May 15 2026 This Week in Cardiology

Published Date: 16 May 2026

Another positive digoxin trial, another classic coronary physiology study from Imperial College London (ORBITA-FIRE), news in hypertrophic cardiomyopathy, and TAVR done in the wrong patients are the topics John Mandrola, MD, discusses in this week’s podcast.

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Latest News

The Vascular Etiology of Migraine Myth

Neurologist Indu Subramanian asks migraine expert Andrew Charles how the vascular hypothesis emerged and what the imaging studies really show.

AI Saves Clinicians Time but Most Lack Training, Survey Finds

AI is saving clinicians time, but the majority of healthcare professionals say training in the technology is inadequate, ⁠inconsistent or unavailable, a global survey...

Jun 05 2026 This Week in Cardiology

Managing Localized Uveal Melanoma: New Guideline Review

Dr Teresa Amaral reviews new guidelines for localized uveal melanoma, covering enucleation, radiotherapy nuances, and the current evidence on adjuvant systemic treatment.

Mavacamten Alters SCD Risk Scores, Not Outcomes

Data show marker improvement with mavacamten in obstructive HCM, but reclassification isn’t the same as proven mortality benefit — randomized or long-term outcome studies are still needed.

Age-Specific Needs in Young Women With Breast Cancer

Drs Olivia Pagani and Ann Partridge discuss how to optimize the care plan for young patients with breast cancer, focusing on age-specific concerns such as fertility and long-term survivorship.

Todays Updates

HIV Care Coordination Program May Reduce Deaths in NYC

New York City’s revised Care Coordination Program may help reduce risks for all-cause and HIV-related deaths among people with HIV infection, including those at the highest risk for poor outcomes.

Teplizumab Approved for Pediatric Stage 3 Type 1 Diabetes

The drug was previously approved for stage 2 T1D.

One in Four Teen Girls and Young Women at Risk for PMOS

Findings suggest young females should be assessed and, if at risk, monitored.

Palopegteriparatide Benefits Sustained Beyond 3 Years

Final results from the PaTHway trial show the long-acting parathyroid hormone therapy enabled patients with hypoparathyroidism to achieve independence from high-dose calcium and vitamin D supplements.

Testosterone Prescribing Often Ignores Guidelines

Only 12% of patients prescribed testosterone underwent appropriate diagnostic testing, and overprescribing was common in a single-center US study.

Encaleret Shows Rapid Response in ADH1

The oral modulator of the calcium-sensing receptor targets the causes of ADH1, significantly improving serum and urine calcium levels.

Off-Label Rxs: Thinking Out of the Box for Skin Diseases

Off-label alternatives for FDA-approved therapies can be as effective, cheaper, and in some cases safer despite never having been submitted for regulatory approval.

Todays Updates

HIV Care Coordination Program May Reduce Deaths in NYC

New York City’s revised Care Coordination Program may help reduce risks for all-cause and HIV-related deaths among people with HIV infection, including those at the highest risk for poor outcomes.

Teplizumab Approved for Pediatric Stage 3 Type 1 Diabetes

The drug was previously approved for stage 2 T1D.

One in Four Teen Girls and Young Women at Risk for PMOS

Findings suggest young females should be assessed and, if at risk, monitored.

Palopegteriparatide Benefits Sustained Beyond 3 Years

Final results from the PaTHway trial show the long-acting parathyroid hormone therapy enabled patients with hypoparathyroidism to achieve independence from high-dose calcium and vitamin D supplements.

Testosterone Prescribing Often Ignores Guidelines

Only 12% of patients prescribed testosterone underwent appropriate diagnostic testing, and overprescribing was common in a single-center US study.

Encaleret Shows Rapid Response in ADH1

The oral modulator of the calcium-sensing receptor targets the causes of ADH1, significantly improving serum and urine calcium levels.

Off-Label Rxs: Thinking Out of the Box for Skin Diseases

Off-label alternatives for FDA-approved therapies can be as effective, cheaper, and in some cases safer despite never having been submitted for regulatory approval.

Latest News

Neurologist Indu Subramanian asks migraine expert Andrew Charles how the vascular hypothesis emerged and what the imaging studies really show.

AI is saving clinicians time, but the majority of healthcare professionals say training in the technology is inadequate, ⁠inconsistent or unavailable, a global survey...

Dr Teresa Amaral reviews new guidelines for localized uveal melanoma, covering enucleation, radiotherapy nuances, and the current evidence on adjuvant systemic treatment.

Data show marker improvement with mavacamten in obstructive HCM, but reclassification isn’t the same as proven mortality benefit — randomized or long-term outcome studies are still needed.

Drs Olivia Pagani and Ann Partridge discuss how to optimize the care plan for young patients with breast cancer, focusing on age-specific concerns such as fertility and long-term survivorship.

News All Time

Will AI Replace Physicians? Can Prior Auth Be Fixed? A Q&A With HHS's Health IT Czar

Thomas Keane talks about artificial intelligence and other challenges facing his agency

First-of-Its-Kind Device for Pancreatic Cancer Wins FDA Approval

First approved therapy for locally advanced disease in almost three decades

Stereotactic Radiation Better for Patients With Multiple Brain Metastases?

Symptom severity, interference with daily functioning were improved

Should We Do a Shoulder MRI? Food Prescriptions for Diabetes

Also in TTHealthWatch: a planetary health diet, and patient views of statin therapy

Reining in Overdiagnosis of Papillary Thyroid Cancer: Easier Said Than Done

Cutting ultrasound referrals for nonpalpable nodules could lead to decreases in incidence

Beware of Radiation Doses Among Heart Scanners, Study Says

Coronary CT angiography, poorer countries under scrutiny for larger doses

Study Questions Use of Prostate Cancer Hormone Therapy in Certain Cases

Adding hormone therapy to postoperative radiotherapy did not improve OS for most patients

Routine Mammograms That Also Flag CVD: Two Birds With One Stone?

AI-driven quantification of breast arterial calcification on imaging could ID higher-risk women

Tiny Blood Smidges in the Brain: Amount and Location Tied to Dementia

Neuroimaging findings believed to arise from distinct pathologies

Even Patients Are Shocked by the Prices Their Insurers Will Pay

And it costs all of us

Lead Suits Cut Physician Radiation Exposure for Interventional Cardiology Cases

Median exposure reduced to 0 versus lead apron during LAAO, with possible broader applicability

Deepfake X-Rays Sneak Past Radiologists and AI, Underscoring Abuse Potential

Unaware they were looking at phony images, a majority of radiologists judged fakes as real

Ultrasound Treatment for Prostate Cancer Has Early Advantage Versus Prostatectomy

Better continence, erectile function, but data on oncologic outcomes still 2 years away

PSMA-PET Cuts Need for Biopsy in Suspected Prostate Cancer

But does it cost too much?

AI Strategy Could Eliminate Radiologist Review of Low-Risk Mammograms

Approach cut workload by 64% and increased cancer detection rate versus standard strategy

Low Breast Cancer Recurrence Rate With Radiotherapy Tailored to Nodal Response

Locoregional recurrence rate of 2.9% overall with no variation across node-defined risk groups

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AI Breath Test IDs Cancers; More Grief for Prior Auth; Imatinib Discoverer Resigns

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NEET SS Counseling 2023: MCC provides information on DNB SS Medical Oncology seats available at ESIC Medical College and Hospital Faridabad.

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