Global Trial to Test Lifestyle Plus Metabolic Tx in Dementia

Published Date: 22 Jul 2026

A $100 million global trial will investigate whether adding a metabolism-targeting therapy to multidomain lifestyle intervention further reduces the risk of cognitive decline in older adults at risk for dementia.

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Latest News

In patients with obesity and knee osteoarthritis eligible for knee arthroplasty, an intensive dietary weight-loss program is clinically inferior to surgery for patient-reported pain and function.

Incretin mimetic therapy for obesity may reduce muscle mass and bone mineral density, but its effects on physical function and the risk for fractures in older adults remain uncertain.

An increase in dietary spermidine intake over 1 year is associated with improvements in hepatic function and cardiometabolic health in older adults with overweight or obesity and metabolic syndrome.

Ultrasound imaging reveals structural changes in the vagus nerve of patients with Parkinson's disease in a meta-analysis.

Using both SGLT2 inhibitors and GLP-1 receptor agonists is no more effective than using either drug alone in patients with type 2 diabetes, a new meta-analysis suggests.

A mindfulness-based eating intervention improved anxiety, depression, and eating behaviors in adults with obesity and generalized anxiety disorder.

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Alcohol and Marijuana Use in Type 1 Diabetes: What to Know

People with type 1 diabetes are just as likely to use substances as the rest of the population, so they need to be aware of the risks and how to mitigate them.

Semaglutide Tied to Lower Risk for Adult-Onset Seizure

In adults with type 2 diabetes, semaglutide initiation was associated with roughly half the risk for adult-onset seizure compared with other glucose-lowering medications — a protective effect that appeared independent of blood sugar or weight control.

Once-Daily Prednisolone Shows Promise for Hypoadrenalism

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Kidney Disease Hits Early, Hard in Kids With Spina Bifida

A population-based study finds that children with spina bifida are more likely than their peers in the general population to develop chronic kidney disease and ESRD — and to do so at younger ages.

Visceral Belly Fat Can Make You Age Faster, Experts Warn

Higher visceral fat is linked to accelerated biological aging in middle-aged adults, independent of other adiposity measures and lifestyle factors.

India Approves Novo Nordisk's Obesity Drug Wegovy for Fatty Liver Disease

Danish drugmaker Novo Nordisk said on Friday that India's drug regulator has approved its ⁠obesity drug Wegovy for the treatment of metabolic dysfunction-associated...

Glucocorticoid Use in Giant Cell Arteritis Remains High

Despite efforts to reduce glucocorticoid exposure in GCA, patients diagnosed in 2022 still received high doses — and even low-dose exposure was associated with adverse outcomes.

GLP-1s May Reduce Overdose Risk, Even After Discontinuation

People with a history of alcohol, opioid, or substance overdose who are later started on GLP-1 medications have a significantly lower risk for a repeat overdose.

Does High Cortisol Shut Down GLP-1s?

Claims circulating on social media warn that high cortisol levels can block the weight-loss effects of GLP-1, but obesity medicine experts say there is no evidence to support the idea.

Managing Diabetes and HIV Together: What to Know

As people with HIV live longer, diabetes is becoming an increasingly important contributor to morbidity and mortality, requiring specialized management approaches.

South Africa's IDexis Appeals Court Ruling Over Compounded Weight-loss Drugs

South African pharmacy group iDexis said on Tuesday it had applied to appeal a court judgment that curbed its production ⁠of compounded weight-loss medicines, disputing...

Study Flags Need to Monitor Frailty Risks With GLP-1 Drugs for Older Adults

Potential signs of frailty in older adults taking Eli Lilly’s GLP-1 obesity drug Zepbound may signal relatively high risks for adverse outcomes, according to a large study...

Merck Gets US FDA Nod for First-in-its-class Oral Cholesterol Drug

The U.S. FDA approved Merck's cholesterol-lowering pill, it said on Thursday, the first in a class of drugs dominated ⁠by injections, which could potentially broaden the use...

Do Infant Food Portion Sizes Matter for Later Overweight?

Larger food portions during complementary feeding are associated with higher odds of overweight in both early and later childhood.

Screening for Diabetes at Urgent Care Could Save Lives

Millions of Americans have diabetes or prediabetes. Simple screening at urgent care could change their futures.

Semaglutide Linked to Rare Brain Illness

In rare cases, semaglutide for obesity is linked to Wernicke encephalopathy, driven by gastrointestinal intolerance, reduced nutritional intake, and rapid weight loss leading to thiamine deficiency.

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