S2 Part 1: Processing and minor processing

Published Date: 16 Feb 2023

Dr. Jacob Sands and Dr. Jared Weiss talk about subtypes. ongoing clinical trials; sustained sustained response to treatment; And it is possible to use the word "cure" to treat a small breast cancer.

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S1 Episode 2: Can Early Genetic Testing Change ATTR-CM Outcomes?

Drs Kevin Alexander and Joban Vaishnav explore when and how to use genetic testing in ATTR-CM, why distinguishing hereditary from wild-type disease matters, and what this means for patients' families.

S1 Episode 1: Rethinking Rhythm Control in ATTR-CM

Is rhythm control underused in ATTR-CM? Drs Kevin Alexander and Ronald Witteles make the case for rethinking how we manage arrhythmias in this disease.

Chest Plaque Reveals Dermatofibrosarcoma in a Man

Dermatofibrosarcoma protuberans can masquerade as a benign plaque — this case requires biopsy of a 10 × 8 cm anterior chest lesion to confirm spindle cell sarcoma and guide curative surgical excision.

New ‘Breathing’ Lung-On-Chip Surprises Against Tuberculosis

Four types of lung cells — including immune cells — function together on a chip environment that simulates respiration and inhibits tuberculosis growth.

S2 Episode 6: PCR in Breast Cancer and HER2

Drs Kathy Miller and Lajos Pusztai discuss predicting which patients will have a PCR, and the impact this has on new treatments or reducing the intensity of treatments.

Therapeutic Drug Monitoring Widely Variable in Ped Rheum

In a survey, pediatric rheumatologists cite a lack of training, lack of data, turnaround time, and lab timing as barriers to broader use.

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Novel Psychedelic Promising on Resistant Depression

An investigative inhaled formulation of the psychedelic mebufotenin is linked to significant improvements in depression symptoms compared to placebo, a phase 2b trial shows.

Biocomputer From Human Neurons Plays Doom, Raises Ethics

A biological computer using human neurons learns Doom within 1 week, highlighting rapid adaptive learning and potential advantages over traditional AI systems.

Adding Chemo to Osimertinib Doubles PFS in Advanced NSCLC

The findings could fill a treatment gap for patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC) who also carry TP53 mutations.

EMA OKs Two Treatments for Small Cell Lung Cancer

Both drugs increase overall and progression-free survival.

Todays Updates

Novel Psychedelic Promising on Resistant Depression

An investigative inhaled formulation of the psychedelic mebufotenin is linked to significant improvements in depression symptoms compared to placebo, a phase 2b trial shows.

Biocomputer From Human Neurons Plays Doom, Raises Ethics

A biological computer using human neurons learns Doom within 1 week, highlighting rapid adaptive learning and potential advantages over traditional AI systems.

Adding Chemo to Osimertinib Doubles PFS in Advanced NSCLC

The findings could fill a treatment gap for patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC) who also carry TP53 mutations.

EMA OKs Two Treatments for Small Cell Lung Cancer

Both drugs increase overall and progression-free survival.

Latest News

Drs Kevin Alexander and Joban Vaishnav explore when and how to use genetic testing in ATTR-CM, why distinguishing hereditary from wild-type disease matters, and what this means for patients' families.

Is rhythm control underused in ATTR-CM? Drs Kevin Alexander and Ronald Witteles make the case for rethinking how we manage arrhythmias in this disease.

Dermatofibrosarcoma protuberans can masquerade as a benign plaque — this case requires biopsy of a 10 × 8 cm anterior chest lesion to confirm spindle cell sarcoma and guide curative surgical excision.

Four types of lung cells — including immune cells — function together on a chip environment that simulates respiration and inhibits tuberculosis growth.

Drs Kathy Miller and Lajos Pusztai discuss predicting which patients will have a PCR, and the impact this has on new treatments or reducing the intensity of treatments.

In a survey, pediatric rheumatologists cite a lack of training, lack of data, turnaround time, and lab timing as barriers to broader use.

News All Time

Staying the Course After EGFR Progression

Dr Mark Kris highlights a recent study on osimertinib in NSCLC and outlines the best approaches for treatment beyond progression.

AI in Medicine Desperately Needs Less Hype and More Honesty

A Yale School of Medicine professor argues that total transparency is the only way AI can become a trustworthy tool for physicians and patients.

When Patients Feel Unheard: The Communication Gap in Care

Dr Mark Lewis discusses a recent social-media post which led to a reflection on how physicians can actively listen to patients and facilitate shared decision making.

Gastric Cancer: Focused Screening, Better Outcomes

Early detection saves lives in gastric cancer, but in Western settings the key lies in risk stratification, Helicobacter pylori eradication, and high-quality endoscopy.

Tethered to Tech, Nurses Suffer Digital Compassion Fatigue

The explosion of telehealth, remote monitoring, and screen-based charting is leading to digital compassion fatigue for nurses.

What Happened to the Prestige of Being a Doctor?

‘Back in the day’ butts heads with ‘medicine today.’ A candid look at why physicians may never have the authority, respect, and trust doctors enjoyed 50 years ago.

When Saying Less Helps in Primary Care Consultations

According to experts, primary care physicians may improve listening and therapeutic relationships by deliberately using silence during consultations.

Why Med Students Think They’re Dying (When They’re Not)

Studying disease amid the stress of medical school can make every headache a tumor and every muscle twitch ALS. Welcome to ‘med school syndrome.’ Try not to panic.

When the Doctor Needs a Checkup

Researchers have documented a gradual decline in physicians’ cognitive abilities starting in their mid-sixties.

Just 1 in 8 Nurses Would Recommend the Profession

Only 12% of UK nurses would recommend their profession — despite most reporting job satisfaction — as harassment, discrimination, and workload pressures take a toll.

Preventing Burnout in Clinical Practice

Perfectionism, empathy, and blurred boundaries — together with workload, staff shortages, and constant connectivity — create a high risk for stress for clinicians.

Death Rates Higher With ‘Alternative’ Cancer Therapies

Complementary and alternative medicine is more popular than ever, but does it help or hinder conventional cancer treatment?

S2 Episode 5: HER2 Low Testing in the ADC Era

Drs Kathy Miller and Sunil Badve discuss how HER2 testing has evolved over time as the need for that clinical testing has shifted, including assay limits, biology, and clinical impact.

HF With Improved Ejection Fraction

Heart Failure with Improved ejection fraction is characterized by previously reduced left ventricular ejection fraction (≤40%) that subsequently improves to >40%. This review highlight existing clinical gaps and proposes future research directions to refine risk stratification and therapeutic approaches for this evolving HF population.

S2 Episode 6: A Futuristic Vision for Treating Myelofibrosis

What will the next decade bring for myelofibrosis care? Drs Jain and Pemmaraju explore futuristic therapies, earlier interventions, and smarter diagnostics.

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