ANTHEM-HFrEF: What Can We Learn From an Unfinished Trial?

Published Date: 13 Jun 2026

Despite early termination, the ANTHEM-HFrEF trial holds important lessons for investigators.

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Functional angiography is linked to a 38% lower risk for the primary outcome over conventional angiography in STEMI patients with multivessel disease.

Large cohort study shows sweet spot at 1-3 g/dL above the WHO threshold.

Children with prosthetic valve endocarditis present at an older age and show lower echocardiographic detection than those with native valve disease; complications and surgery are highly frequent.

Intra-amniotic infection is associated with early-onset neonatal sepsis in pregnancies complicated by preterm prelabor rupture of membranes.

It is nearly 20 years since trials of prasugrel and ticagrelor showed better protection over clopidogrel against MACE for ACS, but superiority of one over the other still remains unresolved.

In perimenopausal and recently postmenopausal women experiencing hot flashes and/or night sweats, initiating hormone therapy is associated with a reduction in the risk for cardiovascular events.

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