GIP receptor shows surprising dual action: Both activation and blockade support weight loss

Published Date: 30 Apr 2025

Drugs that bind to and activate the receptors for the hormones GLP-1 and GIP are effective in the treatment of obesity and diabetes. Surprisingly, active substances are currently being developed that not only activate the ...

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Semaglutide and tirzepatide use is rising among patients with rheumatic and musculoskeletal diseases and is linked to meaningful 1-year weight loss, especially in tirzepatide users.

The Fracture Risk Assessment Tool predictions suggest patients who don’t meet guideline criteria for parathyroidectomy may nevertheless benefit from the surgery.

Specific serum acylcarnitine levels are linked to faster kidney function decline in type 2 diabetes and can help improve the prediction of patients at highest risk for rapid decline.

Modeling finds marked early weight loss with tirzepatide that later plateaus as appetite returns and energy expenditure decreases, and discontinuation of the drug is linked to partial weight regain.

Emerging evidence suggests some sugar substitutes may affect metabolism, gut microbiome, and cardiovascular health more than previously recognized.

Weight bias, stigma, and discrimination are linked to poorer mental health and weight outcomes after bariatric surgery, although the long-term physical effects remain understudied.

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