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Published Date: 13 Mar 2023

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Mitochondria and lysosomes reprogram immune cells that dampen inflammation

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system. St. Jude Children's Research Hospital scientists recently uncovered how mitochondria, ...

Researchers develop innovative vascularized tumor model to advance cancer immunotherapy

A research team led by the Faculty of Dentistry at The University of Hong Kong (HKU) has developed a novel vascularized tumor model using a non-surgical injectable hydrogel system. This innovative approach provides a powerful ...

Immune-hot brain tumor subtype that defies survival expectations discovered

A research team has discovered a previously overlooked subtype of brain tumor termed IME IDH-mutant astrocytoma. Contrary to typical medical expectations, this subtype exhibits strong immune activity, classified as "immune‑hot," ...

Decades-old asthma theory challenged: Newly discovered molecules may be real drivers of disease

For decades, scientists have thought they understood the biochemical machinery that causes asthma—inflammation in the lungs that constricts airways and makes it hard to breathe.

Potential antibody therapy restricts the growth of aggressive and treatment-resistant breast cancers

A new potential antibody therapy strategy which restricts the growth of treatment-resistant breast cancers has been developed by scientists.

Existing drugs for tissue scarring could help avert melanoma relapses

Cellular changes that appear during melanoma and lead to treatment resistance can be reversed with drugs—potentially opening the door to new or more effective treatments for the deadly disease, according to new Cornell ...

Todays Updates

'Sleep ALL night' program helps children with leukemia sleep better during treatment

Disrupted sleep is a common, often overlooked problem for pediatric patients being treated for acute lymphoblastic leukemia (ALL). To address this issue, researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders ...

Todays Updates

'Sleep ALL night' program helps children with leukemia sleep better during treatment

Disrupted sleep is a common, often overlooked problem for pediatric patients being treated for acute lymphoblastic leukemia (ALL). To address this issue, researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders ...

Latest News

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system. St. Jude Children's Research Hospital scientists recently uncovered how mitochondria, ...

A research team led by the Faculty of Dentistry at The University of Hong Kong (HKU) has developed a novel vascularized tumor model using a non-surgical injectable hydrogel system. This innovative approach provides a powerful ...

A research team has discovered a previously overlooked subtype of brain tumor termed IME IDH-mutant astrocytoma. Contrary to typical medical expectations, this subtype exhibits strong immune activity, classified as "immune‑hot," ...

For decades, scientists have thought they understood the biochemical machinery that causes asthma—inflammation in the lungs that constricts airways and makes it hard to breathe.

A new potential antibody therapy strategy which restricts the growth of treatment-resistant breast cancers has been developed by scientists.

Cellular changes that appear during melanoma and lead to treatment resistance can be reversed with drugs—potentially opening the door to new or more effective treatments for the deadly disease, according to new Cornell ...

News All Time

Research targets treatment resistance in neuroendocrine tumors

A novel combination therapy pairing a DNA-synthesis inhibitor with a targeted radiopharmaceutical may improve outcomes for patients with advanced neuroendocrine tumors, according to new clinical trial data presented at the ...

Triplet combinations of immunotherapy and targeted treatments as first-line therapy for advanced renal cell carcinoma

KEYMAKER-U03 is an international, multicenter, open-label, Phase I/II umbrella trial evaluating experimental combinations of pembrolizumab-based immunotherapy and targeted treatments for advanced clear cell renal cell carcinoma ...

Recurrence-free survival longer with nivolumab than ipilimumab in melanoma: Study

For patients with resected stage IIIB-C or stage IV melanoma, recurrence-free survival is longer with nivolumab than ipilimumab, according to a study published online Oct. 18 in the New England Journal of Medicine to coincide ...

Less than half of schoolkids at risk of food anaphylaxis in England prescribed adrenaline 'antidote'

Less than half of schoolchildren in England who are at risk of a serious and potentially life-threatening allergic reaction (anaphylaxis) to food were prescribed the antidote—an adrenaline [epinephrine] autoinjector, or ...

Immune-altering drug suppresses tumor-protecting cells and enhances stomach cancer treatment

Working with an international team of collaborators, scientists at Columbia University have found a way to shift the balance of a type of white blood cell inside a stomach tumor, causing the immune system to recognize and ...

ADC improves outcomes in advanced triple-negative breast cancer patients ineligible for immune checkpoint inhibitors

Patients with an aggressive form of breast cancer who are not candidates for immune checkpoint inhibitor therapy showed significantly improved progression-free survival when treated with the antibody drug conjugate sacituzumab ...

How multiple sclerosis harms a brain long before symptoms appear

By the time patients start seeking care for multiple sclerosis (MS), the disease has already been damaging their brains for years. But until recently, scientists didn't understand which brain cells were being targeted or ...

New generation of antibody-drug conjugates shows promise in early-stage HER2-positive breast cancer

In a landmark moment at the ESMO Congress 2025, pivotal studies have unveiled compelling evidence that a new class of anti-cancer agents—antibody-drug conjugates (ADCs)—can dramatically improve outcomes for patients with ...

Blood test guides post-surgical immunotherapy for muscle-invasive bladder cancer

Patients with muscle-invasive bladder cancer who test positive for circulating tumor (ct)DNA after surgery to remove the cancer benefit from immunotherapy with atezolizumab compared to placebo whereas ctDNA-negative patients ...

Scientists discover how cells protect the skin from inflammatory disease—paving the way for new treatments

Researchers at VIB and Ghent University have uncovered a key mechanism that protects the skin from harmful inflammation. The findings, published in Immunity, could open new avenues for treating chronic skin diseases and other ...

Combination of immunotherapy and targeted therapy boosts colorectal cancer survival, clinical trial finds

A new study led by UCLA investigators found that combining zanzalintinib, a targeted therapy drug, and atezolizumab, an immune checkpoint inhibitor, helped patients with metastatic colorectal cancer, the second most common ...

Targeted immunotherapy combination offers hope to older adults with leukemia

Researchers from the Alliance for Clinical Trials in Oncology have found that two targeted immunotherapy drugs lead to high remission rates and long survival with reasonable side effects for older patients with a tough-to-treat ...

VT3989 continues to show promising early results in patients with advanced mesothelioma

The first-in-class YAP-TEAD inhibitor VT3989 continued to be well tolerated and demonstrated notable initial antitumor activity, particularly in patients with refractory mesothelioma, according to results from a trial led ...

Supercharging immune cells to fight drug resistant bowel cancer

Scientists at University College London have engineered a rare type of immune cell to kill slow-growing bowel cancer cells that are resistant to current therapies, a breakthrough that could lead to new treatments in the future.

'Craters' on surface of melanoma cells mark tumor-killing hotspots, study reveals

New research published in Cell finds the existence of craters on the surface of melanoma cells that serve as immune hubs, becoming major sites for tumor killing. These craters could serve as good markers for immunotherapy ...

How bacteria in tumors drive treatment resistance in cancer

Researchers from The University of Texas MD Anderson Cancer Center have discovered a previously unknown mechanism that explains how bacteria can drive treatment resistance in patients with oral and colorectal cancer. The ...

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