Studies have revealed limitations in evaluating gene editing techniques in human embryos.

Published Date: 10 Mar 2023

Most studies used to examine small amounts of DNA in early human embryos do not involve gene therapy. As a result...

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FDA approves Tezspire for chronic rhinosinusitis with nasal polyps

The U.S. Food and Drug Administration approved Tezspire (tezepelumab-ekko; Amgen) for the add-on maintenance treatment of inadequately controlled chronic rhinosinusitis with nasal polyps (CRSwNP) in adult and pediatric patients ...

In-surgery radiation cuts pancreatic cancer return

Using targeted radiation during surgery—referred to as intraoperative radiation—to eliminate pancreatic cancer cells that have spread to areas around the pancreas, investigators at Johns Hopkins have been able to reduce ...

Clinical trial presents promising DNA-encoded therapy for long-lasting protection against COVID-19

A new way to deliver protective antibodies against COVID-19 was tested in a Phase I clinical trial. Instead of injecting pre-made antibodies into patients, this approach encouraged the body to produce its own antibodies to ...

AI models help pinpoint key neoantigens for personalized skin cancer vaccines

In a new study, University of Arizona researchers created a model for cutaneous squamous cell carcinoma, a type of skin cancer, and identified two mutated tumor proteins, or neoantigens, that contain features of good candidates ...

Custom-designed protein receptors help T cells target solid tumors more effectively

Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, especially those equipped with chimeric antigen receptors (CAR-T cells), have revolutionized cancer ...

Potential cancer outcome differences among psoriasis biologics found

Copenhagen University Hospital–Herlev and Gentofte led a nationwide registry study that the authors claim shows a "pattern suggesting" a lower five-year risk of any first cancer (excluding non-melanoma skin cancer) with ...

Todays Updates

Radiation therapy for patients with breast cancer

Radiation therapy is a common component of breast cancer treatment for patients. The high-powered beams of intense energy kill cancer cells and reduce the risk of the cancer recurring.

Todays Updates

Radiation therapy for patients with breast cancer

Radiation therapy is a common component of breast cancer treatment for patients. The high-powered beams of intense energy kill cancer cells and reduce the risk of the cancer recurring.

Latest News

The U.S. Food and Drug Administration approved Tezspire (tezepelumab-ekko; Amgen) for the add-on maintenance treatment of inadequately controlled chronic rhinosinusitis with nasal polyps (CRSwNP) in adult and pediatric patients ...

Using targeted radiation during surgery—referred to as intraoperative radiation—to eliminate pancreatic cancer cells that have spread to areas around the pancreas, investigators at Johns Hopkins have been able to reduce ...

A new way to deliver protective antibodies against COVID-19 was tested in a Phase I clinical trial. Instead of injecting pre-made antibodies into patients, this approach encouraged the body to produce its own antibodies to ...

In a new study, University of Arizona researchers created a model for cutaneous squamous cell carcinoma, a type of skin cancer, and identified two mutated tumor proteins, or neoantigens, that contain features of good candidates ...

Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, especially those equipped with chimeric antigen receptors (CAR-T cells), have revolutionized cancer ...

Copenhagen University Hospital–Herlev and Gentofte led a nationwide registry study that the authors claim shows a "pattern suggesting" a lower five-year risk of any first cancer (excluding non-melanoma skin cancer) with ...

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Potential antibody therapy restricts the growth of aggressive and treatment-resistant breast cancers

A new potential antibody therapy strategy which restricts the growth of treatment-resistant breast cancers has been developed by scientists.

A less invasive, more effective method to analyze immunotherapy efficacy

Immunotherapy has been one of the most promising advancements in cancer treatment. However, consistency in immunotherapy treatment effectiveness remains a formidable challenge. Now, Cancer Center at Illinois member Kun Wang, ...

Scientists develop one-product-fits-all immunotherapy for breast cancer

Triple-negative breast cancer is one of the most aggressive cancers. The name tells the story: It lacks the three main targets that make other types of breast cancers more treatable with powerful therapies.

New targeted therapy shows promise for patients with advanced bladder cancer

FX-909, a first-in-class investigational oral small molecule inhibitor of peroxisome proliferator-activated receptor gamma (PPARG), showed early signs of clinical benefit in patients with advanced urothelial carcinoma, according ...

Investigational antibody-drug conjugate shows clinical benefit against previously treated small cell lung cancer

Zocilurtatug pelitecan (zoci), also known as ZL-1310, an investigational antibody-drug conjugate (ADC) that targets the protein DLL3, demonstrated both safety and capacity to induce anticancer responses in patients with extensive-stage ...

Zenocutuzumab shows clinical benefit in rare bile duct cancer

Zenocutuzumab (Bizengri), a bispecific antibody that targets human epidermal growth factor receptor 2 (HER2) and HER3, led to responses in more than a third of patients with neuregulin 1 (NRG1)-positive cholangiocarcinoma, ...

Existing drugs for tissue scarring could help avert melanoma relapses

Cellular changes that appear during melanoma and lead to treatment resistance can be reversed with drugs—potentially opening the door to new or more effective treatments for the deadly disease, according to new Cornell ...

New genomic test could spare some people with melanoma from lymph node biopsy surgery

A genomic test co-developed by Mayo Clinic and SkylineDx can identify whether people with melanoma are at low or high risk for cancer in their lymph nodes—a finding that could guide treatment decisions and help many people ...

Immune cell pockets found in lymphoma tumors offer new targets for personalized therapies

By analyzing the tumor environment of diffuse large B-cell lymphoma (DLBCL), researchers from The University of Texas MD Anderson Cancer Center have identified seven distinct cellular microenvironments, providing a framework ...

Elironrasib may overcome resistance to prior KRAS G12C inhibition in non-small cell lung cancer

Elironrasib led to meaningful and durable responses in patients with metastatic KRAS G12C-mutated non-small cell lung cancer (NSCLC), including after prior treatment with KRAS G12C inhibitors and in the presence of features ...

Mosquito saliva may hold clues to fighting chikungunya inflammation

Scientists from the A*STAR Infectious Diseases Labs (A*STAR IDL) have uncovered a surprising mechanism showing how mosquito saliva can alter the human body's immune response during chikungunya virus (CHIKV) infection, contributing ...

Decoding the T cell burst: Signature genes predict T cell expansion in cancer immunotherapy

The ability of immune cells—particularly CD8+ T cells—to launch a rapid burst of proliferation inside tumors is key to the success of modern day cancer immunotherapies. However, the factors and mechanisms that drive this ...

Research targets treatment resistance in neuroendocrine tumors

A novel combination therapy pairing a DNA-synthesis inhibitor with a targeted radiopharmaceutical may improve outcomes for patients with advanced neuroendocrine tumors, according to new clinical trial data presented at the ...

Triplet combinations of immunotherapy and targeted treatments as first-line therapy for advanced renal cell carcinoma

KEYMAKER-U03 is an international, multicenter, open-label, Phase I/II umbrella trial evaluating experimental combinations of pembrolizumab-based immunotherapy and targeted treatments for advanced clear cell renal cell carcinoma ...

Less than half of schoolkids at risk of food anaphylaxis in England prescribed adrenaline 'antidote'

Less than half of schoolchildren in England who are at risk of a serious and potentially life-threatening allergic reaction (anaphylaxis) to food were prescribed the antidote—an adrenaline [epinephrine] autoinjector, or ...

Recurrence-free survival longer with nivolumab than ipilimumab in melanoma: Study

For patients with resected stage IIIB-C or stage IV melanoma, recurrence-free survival is longer with nivolumab than ipilimumab, according to a study published online Oct. 18 in the New England Journal of Medicine to coincide ...

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