Increasing GLP-1 Use Raises Muscle Loss Concerns

Published Date: 25 Jul 2026

Incretin mimetic therapy for obesity may reduce muscle mass and bone mineral density, but its effects on physical function and the risk for fractures in older adults remain uncertain.

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In patients with obesity and knee osteoarthritis eligible for knee arthroplasty, an intensive dietary weight-loss program is clinically inferior to surgery for patient-reported pain and function.

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An increase in dietary spermidine intake over 1 year is associated with improvements in hepatic function and cardiometabolic health in older adults with overweight or obesity and metabolic syndrome.

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In patients with obesity and knee osteoarthritis eligible for knee arthroplasty, an intensive dietary weight-loss program is clinically inferior to surgery for patient-reported pain and function.

An increase in dietary spermidine intake over 1 year is associated with improvements in hepatic function and cardiometabolic health in older adults with overweight or obesity and metabolic syndrome.

Ultrasound imaging reveals structural changes in the vagus nerve of patients with Parkinson's disease in a meta-analysis.

Using both SGLT2 inhibitors and GLP-1 receptor agonists is no more effective than using either drug alone in patients with type 2 diabetes, a new meta-analysis suggests.

A mindfulness-based eating intervention improved anxiety, depression, and eating behaviors in adults with obesity and generalized anxiety disorder.

Common laboratory tests can mislead when interpreted without clinical context, highlighting why appropriate test selection matters as much as the results themselves.

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Alcohol and Marijuana Use in Type 1 Diabetes: What to Know

People with type 1 diabetes are just as likely to use substances as the rest of the population, so they need to be aware of the risks and how to mitigate them.

Semaglutide Tied to Lower Risk for Adult-Onset Seizure

In adults with type 2 diabetes, semaglutide initiation was associated with roughly half the risk for adult-onset seizure compared with other glucose-lowering medications — a protective effect that appeared independent of blood sugar or weight control.

Once-Daily Prednisolone Shows Promise for Hypoadrenalism

In a small study, once-daily prednisolone outperformed hydrocortisone for bone and cardiometabolic outcomes in patients with adrenal insufficiency.

Kidney Disease Hits Early, Hard in Kids With Spina Bifida

A population-based study finds that children with spina bifida are more likely than their peers in the general population to develop chronic kidney disease and ESRD — and to do so at younger ages.

Visceral Belly Fat Can Make You Age Faster, Experts Warn

Higher visceral fat is linked to accelerated biological aging in middle-aged adults, independent of other adiposity measures and lifestyle factors.

India Approves Novo Nordisk's Obesity Drug Wegovy for Fatty Liver Disease

Danish drugmaker Novo Nordisk said on Friday that India's drug regulator has approved its ⁠obesity drug Wegovy for the treatment of metabolic dysfunction-associated...

Glucocorticoid Use in Giant Cell Arteritis Remains High

Despite efforts to reduce glucocorticoid exposure in GCA, patients diagnosed in 2022 still received high doses — and even low-dose exposure was associated with adverse outcomes.

GLP-1s May Reduce Overdose Risk, Even After Discontinuation

People with a history of alcohol, opioid, or substance overdose who are later started on GLP-1 medications have a significantly lower risk for a repeat overdose.

Does High Cortisol Shut Down GLP-1s?

Claims circulating on social media warn that high cortisol levels can block the weight-loss effects of GLP-1, but obesity medicine experts say there is no evidence to support the idea.

Managing Diabetes and HIV Together: What to Know

As people with HIV live longer, diabetes is becoming an increasingly important contributor to morbidity and mortality, requiring specialized management approaches.
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