An original stem cell study provides insight into Klinefelter syndrome.

Published Date: 05 Apr 2023

Scientists have conducted a first-of-its-kind study in a collaboration between King Abdullah University of Science and Technology (KAUST), King Abdulaziz University, Jeddah (KAU), and King Abdulaziz University Hospital, Jeddah (KAUH).

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Researchers from the German Cancer Research Center and the University of Freiburg show how certain painkillers influence the iron metabolism of liver cancer cells and can thus contribute to iron deficiency and anemia in cancer ...

For decades, scientists have known that mitochondria, which produce energy inside our cells, malfunction in Parkinson's disease. But a critical question remained: do the failing mitochondria cause Parkinson's, or do they ...

For most women, menopause occurs naturally around the age of 49. In the lead up to menopause, the quality and quantity of eggs declines over time. Then the ovaries stop releasing eggs completely.

Researchers led by St Michael's Hospital in Toronto report that ketogenic diets are associated with modest reductions in depressive symptoms in adults, while evidence for anxiety remains uncertain.

When labor begins, the uterus must coordinate rhythmic, well-timed contractions to deliver the baby safely. While hormones such as progesterone and oxytocin are key contributors to that process, scientists have long suspected ...

Shilpa Gajarawala struggled with hot flashes, night sweats, sleep problems and brain fog. But given her history of breast cancer, treating these menopausal symptoms with hormone therapy wasn't an option.

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Sleep-related disorders associated with hypertension in postmenopausal women

Postmenopausal women are especially vulnerable to hypertension, which is a major cardiovascular risk factor. Women transitioning through or past the menopause transition are also more likely to report sleep disturbances (shorter ...

Blocking gene improves metabolic health in obese mice without weight loss

Weill Cornell Medicine investigators have identified an early step in a cellular process that leads to inflammation in fat cells and may result in type 2 diabetes in people with obesity.

Experimental drug protects mitochondria and prevents kidney injury in mice

Serious damage to short-term kidney function—known as acute kidney injury, or AKI—can be fatal and also increase the risk of irreversible chronic kidney disease. It can be triggered by stressors ranging from sepsis to ...

The flexible brain: How circuit excitability and plasticity shift across the day

Our brains do not react in a fixed, mechanical way like electronic circuits. Even if we see the same scene every day on our commute to work, what we feel—and whether it leaves a lasting impression—depends on our internal ...

Estrogen's role in boosting dopamine and cognition: Experiments uncover how hormones influence learning

Researchers have long established that hormones significantly affect the brain, creating changes in emotion, energy levels, and decision-making. However, the intricacies of these processes are not well understood.

Cutting key amino acids from mouse diets triggers weight loss through heat burning

It's not pleasant to shiver from the cold, but for some, it has the appeal of making the body burn more energy as heat than when staying in a warmer environment. According to several studies, exposure to cold is a reliable ...

Routine use of metabolic drug recommended for all kidney function levels

The results of two large-scale studies demonstrate that sodium-glucose co-transporter 2 (SGLT2) inhibitors significantly reduce the risk of kidney disease progression, hospitalization, and death in people with and without ...

Urolithin A nudges aging immune cells toward a youthful profile in 28 days

An international research team focused on aging reports that urolithin A at 1,000 mg per day shifted human immune profiles toward a more naive-like, less exhausted CD8+ state and increased fatty acid oxidation capacity, with ...

Why morning exercise feels so hard

Your alarm goes off. Somehow you manage to get dressed, drag yourself to the gym, and start squatting.

Urinary albumin-creatinine ratio better measures risk for kidney failure

The urinary albumin-creatinine ratio (UACR) is more strongly associated with kidney failure than the urinary protein-creatinine ratio (UPCR), according to research published online Nov. 4 in the Annals of Internal Medicine.

Missing enzyme may explain impaired bone growth

Chondrocytes play a crucial role in skeletal development. Many bones, such as those in the arms and legs, are formed through endochondral ossification, in which chondrocytes assemble to create a cartilage scaffold that is ...

Q&A: Managing menopause after cancer

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Widely used pesticides may lower sperm count

Contemporary agricultural practices make it difficult to prevent consuming chemicals and potentially causing harm to the body.

New research challenges simplistic views on detransition

As access to gender-affirming care has expanded in recent years, public and clinical understandings of gender transition and detransition have remained limited and highly politicized. Anecdotal reports of detransition have ...

Triggering cell death in metastatic melanoma may pave the way for new cancer treatments

Metastatic melanoma cells that have spread to lymph nodes survive by relying on a protein called ferroptosis suppressor protein 1 (FSP1)—a surprising metabolic dependency that could open the door to a new class of cancer ...

Missing a common protein could affect how muscles respond to testosterone

Lacking a common protein may affect how muscles respond to testosterone, potentially affecting athletic performance and age-related muscle loss, according to a new study.

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