Exploring the role of T cells in Alzheimer's disease, suggests new treatment strategies

Published Date: 10 Mar 2023

Nearly two dozen clinical trials targeting the immune system are in clinical trials for Alzheimer's disease.

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Neuromuscular Changes May Persist After Ligament Surgery

Patients who undergo anterior cruciate ligament reconstruction may show persistent neuromuscular alterations during functional tasks, despite reduced joint position sense errors.

Alzheimer Pathology Linked to Timely Dementia Diagnosis

Alzheimer disease and LATE-NC pathology were associated with more timely dementia diagnoses, a study shows.

Restricting Sugar in Early Life Tied to Lower Dementia Risk

Limiting sugar during pregnancy and infancy is associated with reduced risk for dementia during adulthood, delayed disease onset, and benefits for brain health, a study shows.

Ponesimod Safe, Effective Over 13 Years in RRMS

Ponesimod is well tolerated and effective for up to 13 years in patients with relapsing-remitting multiple sclerosis, a combined analysis shows.

Antiamyloid Criteria May Exclude Many With Atypical AD

Standard cognitive screening thresholds may exclude many patients with biomarker-confirmed atypical Alzheimer’s disease despite early-stage functional impairment, new data show.

Fluctuations in Sleep Patterns Common in Schizophrenia

Variability in sleep efficiency and time in bed is increased in individuals at clinical high risk for psychosis or with schizophrenia spectrum disorders, new research shows.

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Adrenal Incidentalomas: When to Worry and What to Test

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Understanding the 'Wait Time Paradox' in Ovarian Cancer

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Adapting Approaches in the Fibromyalgia Landscape

Dr Andrea Chadwick describes how the shift from tender points to symptom-based criteria has improved fibromyalgia diagnosis, understanding, and patient-centered care.

The Expanding Use of CGM for Diabetes

Dr Anne Peters discusses the expanding use of continuous glucose monitoring in people with diabetes.

Four Signs You Should Biopsy a Skin Lesion, Not Freeze It

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EyePoint's Drug for Age-related Eye Disease Fails Late-stage Trial, Shares Tank

EyePoint said its experimental drug missed the main goal in a late-stage trial as a few patients lost vision ⁠from causes unrelated to the targeted disease, sending its...

FDA Approves Brain-imaging Agent for Alzheimer's Assessment

The FDA has approved a radioactive agent for use ⁠in brain scans to help assess patients for Alzheimer's disease.

Todays Updates

Adrenal Incidentalomas: When to Worry and What to Test

Not all adrenal incidentalomas need the same workup. The Curbsiders break down when to worry, what to test, and why MACS may be behind your patient's hard-to-control metabolic disease.

Understanding the 'Wait Time Paradox' in Ovarian Cancer

Dr Maurie Markman examines new registry data on ovarian cancer diagnostic timing, showing how disease biology can complicate the link between early detection and survival.

Adapting Approaches in the Fibromyalgia Landscape

Dr Andrea Chadwick describes how the shift from tender points to symptom-based criteria has improved fibromyalgia diagnosis, understanding, and patient-centered care.

The Expanding Use of CGM for Diabetes

Dr Anne Peters discusses the expanding use of continuous glucose monitoring in people with diabetes.

Four Signs You Should Biopsy a Skin Lesion, Not Freeze It

Before you freeze a skin lesion, ask yourself whether you really know what it is. Here are four signs you should biopsy instead of freeze.

EyePoint's Drug for Age-related Eye Disease Fails Late-stage Trial, Shares Tank

EyePoint said its experimental drug missed the main goal in a late-stage trial as a few patients lost vision ⁠from causes unrelated to the targeted disease, sending its...

FDA Approves Brain-imaging Agent for Alzheimer's Assessment

The FDA has approved a radioactive agent for use ⁠in brain scans to help assess patients for Alzheimer's disease.

Latest News

Patients who undergo anterior cruciate ligament reconstruction may show persistent neuromuscular alterations during functional tasks, despite reduced joint position sense errors.

Alzheimer disease and LATE-NC pathology were associated with more timely dementia diagnoses, a study shows.

Limiting sugar during pregnancy and infancy is associated with reduced risk for dementia during adulthood, delayed disease onset, and benefits for brain health, a study shows.

Ponesimod is well tolerated and effective for up to 13 years in patients with relapsing-remitting multiple sclerosis, a combined analysis shows.

Standard cognitive screening thresholds may exclude many patients with biomarker-confirmed atypical Alzheimer’s disease despite early-stage functional impairment, new data show.

Variability in sleep efficiency and time in bed is increased in individuals at clinical high risk for psychosis or with schizophrenia spectrum disorders, new research shows.

News All Time

Personalized Gene Therapy Promising in Rare Epilepsy

Individualized gene therapies reduce seizures and lead to developmental gains in two boys with severe, treatment-resistant SCN2A-related epilepsy.

US FDA Approves Over-the-counter Tylenol Combination Pill for Pain Relief

The U.S. Food and Drug Administration on Friday approved a nonprescription, fixed-dose ⁠pill that combines Kenvue's Tylenol with the nonsteroidal anti-inflammatory drug...

Pollution Linked to French-British Oil Firm's Congo Operations Poses Health Risks, Report Says

Human Rights Watch said on Monday pollution linked to the operations of French-British oil firm Perenco in the Democratic ⁠Republic of Congo was exposing nearby communities...

Novel Neuromodulation Restores Movement After Paralysis

An experimental neuromodulation system enables a man with complete spinal cord injury to regain hand movement, sensation, and the ability to feed himself and grasp objects.

Mechanical Restraint in Psychiatric Care Tied to VTE Risk

Mechanical restraint is linked to a higher risk for venous thromboembolism than forced sedation in inpatients with psychiatric conditions, a new study shows.

TBI History Tied to False-Negative Alzheimer’s Blood Test

FDA-approved p-tau217/amyloid-beta-42 testing missed more amyloid PET-positive cases among older adults with prior TBI, a cross-sectional cohort study shows.

p-Tau217 May Predict Cognitive Decline Years Before Symptoms

Higher plasma p-tau217 levels identified cognitively sound older adults at greater risk for future cognitive impairment up to a decade before symptom onset.

ENTF Stim Boosts Freedom From Disability Post-Stroke

Electromagnetic stimulation combined with physical and occupational therapy is linked to a higher rate of freedom from disability post-stroke than sham, a study shows.

Rituximab Noninferior to Ocrelizumab in Relapsing MS

Rituximab is noninferior to ocrelizumab in suppressing disease activity in newly diagnosed multiple sclerosis, with a similar incidence of adverse events, a new trial shows.

FDA Neurology Roundup: June 2026

A monthly snapshot of FDA activity involving therapies for the prevention and treatment of neurologic diseases.

AI Uncovers ‘Invisible’ Cortical Lesions in MS MRI Scans

AI-enhanced analysis of conventional MRI scans reveals thousands of hidden cortical lesions in multiple sclerosis, potentially opening a new window into disease progression.

Deep Brain Stimulation Tied to Lower Mortality in PD

Deep brain stimulation is linked to reduced risks for mortality and institutionalization, and lower healthcare costs in adults with Parkinson’s disease, a study shows.

Ask the IIM Experts: From Immune Mechanisms to Emerging Therapies - A Comprehensive Update on Idiopathic Inflammatory Myopathies

Ask the IIM Experts: From Immune Mechanisms to Emerging Therapies - A Comprehensive Update on Idiopathic Inflammatory Myopathies

What Is Causing This Case of Sudden Aphasia?

Clues come from a kidney injury, encephalop­athy, and drug dosing error

Neuropathy After Recreational Use of Laughing Gas

Clinicians should be aware of adverse effects of this increasingly popular drug

Alzheimer's Biomarkers Change After Tuberculosis Vaccination

BCG vaccine altered immune responses and modified amyloid-beta, study shows

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