CGRP Drugs for Migraine: Outstanding Clinical Questions

Published Date: 24 Feb 2026

As CGRP-targeted therapies move into wider use, new data are beginning to clarify their role in special populations, the value of switching agents when one fails, and their long-term vascular safety.

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Pregnant individuals in the emergency department have low rates of sexually transmitted infection screening and limited access to prenatal care, a study finds.

Individuals hospitalized for sickle cell disease acute pain episodes were randomly assigned to receive either intravenous or saline placebo.

Brazilian researchers are developing vaccine candidates tailored to the country’s predominantly P vivax malaria burden, with one approach moving toward human testing.

Many clinicians recognize irritable bowel syndrome by its Rome criteria, but still order unnecessary tests, highlighting gaps in the application of positive diagnostic strategies.

Vomiting, poor feeding, and failure to thrive may signal more than common infant illness. BfR urges clinicians to consider vitamin D overdose and hypercalcemia.

From thicker mattresses to sound-absorbing walls, geriatric emergency departments transform care for older patients.

News All Time

Physicians Working Excessive Hours More Likely to Quit

Physician working conditions often breach the European Working Time Directive, and derogations correlate with health deteriorations and intentions to leave the profession.

Pediatric Firework Injuries More Common in Teens and Boys

Firework-related upper-extremity injuries continue to disproportionately affect boys and adolescents, with burns to the hands and fingers being most common, a study finds.

Updated Guidelines Refine Solitary Plasmacytoma Diagnosis

New recommendations emphasize advanced imaging and bone marrow assessment to distinguish localized disease from occult systemic involvement and guide appropriate treatment.

How Obesity Affects Operating Room Procedures: Q&A

Surgeons and anesthesiologists need deeper understanding of patient’s background when obesity is at play.

Many Patients With B-Cell Lymphoma Miss Second-Line Care

More than 10% of patients with large B-cell lymphoma may die within a year of starting first-line treatment without ever receiving second-line therapy, a study finds.

ASGE Guideline: Endoscopic Management of Colonic Strictures

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Paediatric e-Scooter Injuries Rising Sharply, Study Finds

Nearly 500 children in England were treated for e-scooter injuries over 6 years, with fewer than 2% wearing a helmet.

Thousands of US Kids Hospitalized for Vitamin Toxicity

Thousands of children have been hospitalized after poisoning by vitamins and minerals in recent years, the majority ingested intentionally.

Irinotecan Fails to Boost Rectal Cancer Outcomes

Adding irinotecan to standard chemoradiotherapy for MRI-defined, locally advanced rectal cancer did not improve disease-free survival or pathologic complete response rates but increased toxicity, including diarrhea and neutropenia.

ED Hepatitis C Screening Reaches More Homeless Patients

People experiencing homelessness are more likely to accept nontargeted hepatitis C screening in the emergency department and have higher rates of HCV infection, a study finds.

Popular Opioids May Not Relieve Breathlessness in COPD

Low-dose fentanyl and morphine offer no relief from persistent breathlessness in severe chronic obstructive pulmonary disease (COPD), a study finds.

In-Room Tech Changing Care for Patients and Hospitalists

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Bladder Cancer Care Is Entering a New Era

From enhanced cystoscopy to antibody-drug conjugates, bladder cancer care is shifting toward more personalized diagnosis and treatment.

Meta Ordered to Pay $567 Million in New Mexico for Teen Mental Health Fund

A New Mexico state court ordered Meta on Thursday to pay $567 million into a teen mental health fund and change how its platforms function for young users after finding the...

Nearly Half of Patients With IMC Show Steroid Failure

Nearly half of patients with immune-mediated colitis show corticosteroid therapy failure, with prior steroid use, endoscopic findings, and higher symptom severity serving as predictors of failure.

Legal Drinking Ages May Spike Youth Mortality and Self-Harm

Reaching legal drinking age is linked to immediate short-term surges in alcohol-related deaths, fatal accidents, and hospital-treated suicide attempts among Finnish young adults.

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