Herpes Simplex Virus Esophagitis in an Immunocompetent Man

Published Date: 22 Jun 2026

Severe esophageal symptoms that do not respond to standard treatment may warrant endoscopic evaluation and targeted diagnostic testing.

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Molecular testing for metastatic prostate cancer with next generation sequencing (NGS) is standard for the evaluation for targetable pathogenic variants.

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PSA-Discordant Progression in Metastatic Prostate Cancer

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Tissue-Free ctDNA Predicts Recurrence in Early Breast Cancer

Researchers analyzed plasma samples collected from 313 patients with early breast cancer approximately 2 years after they had completed adjuvant chemotherapy.

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Patients who respond to neoadjuvant immunochemotherapy may be able to undergo less extensive surgery, with high rates of disease control and organ preservation.

TKI Discontinuation Feasible After ALL Treatment

In patients with first- or second-line Philadelphia-positive B-cell acute lymphoblastic leukemia, favorable outcomes are observed with discontinuation of ponatinib.

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For patients with early-stage, inoperable lung cancer, adding atezolizumab to standard radiotherapy boosts toxicity, not survival.

Todays Updates

UK Lawmakers Reject Bid to Legalise Assisted Dying

British lawmakers rejected on Friday a proposal to legalise assisted dying for terminally ill people, dealing a major setback to campaigners and bringing the latest effort...

Liberalized Cannabis Policies May Increase Substance Use

In a global review, legalization was associated with increased cannabis use and related emergency department visits, with potential decreases in the use of alcohol and tobacco.

Tissue-Free ctDNA Predicts Recurrence in Early Breast Cancer

Researchers analyzed plasma samples collected from 313 patients with early breast cancer approximately 2 years after they had completed adjuvant chemotherapy.

Can Response-Adapted Surgery Improve Outcomes in HNSCC?

Patients who respond to neoadjuvant immunochemotherapy may be able to undergo less extensive surgery, with high rates of disease control and organ preservation.

TKI Discontinuation Feasible After ALL Treatment

In patients with first- or second-line Philadelphia-positive B-cell acute lymphoblastic leukemia, favorable outcomes are observed with discontinuation of ponatinib.

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Molecular testing for metastatic prostate cancer with next generation sequencing (NGS) is standard for the evaluation for targetable pathogenic variants.

What role do diet, obesity, the microbiome, and screening play in early-onset colorectal cancer? Dr Benjamin Levy and Dr Aasma Shaukat discuss the latest evidence.

Rare squamous transformation in metastatic prostate cancer caused disease progression despite suppressed PSA, found only through re-biopsy.

No dose of alcohol is risk-free, and none protects the heart. It's time to counsel patients on drinking less rather than where the line sits.

A woman receiving ruxolitinib for polycythemia vera developed disseminated tuberculosis despite a negative IGRA, highlighting the limits of screening.

From nutrition screening to IBD monitoring, AI shows promise in pediatric gastroenterology — yet experts stress pediatric validation is essential.

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S1 Episode 4: How Early Is Early Enough to Reverse MASLD?

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ArteraAI: Current Indications in Prostate Cancer

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Teen With a Slowly Enlarging Annular Hyperkeratotic Papule

The lesion initially appeared as a small papule and gradually enlarged, with more noticeable growth in recent months. The lesion was not painful, pruritic, or bleeding.

Thyroid Surgery: Practical Strategies for Optimal Post-op Care

Drs Kaniksha Desai and Michael Yeh discuss practical aspects of postoperative thyroid surgery care.

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Rapid Genetic Screening May Protect Newborn Hearing

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Early Breast Cancer: Time to Act on Molecular Resistance?

In breast cancer, molecular resistance can precede clinical progression, but should it prompt an immediate change in treatment?

Punch Biopsy Techniques Every PCP Should Know

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Risk Assessment of Thyroid Nodules: A Practical Guide

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A PCP’s Guide to Tangential Shave Biopsy

Learn how to perform a tangential shave biopsy with confidence. This step-by-step guide walks PCPs through the essential technique for sampling skin lesions and tumors.

Four Signs You Should Biopsy a Skin Lesion, Not Freeze It

Before you freeze a skin lesion, ask yourself whether you really know what it is. Here are four signs you should biopsy instead of freeze.

BRCA Testing Shifts From Late Data to Urgent Priority

BRCA testing now guides urgent treatment decisions as well as family risk assessment, and Spanish experts highlight its implications for PARP inhibitors, oncofertility, liquid biopsy, and exercise.

Wet Age-Related Macular Degeneration Updates From ASRS 2026

Updates in wet AMD from ASRS 2026 include real-world data on anti-VEGF treatment persistence, ELARA data on aflibercept 8 mg, as well as two studies showing reduced injection burden via gene therapy.

Stop Assuming Every Thick, Yellow Nail Is Fungus

Treating toenail fungus without confirming the diagnosis is a common mistake. Here's how to confirm it, treat it, and know what to expect.

Trust Me — I'm a Podcaster

Public trust in institutions has waned but patients trust their personal doctors. Clinicians can be influencers without TikTok or a podcast writes this podcasting cardiologist.

Erythematous Infiltrated Papules and Plaques on the Forehead

A 32-year-old woman presented to the dermatology department with asymptomatic raised, reddish lesions on the right forehead of 5 months’ duration.

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