10 Medical Breakthroughs Transforming Clinical Care

Published Date: 27 May 2026

CRISPR cures for sickle cell disease, gene therapy for hemophilia A, and expanding CAR T cell uses point to a new era of potentially curative, personalized treatments.

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Highlights in Prostate Cancer From AUA 2026

Extent of lymph node dissection, defining high-risk criteria, oral androgen deprivation therapy (ADT), and darolutamide plus ADT are among the highlights for prostate cancer management from AUA 2026.

Frozen Testicular Tissue Yields Sperm After 15 Years

A Belgian team has reported sperm production after transplanting testicular tissue frozen for more than 15 years, a potential breakthrough for fertility preservation in boys.

One Doctor’s Mission to Spread AI Literacy in Medicine

A medical oncologist seeks to use his computer science knowledge to make AI understandable to the medical community.

ASCO 2026: GI Oncology Shifts to Biomarker-Driven Care

Dr Emil Lou breaks down practice-changing GI oncology data from ASCO 2026, including transformative survival updates in pancreatic and upper GI cancers.

A Child With a Nontender, Nonbleeding Papule on Her Thigh

A 14-month-old female with a history of atopy presented with an 8-month history of a persistent, non-tender, non-bleeding cutaneous papule with an erythematous rim on the left thigh.

Is Alcohol Part of a Healthy Lifestyle?

Cardiologist Chris Labos takes a look at the French paradox and the J-shaped curve — which tout moderate alcohol as healthy — and asks is the amount of alcohol you should drink really zero?

Todays Updates

HIV Care Coordination Program May Reduce Deaths in NYC

New York City’s revised Care Coordination Program may help reduce risks for all-cause and HIV-related deaths among people with HIV infection, including those at the highest risk for poor outcomes.

Teplizumab Approved for Pediatric Stage 3 Type 1 Diabetes

The drug was previously approved for stage 2 T1D.

One in Four Teen Girls and Young Women at Risk for PMOS

Findings suggest young females should be assessed and, if at risk, monitored.

Palopegteriparatide Benefits Sustained Beyond 3 Years

Final results from the PaTHway trial show the long-acting parathyroid hormone therapy enabled patients with hypoparathyroidism to achieve independence from high-dose calcium and vitamin D supplements.

Testosterone Prescribing Often Ignores Guidelines

Only 12% of patients prescribed testosterone underwent appropriate diagnostic testing, and overprescribing was common in a single-center US study.

Encaleret Shows Rapid Response in ADH1

The oral modulator of the calcium-sensing receptor targets the causes of ADH1, significantly improving serum and urine calcium levels.

Off-Label Rxs: Thinking Out of the Box for Skin Diseases

Off-label alternatives for FDA-approved therapies can be as effective, cheaper, and in some cases safer despite never having been submitted for regulatory approval.

Todays Updates

HIV Care Coordination Program May Reduce Deaths in NYC

New York City’s revised Care Coordination Program may help reduce risks for all-cause and HIV-related deaths among people with HIV infection, including those at the highest risk for poor outcomes.

Teplizumab Approved for Pediatric Stage 3 Type 1 Diabetes

The drug was previously approved for stage 2 T1D.

One in Four Teen Girls and Young Women at Risk for PMOS

Findings suggest young females should be assessed and, if at risk, monitored.

Palopegteriparatide Benefits Sustained Beyond 3 Years

Final results from the PaTHway trial show the long-acting parathyroid hormone therapy enabled patients with hypoparathyroidism to achieve independence from high-dose calcium and vitamin D supplements.

Testosterone Prescribing Often Ignores Guidelines

Only 12% of patients prescribed testosterone underwent appropriate diagnostic testing, and overprescribing was common in a single-center US study.

Encaleret Shows Rapid Response in ADH1

The oral modulator of the calcium-sensing receptor targets the causes of ADH1, significantly improving serum and urine calcium levels.

Off-Label Rxs: Thinking Out of the Box for Skin Diseases

Off-label alternatives for FDA-approved therapies can be as effective, cheaper, and in some cases safer despite never having been submitted for regulatory approval.

Latest News

Extent of lymph node dissection, defining high-risk criteria, oral androgen deprivation therapy (ADT), and darolutamide plus ADT are among the highlights for prostate cancer management from AUA 2026.

A Belgian team has reported sperm production after transplanting testicular tissue frozen for more than 15 years, a potential breakthrough for fertility preservation in boys.

A medical oncologist seeks to use his computer science knowledge to make AI understandable to the medical community.

Dr Emil Lou breaks down practice-changing GI oncology data from ASCO 2026, including transformative survival updates in pancreatic and upper GI cancers.

A 14-month-old female with a history of atopy presented with an 8-month history of a persistent, non-tender, non-bleeding cutaneous papule with an erythematous rim on the left thigh.

Cardiologist Chris Labos takes a look at the French paradox and the J-shaped curve — which tout moderate alcohol as healthy — and asks is the amount of alcohol you should drink really zero?

News All Time

Lipid Guidelines: Four Major Concerns

Too many Class I recommendations lacking supporting data from randomized trials and intellectual conflicts of interest are among John Mandrola’s complaints about the ACC/AHA guidelines on dyslipidemia.

Canadian EHR Interoperability Weak, Uneven, Harming Patients

Most Canadian physicians use electronic health records, but a lack of connectivity means that patient health information remains siloed across different software programs.

Angiolipoleiomyoma Masquerading as Leiomyoma in a Woman

A 45-year-old woman with a 2-year vaginal foreign body sensation and constipation has a large posterior vaginal wall mass; a biopsy suggests leiomyoma, but excision reveals angiolipoleiomyoma.

Adding Lanes to the Healthcare Highway

Patients can now call, message, upload photos, complete e-visits, see primary care, go to urgent care, or request specialty care directly. And yet the backlog keeps growing. So does the inbox.

Beyond CAR-T: The Rising Potential of Natural Killer Cells

Prof David Kerr explores gene-edited NK cells and allogeneic banks as a potent, ‘off-the-shelf’ alternative to autologous CAR-T infusions.

‘Too Good to Be True?’ GLP-1s and Breast Cancer Survival

Dr F. Perry Wilson breaks down study findings suggesting a link between GLP-1 drugs and improved outcomes among patients with breast cancer and obesity.

Upper GI Disorders: New Evidence May Refine Practice

Dr David Johnson summarizes pivotal DDW 2026 studies, spotlighting emerging evidence across upper GI disorders — from Barrett’s esophagus surveillance to pancreatitis management.

Testosterone Is Back; Have We Learned From Our Mistakes?

A new push to prescribe testosterone replacement therapy led this cardiologist to review the cardiovascular risk data.

The Pitt Season 2: EM Docs Tackle Tough Diagnoses (Part 3)

Drs Robert Glatter and Amy Faith Ho continue their review of The Pitt season 2, tackling retinal artery occlusion, phytophotodermatitis, and ovarian torsion. They unpack clinical accuracy, informed consent, and bias in emergency care.

Conference MDAngle: AUA 2026 Metastatic Prostate Cancer

Insights from AUA 2026, including anticipated presentations, key takeaways, and how new research in metastatic prostate cancer will affect patient care.

AUA 2026: Previewing Metastatic Prostate Cancer Updates

Dr Hannah McManus looks ahead to the release of new data from phase 3 clinical trials that will inform multidisciplinary management.

Updates in Ovarian Cancer From SGO 2026

Landmark survival gains in ROSELLA and KEYNOTE-B96 in platinum-resistant disease plus pivotal data in low-grade serous ovarian cancer are highlights from SGO 2026, reported by Dr Amelia Jernigan.

A Primary Care Primer on Alzheimer’s Blood Tests

Alzheimer’s management may slowly be making its way to primary care, so The Curbsiders unpack the latest on blood-based biomarkers and antiamyloid therapies.

S3 Episode 3: Endometrial Cancer: Research, Early Detection, and Treatment

Drs Ursula Matulonis and Jessica St. Laurent discuss endometrial cancer research, funding, early detection, and treatment, including the impact of GLP-1 receptor agonists.

MASH Screening Made Simple: A 4-Step Guide

MASH is incredibly common, but easily missed. Dr Neil Skolnik breaks down the new AGA clinical pathway to help PCPs confidently screen and treat patients.

Differential Diagnosis of Suspected Pulmonary Fibrosis and Efficacy of Approved Therapies

Experts review the differential diagnosis of suspected IPF, highlighting how a multidisciplinary approach confirmed the diagnosis and informed selection of optimal antifibrotic therapy.

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