Reconstruction of mutated C9orf72 gene sheds light on abnormal protein synthesis in neurodegenerative disorders

Published Date: 06 Nov 2025

Translation factors eIF1A and eIF5B are key repressors of an abnormal protein translation process linked to neurodegenerative disorders, as reported by researchers from Science Tokyo.

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Chronic pain is a daily reality for millions of Americans, interfering with their everyday activities and quality of life. An estimated 24.3% of adults in the United States experienced chronic pain in 2023, and current treatment ...

A new study led by Yale's Jennifer Miller, Ph.D., found that medicines are not physically accessible in many of the countries where they are tested for FDA approval. The findings were published in JAMA Internal Medicine.

Animals survive in changing and unpredictable environments by not merely responding to new circumstances, but also, like humans, by forming inferences about their surroundings—for instance, squirrels understand that certain ...

Often dismissed as a minor ailment, migraine is a debilitating neurological disease affecting hundreds of thousands of New Zealanders. At the University of Otago's School of Biomedical Sciences, world-leading research by ...

Scientists think snakes and lizards could help them find new ways to prevent painful kidney stones and gout in people. And it all owes to an evolutionary trick.

The record-breaking federal government shutdown marked yet another impediment to scientific research efforts at the Wistar Institute this year.

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Scientists complete first drafts of developing mammalian brain cell atlases

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Slowed by sound: Mouse model of Parkinson's disease shows noise affects movement

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'Molecular glues' and 'bumpers' offer new hope for precision medicines

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, turning the cell's busiest ...

Astringent, sharper mind: Flavanols can trigger brain activity for memory and stress response

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Opening the door to a vaccine for multiple childhood infections

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Hundreds of animal studies on brain damage after stroke flagged for problematic images

A new study has identified over 240 scientific publications on animal models of hemorrhagic stroke that contain potentially problematic images, thereby raising concerns about the trustworthiness of the body of literature ...

Decentralized future: Expanding clinical trials by allowing people to participate from home

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In drug trials, lack of oversight of research ethics boards could put Canadian patients at risk

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Discovery of 'doorstop' for brain's electrical gates may open path to new therapies for neurodegenerative conditions

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WHO's priorities shaped by its reliance on grants from donor organizations, study suggests

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Opt-out organ donation policies may reduce organ supply

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New Hampshire man resumes dialysis after record 271 days living with a pig kidney

A New Hampshire man is resuming dialysis after living with a gene-edited pig kidney for a record 271 days, doctors said Monday. His experience is helping researchers in their quest for animal-to-human transplants.

Liver transplantation utilizing grafts donated after euthanasia is feasible, study suggests

Organ donation following medical assistance in dying (MAiD), also known as euthanasia, is a relatively new practice both in North America and worldwide. A first comparison of liver transplantation using organs donated after ...

A 'bird's eye view' of how human brains operate

A new study provides the best evidence to date that the connection patterns between various parts of the human brain can tell scientists the specialized functions of each region.

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Deciphering how the GR forms oligomers—through the binding of several subunits—opens a crucial avenue for developing more selective drugs. These new drugs could modulate this association and thus minimize serious adverse ...

Breastfeeding's impact on bone density could boost development of osteoporosis drugs

Pregnancies do not weaken a woman's skeleton. Breastfeeding, however, can reduce bone density considerably. These are findings from a research report produced at Lund University in Sweden. But breastfeeding women need not ...

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