May 15 2026 This Week in Cardiology

Published Date: 16 May 2026

Another positive digoxin trial, another classic coronary physiology study from Imperial College London (ORBITA-FIRE), news in hypertrophic cardiomyopathy, and TAVR done in the wrong patients are the topics John Mandrola, MD, discusses in this week’s podcast.

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Latest News

Nothing to Shrug About: Shoulder Reproducibility with SGRT

A pilot study suggests open-face SGRT immobilization is feasible for HN radiotherapy, with shoulder reproducibility similar to conventional masks.

Paget's Disease Mimicking Metastasis: A Diagnostic Pitfall

A case of rising PSA and widespread sclerotic bone lesions turned out to be Paget's disease, not metastasis—avoiding unnecessary ADT and bone harm.

Efficacy of Lu177-PSMA in Pretreated Older Veterans

Lutetium177-PSMA-617 is a radioligand therapy for PSMA-positive metastatic castrate resistant prostate cancer after receipt of at least 1 ARPI.

Care Coordination for Evaluation of Possible Malignancy

VHA Directive 1415 mandates that all VA systems implement formal, documented processes with clear roles to manage suspected cancer cases.

S1 Episode 2: Seeing Gout Clearly: Advances in Diagnosis and Imaging

Drs Kenneth Saag and Nicola Dalbeth explore how crystal analysis and imaging advances can sharpen gout diagnosis and guide patient care.

Common Causes of Vertigo in Primary Care: Part 3

Clinicians should be prepared to identify vestibular migraine, the rare Ménière disease, and persistent postural perceptual dizziness, a functional disorder.

Todays Updates

UK Lawmakers Reject Bid to Legalise Assisted Dying

British lawmakers rejected on Friday a proposal to legalise assisted dying for terminally ill people, dealing a major setback to campaigners and bringing the latest effort...

Liberalized Cannabis Policies May Increase Substance Use

In a global review, legalization was associated with increased cannabis use and related emergency department visits, with potential decreases in the use of alcohol and tobacco.

Tissue-Free ctDNA Predicts Recurrence in Early Breast Cancer

Researchers analyzed plasma samples collected from 313 patients with early breast cancer approximately 2 years after they had completed adjuvant chemotherapy.

Can Response-Adapted Surgery Improve Outcomes in HNSCC?

Patients who respond to neoadjuvant immunochemotherapy may be able to undergo less extensive surgery, with high rates of disease control and organ preservation.

TKI Discontinuation Feasible After ALL Treatment

In patients with first- or second-line Philadelphia-positive B-cell acute lymphoblastic leukemia, favorable outcomes are observed with discontinuation of ponatinib.

SBRT Plus Atezolizumab Shows No Benefit in Inoperable NSCLC

For patients with early-stage, inoperable lung cancer, adding atezolizumab to standard radiotherapy boosts toxicity, not survival.

Todays Updates

UK Lawmakers Reject Bid to Legalise Assisted Dying

British lawmakers rejected on Friday a proposal to legalise assisted dying for terminally ill people, dealing a major setback to campaigners and bringing the latest effort...

Liberalized Cannabis Policies May Increase Substance Use

In a global review, legalization was associated with increased cannabis use and related emergency department visits, with potential decreases in the use of alcohol and tobacco.

Tissue-Free ctDNA Predicts Recurrence in Early Breast Cancer

Researchers analyzed plasma samples collected from 313 patients with early breast cancer approximately 2 years after they had completed adjuvant chemotherapy.

Can Response-Adapted Surgery Improve Outcomes in HNSCC?

Patients who respond to neoadjuvant immunochemotherapy may be able to undergo less extensive surgery, with high rates of disease control and organ preservation.

TKI Discontinuation Feasible After ALL Treatment

In patients with first- or second-line Philadelphia-positive B-cell acute lymphoblastic leukemia, favorable outcomes are observed with discontinuation of ponatinib.

SBRT Plus Atezolizumab Shows No Benefit in Inoperable NSCLC

For patients with early-stage, inoperable lung cancer, adding atezolizumab to standard radiotherapy boosts toxicity, not survival.

Latest News

A pilot study suggests open-face SGRT immobilization is feasible for HN radiotherapy, with shoulder reproducibility similar to conventional masks.

A case of rising PSA and widespread sclerotic bone lesions turned out to be Paget's disease, not metastasis—avoiding unnecessary ADT and bone harm.

Lutetium177-PSMA-617 is a radioligand therapy for PSMA-positive metastatic castrate resistant prostate cancer after receipt of at least 1 ARPI.

VHA Directive 1415 mandates that all VA systems implement formal, documented processes with clear roles to manage suspected cancer cases.

Drs Kenneth Saag and Nicola Dalbeth explore how crystal analysis and imaging advances can sharpen gout diagnosis and guide patient care.

Clinicians should be prepared to identify vestibular migraine, the rare Ménière disease, and persistent postural perceptual dizziness, a functional disorder.

News All Time

The Looming 100-Million Cancer Workforce Crisis

Global workforce inequities are widening the cancer survival gap. Prof David Kerr highlights the stark realities and calls for an improved training approach.

Are Smart Glasses the Future of Collaborative Surgery?

Orthopedic surgeon Amgad Nakhla is using smart glasses in theater to bring remote expertise into com-plex cases and support real-time decisions.

Thyroid: A Year in Review

Drs Kaniksha Desai and Anupam Kotwal discuss thyroid: a year in review.

Fast Five Quiz: PPF Management

What do you know about the management for progressive pulmonary fibrosis? Test your knowledge with this quick quiz.

CT Radiation Risk: Is it Time to Rethink Imaging?

Two high-impact studies link routine CT scans to significant lifetime cancer risks. Dr Maurie Markman discusses why we can no longer ignore the data.

Preview: New Thyroid Nodule Guidelines

Drs Kaniksha Desai and Victor Bernet discuss the new guidelines for thyroid nodules.

Migraine and Stroke: What's the Real Risk?

Neurologist Indu Subramanian and migraine expert Andrew Charles discuss the risk for stroke in patients with migraine.

De-Escalated Treatment for Early Breast Cancer Continues to Gain Momentum

More patients of all ages skip sentinel lymph node biopsy, get less aggressive RT or none at all

Creeping Gradients After TAVR Linked to Poor Longer-Term Outcomes

Registry tracked incidence, prognostic impact of early hemodynamic valve deterioration

Pancreatic Cancer Risk Much Higher for Certain Group, Study Suggests

Long-term follow-up of low-risk pancreatic cystic lesions may be necessary

Tile-Based Radiation Tops Standard for Resected Brain Metastases

Approach significantly improved local control, and longer survival observed in trial

Trump's Doc Says President Is in 'Excellent Health' as BMI Approaches Obesity Range

Report shows Trump has a BMI of 29.7 and was given advice on diet and physical activity

ASNR Expert Video Roundtable: Expert Video Rountable from the American Society of Neuroradiology

Breakthroughs in Gastrointestinal Cancers From ASCO 2026

Breakthroughs in pancreatic cancer, novel drug combinations, and the role of observation in colorectal cancer are among the advances in gastrointestinal cancer at ASCO 2026 selected by Dr Manish Shah.

Jun 19 2026 This Week in Cardiology

Listener feedback, more long-term data on the TAVR/SAVR question, population prevalence of valvular heart disease in the US, and a CMS proposal to expand TAVR coverage are the topics John Mandrola, MD, discusses in this week’s podcast.

Planning Pregnancy in Crohn’s: Expert Insights

Dr Laura Sahyoun discusses the challenges of pregnancy in Crohn’s disease, with clinical guidance to help optimize care.

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Real World CAR T-Cell Therapy Outcomes 'Favorable' in Relapsed/Refractory Myeloma

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EGFR Inhibitors for Lung Cancer Tied to Increased Keratitis Risk.

What Caused a Man to Develop Friable Bleeding Nodules on His Arms and Hips?

An Intimate Life of Medical Innovation and Charity.

Annual whole-body, low-dose CT aids management of smoldering multiple myeloma

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