Sleep deprivation is associated with risk of atherosclerosis in adults: JAHA

Published Date: 17 Feb 2023

United States: Infrequent sleep, particularly chronic sleep, in adults aged 45 and older is associated with numerous measures of...

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CKM Syndrome Tied to Major Blinding Eye Diseases

Cardiovascular-kidney-metabolic syndrome is associated with an increased risk of developing major blinding eye diseases in a large UK cohort, with stage 3 showing the highest rates.

Is DTG/3TC Comparable to Triple Therapy in High Viral Load?

Dolutegravir/lamivudine shows comparable virologic suppression to bictegravir/emtricitabine/tenofovir alafenamide in HIV with very high viral loads, with no significant difference between the regimens.

Usual Tests May Miss Risks in Mild Pulmonary Hypertension

In patients with mild pulmonary hypertension, measures of pulmonary artery stiffness and right-ventricular function may predict survival better than traditional measures do.

Late Bleeding Events After PCI Tied to Higher Death Risk

After PCI, both ischaemic and bleeding complications are tied to a higher risk for death, but bleeding events occurring months after discharge carry a higher risk for death than late ischaemic events.

1-Year Tirzepatide, Ixekizumab Combo Trial Results Reported

Results from phase 3b trials show a greater benefit at 52 weeks for patients with psoriasis or psoriatic arthritis treated with ixekizumab plus tirzepatide vs ixekizumab alone.

Certain Social Factors Tied to Metabolic Liver Disease

Food insecurity and neighborhood deprivation were each independently associated with higher incidence of MASLD, with the highest incidence among adults experiencing both.

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Can 80 Gy Radiation Boost Survival in Prostate Cancer?

A modest increase in radiation dose improves progression-free survival over 10 years among men with high-risk prostate cancer — but the overall survival benefits found in a French trial are uncertain.

Todays Updates

Can 80 Gy Radiation Boost Survival in Prostate Cancer?

A modest increase in radiation dose improves progression-free survival over 10 years among men with high-risk prostate cancer — but the overall survival benefits found in a French trial are uncertain.

Latest News

Cardiovascular-kidney-metabolic syndrome is associated with an increased risk of developing major blinding eye diseases in a large UK cohort, with stage 3 showing the highest rates.

Dolutegravir/lamivudine shows comparable virologic suppression to bictegravir/emtricitabine/tenofovir alafenamide in HIV with very high viral loads, with no significant difference between the regimens.

In patients with mild pulmonary hypertension, measures of pulmonary artery stiffness and right-ventricular function may predict survival better than traditional measures do.

After PCI, both ischaemic and bleeding complications are tied to a higher risk for death, but bleeding events occurring months after discharge carry a higher risk for death than late ischaemic events.

Results from phase 3b trials show a greater benefit at 52 weeks for patients with psoriasis or psoriatic arthritis treated with ixekizumab plus tirzepatide vs ixekizumab alone.

Food insecurity and neighborhood deprivation were each independently associated with higher incidence of MASLD, with the highest incidence among adults experiencing both.

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Edoxaban Falls Short After Intracranial Hemorrhage in AF

Edoxaban reduced ischemic stroke after intracranial hemorrhage in patients with AF, but excess hemorrhagic stroke and major bleeding offset the benefit.

Tailored Approach Shortens Endocarditis Therapy

Tailored antibiotic therapy for infective endocarditis was associated with a significant reduction in treatment duration, according to an open-label multicenter trial.

Atorvastatin Cuts Major CV Events by 30% in Older Adults in STAREE

Statin use for primary cardiovascular prevention in adults aged 70 years or older is supported by data from STAREE, although treatment did not prolong disability-free survival.

Milvexian Fails to Reduce CV Events After ACS

Patients in the phase 3 LIBREXIA ACS trial showed no reduction in cardiovascular events after acute coronary syndrome.

Phase 3 Eplontersen Trial Results Disappoint

Despite a major reduction in transthyretin amyloid deposits, eplontersen, a drug that reduces TTR production, did not reduce events associated with TTR amyloidosis in a phase 3 trial.

Heart Failure Drug May Not Improve Exercise Fitness in nHCM

A heart failure drug combination may not improve exercise capacity in patients with nonobstructive hypertrophic cardiomyopathy but is associated with favorable cardiac structural remodeling.

DOACs Benefit AF Patients With Intermediate Stroke Risk

Anticoagulation reduced adverse clinical events in patients with atrial fibrillation at intermediate stroke risk, without an apparent increase in major bleeding.

Mounjaro FDA-Approved to Reduce Cardiovascular Risk in T2D

Lilly's Mounjaro (tirzepatide) is now approved to reduce cardiovascular risk in adults with type 2 diabetes.

Weight Down, Steps Down: The GLP-1 Catch

Studies suggest that strong recommendations for exercise with GLP-1s are commonly not heeded; possible reasons vary.

Ginseng, the ‘Miracle Root’: How Strong Is the Evidence?

Evidence varies across ginseng uses, with some potential benefits but limited support for treating fatigue, cognitive decline, infections, diabetes, or cardiovascular disease.

Inpatient Weight Loss May Cut HF Rehospitalization Risk

Losing weight during hospitalization for heart failure in patients treated with intravenous loop diuretics is associated with a reduced 30-day risk for rehospitalization.

Common Lipid-Lowering Drug May Slow Diabetic Eye Damage

A common lipid-lowering drug is tied to markedly lower odds of vision-threatening retinopathy, cataracts, and macular edema in patients with mild or moderate nonproliferative diabetic retinopathy.

What Is Fibermaxxing and Is More Fiber Always Better?

Higher-fiber intake is linked to important health benefits; however, benefits appear to plateau at moderate intake, whereas excessive amounts can cause gastrointestinal symptoms.

Diabetes Linked to Higher Risk for Sudden Cardiac Death

Diabetes may independently raise the risk for sudden cardiac death, regardless of obstructive coronary artery disease status.

Sleep Apnoea Tied to Heart Rhythm Risk in Dialysis Patients

Patients undergoing peritoneal dialysis who have sleep apnoea — particularly those older than 60 years — face an increased risk for new-onset atrial fibrillation, a Finnish study finds.