cranial Neuropathy Tied to Parkinson’s Disease

TBI Shows Two-Way Association With Neurologic Conditions

Targeted Therapy Tied to Less Severe Auditory Hallucinations

Novel, Adaptive DBS Tied to Fewer Falls in Parkinson’s

ECT Tied to Delayed Schizophrenia Rehospitalizations

Sleep Disorders May Raise Risk for Sudden Death in Epilepsy

Todays Updates

Enhancing Comprehensive Biomarker Testing and Biomarker-Directed Treatment Selection

Advancing Care in ES-SCLC: Personalized Strategies, New Therapies, and Real-World Insights

Adjuvant Combination for Kidney Cancer Gets FDA's Blessing

FDA Approves Prostate Cancer Combo That Warranted Advisory Meeting

Talquetamab Regimens Boost Survival in Multiple Myeloma

In High-Risk B-Cell ALL, Swapping Out Chemo for Blinatumomab Improves Outcomes

Timely 'Nudges' Can Help Encourage More End-of-Life Conversations in Cancer

Todays Updates

Enhancing Comprehensive Biomarker Testing and Biomarker-Directed Treatment Selection

Advancing Care in ES-SCLC: Personalized Strategies, New Therapies, and Real-World Insights

Adjuvant Combination for Kidney Cancer Gets FDA's Blessing

FDA Approves Prostate Cancer Combo That Warranted Advisory Meeting

Talquetamab Regimens Boost Survival in Multiple Myeloma

In High-Risk B-Cell ALL, Swapping Out Chemo for Blinatumomab Improves Outcomes

Timely 'Nudges' Can Help Encourage More End-of-Life Conversations in Cancer

Latest News

News All Time

Brief Brain Stimulation Effective for Depression in PD

AD Biomarkers Tied to Worse Cognition in Midlife Adults

Lumateperone Linked to Lower Risk for Schizophrenia Relapse

CMS Rule Misses Mark on CPAP Adherence

New Imaging Agent Could Speed Detection of AD-Related Tau

Federally Funded Research Backs Tighter Drinking Limits

Melatonin Gummies Blur Line Between Medicine and Candy

A New Option for Headache?

NfL a Biomarker for Cognitive Function in Patients With MS?

Most ‘Sleep-Divorced’ Couples Support Sleeping Separately

Experimental Drug Cuts Migraine Days in Mid-stage Trial

Spinal Cord Treatment Triggers Hope and Lawsuits in Brazil

Comorbid Illness Common in Functional Neurologic Disorder

Primary Care Making More Mental Health Diagnoses for Kids

Recommended News For You

In Sickle Cell Disease, Lovo-Cel is "Life-Changing, Transformative.".

Why Did Rare Cancer Shrink on Its Own?

Are patients with advanced cancer receiving treatment aligned with their goals?

EU Adds CAR-T Warning; New Blincyto Indication; Good News in Pancreatic Cancer

Acupuncture may alleviate nocturia in men treated for prostate cancer

Opposition to the Surgical Lymph Node Sampling Rule for Lung Resection.

Colorectal Cancer Screening Uptake Tripled in 45-49 Age Group

Recommended Articles For You

An Introduction To The CA 15-3 Tumor Marker Test For Cancer Patients

Managing High Potassium Levels: A Comprehensive Guide to Veltassa

Lentigo Maligna Melanoma: Everything You Need To Know about This Skin Cancer

Treating Oral Fibromas: Options and Guidelines for a Healthier Mouth

Whats more on Hidoc Dr.

Medical Updates

KOL Videos

Surveys

Events

Featured News

Featured Articles

Featured Events

Featured KOL Videos

Quick Links

Verification

Welcome to Hidoc Dr.