US FDA Clarifies Policies on Compounding Of GLP-1 Medicines

Published Date: 03 Apr 2026

The U.S. Food and Drug Administration on Wednesday clarified its policies on compounded versions of ⁠popular GLP-1 drugs, signaling tighter limits on their production as...

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Semaglutide and tirzepatide use is rising among patients with rheumatic and musculoskeletal diseases and is linked to meaningful 1-year weight loss, especially in tirzepatide users.

The Fracture Risk Assessment Tool predictions suggest patients who don’t meet guideline criteria for parathyroidectomy may nevertheless benefit from the surgery.

Specific serum acylcarnitine levels are linked to faster kidney function decline in type 2 diabetes and can help improve the prediction of patients at highest risk for rapid decline.

Modeling finds marked early weight loss with tirzepatide that later plateaus as appetite returns and energy expenditure decreases, and discontinuation of the drug is linked to partial weight regain.

Emerging evidence suggests some sugar substitutes may affect metabolism, gut microbiome, and cardiovascular health more than previously recognized.

Weight bias, stigma, and discrimination are linked to poorer mental health and weight outcomes after bariatric surgery, although the long-term physical effects remain understudied.

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