Can CRISPR Make CAR T Safer and More Scalable?

Published Date: 10 Jul 2026

Combining CRISPR/Cas9 with CAR T aims to let patients’ T cells be reprogrammed in vivo, potentially lowering cost and expanding use to solid tumors and autoimmune disease.

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July 24, 2026 This Week in Cardiology Podcast

The first oral PCSK9 inhibitor, another study finding safe MRI scanning in patients with nonconditional CIEDs, the PFA-SHAM trial, and the curious case of orthopedic injuries in cardiology are the topics John Mandrola, MD, discusses in this week’s podcast.

Abdominal Binders Reduce Colonoscopy Time and Pain

A compression device worn around the abdomen during colonoscopy shortens procedure time and reduces discomfort.

No Catheter After Stone Surgery May Reduce Urinary Symptoms

Catheter placement after ureteroscopic lithotripsy appears to be safe and is linked to a lower incidence of pain and urinary urgency 1 day after surgery.

Acute Ischemic Stroke State of the Art

Neurologist Christoph Diener summarizes what randomized studies in the last 4-5 years have taught us about the management of acute ischemic stroke.

Tests Show Moderate Predictive Value for Milk, Egg Allergy

Skin prick tests and specific IgE levels are moderately useful for predicting oral food challenge outcomes in patients with cow’s milk or hen’s egg allergy.

Should IVF Add-On Treatments Continue? Review Raises Doubts

Review finds limited evidence supporting most IVF add-ons, reinforcing calls for stronger trials and transparent counseling before routine use.

Todays Updates

Palliative Care Remains Uncommon in Young Adults With Cancer

Concurrent palliative care use among young adults with advanced cancer is less than 20%, with substantial variation across cancer types.

Todays Updates

Palliative Care Remains Uncommon in Young Adults With Cancer

Concurrent palliative care use among young adults with advanced cancer is less than 20%, with substantial variation across cancer types.

Latest News

The first oral PCSK9 inhibitor, another study finding safe MRI scanning in patients with nonconditional CIEDs, the PFA-SHAM trial, and the curious case of orthopedic injuries in cardiology are the topics John Mandrola, MD, discusses in this week’s podcast.

A compression device worn around the abdomen during colonoscopy shortens procedure time and reduces discomfort.

Catheter placement after ureteroscopic lithotripsy appears to be safe and is linked to a lower incidence of pain and urinary urgency 1 day after surgery.

Neurologist Christoph Diener summarizes what randomized studies in the last 4-5 years have taught us about the management of acute ischemic stroke.

Skin prick tests and specific IgE levels are moderately useful for predicting oral food challenge outcomes in patients with cow’s milk or hen’s egg allergy.

Review finds limited evidence supporting most IVF add-ons, reinforcing calls for stronger trials and transparent counseling before routine use.

News All Time

Persistent Airflow Limitation Ups Asthma Exacerbation Risk

Patients with asthma who have persistent airflow limitation face a nearly twofold higher risk for severe exacerbations and show distinct patterns of lung function decline.

Deep Dive: Why You No Longer Need to Test for Vitamin D

The Endocrine Society scrapped its vitamin D sufficiency threshold in 2024 and told doctors to stop routine testing. The lab order hasn't caught up to the guidelines.

S1 Episode 3: Diagnosis and Management of Complicated UTIs

Drs Anne Lenore Ackerman and Barbara W. Trautner discuss recent changes to the guidelines for the diagnosis and management of complicated UTIs.

US Quarantined Citizens At New York Military Base After Return From Congo, Sources Say

U.S. health officials quarantined 14 American citizens at a New York military base for four days after a recent return from the Democratic Republic of Congo, where an Ebola...

African Ancestry Tied to Increased Asthma Risk in Children

Among Black children, percent African ancestry is associated with an increased risk for asthma and allergen-specific sensitization.

Celldex to Stop Skin Disease Study After Trial Setback

Celldex Therapeutics said on Tuesday it would discontinue the development of its experimental drug for a ⁠skin disease after it failed to meet the main goal and key...

GLP-1 Drugs: Is Ozempic Face Changing Aesthetic Care?

Rapid weight loss with GLP-1 drugs is changing aesthetic practice, as surgeons address facial volume loss, excess skin, and new perioperative considerations.

Gradual Belimumab Dose Spacing Appears Feasible in Lupus

Gradually spacing belimumab doses appears feasible in patients with prolonged remission from systemic lupus erythematosus, without any disease flares over a follow-up period of 21 months.

Europe Wants Drug Security, but It Won’t Come Cheap

A new law and EU-wide vulnerability checks aim to end chronic medicine shortages. But reshoring production could raise prices — and reshape who gets treated.

World Cup Injuries Test Sports Medicine

World Cup injuries can end careers in an instant, forcing physicians to balance elite performance demands with the long road to a safe return.

JAK Inhibitors Linked to Higher Cancer Risk Across IMIDs

JAK inhibitors are associated with a higher risk for malignancy than TNF inhibitors across immune-mediated inflammatory diseases, according to a meta-analysis.

Allergy to NSAIDs Confirmed in Only About 3 in 10 Children

Most children suspected of having an allergy to NSAIDs are not truly allergic to them, and in some, a food allergy triggered by the drug may be the real reason, warranting targeted workup.

Gaza Daily Hunt for Water Lays Bare Worsening Health Crisis

Health authorities warn that Gaza is facing an unprecedented collapse of its water and sanitation systems, with consequences that could last decades.

JAK Inhibitor Timing Affects Zoster Vaccine Response in RA

Immediate initiation of JAK inhibitor therapy after recombinant zoster vaccination is linked to lower early immune responses than delayed initiation in patients with rheumatoid arthritis.

Cyclosporiasis: 3 Things to Know About Diagnosis, Management

Awareness, early recognition, and appropriate testing are key.

Temocillin: Old Antibiotic Finds a New Role

Temocillin is non-inferior to carbapenems for resistant Enterobacterales bacteraemia, offering a safe, carbapenem-sparing treatment option for patients with the infection.

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