Exploring the role of T cells in Alzheimer's disease, suggests new treatment strategies

Published Date: 10 Mar 2023

Nearly two dozen clinical trials targeting the immune system are in clinical trials for Alzheimer's disease.

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New Fall-Detection Tech Could Ease Nursing Workloads

AI-powered radar systems may alert staff before a fall happens, with early studies showing fewer falls and less strain on nursing teams.

Popular Joint Supplement Tied to Faster AD Progression

A new study links glucosamine use to faster progression from MCI to dementia and identifies glycan metabolism as a potential new therapeutic target in Alzheimer’s disease.

Huntington Therapy Faces Regulatory Roller Coaster

uniQure may seek approval in the UK first while in talks with the FDA about its request for a larger, sham-controlled trial of the one-time, invasive gene therapy AMT-130.

Simple Reflex Exam May Predict Future Dementia Risk

Multiple frontal release signs among cognitively normal older adults are associated with a higher risk for dementia and faster cognitive decline.

Beyond Amyloid: What’s in the Pipeline for Alzheimer’s?

Alzheimer’s drug development now targets tau, neuroinflammation, metabolism, and synaptic dysfunction — expanding beyond amyloid toward precision medicine and combination therapy.

Vomiting During Migraine Attacks Tied to Rapid Pain Relief

Vomiting during a migraine attack is associated with relief or freedom from pain in more than half of patients, a new study shows.

Todays Updates

Multiple Myeloma Patients Have Unequal Access to Treatment

Lack of access to innovative and effective treatments compromises survival outcomes for many patients in Europe with multiple myeloma.

e-Cigarettes and Lung Cancer: Is Harm Reduction Overstated?

A large study links the use of e-cigarettes after smoking cessation to higher lung cancer incidence and mortality than complete nicotine abstinence.

Combination Treatment May Improve Multiple Myeloma Outcomes

Post hoc analysis of the MajesTEC-3 trial shows the efficacy of the teclistamab plus daratumumab combination in hard-to-treat patients with high cytogenetic and functional risk.

Is There a Role for Stimulants in Beating Cancer Fatigue?

Guidelines on treating cancer fatigue offer little enthusiasm for methylphenidate and other stimulants. But a recent meta-analysis suggests the medications deserve a rethink.

Todays Updates

Multiple Myeloma Patients Have Unequal Access to Treatment

Lack of access to innovative and effective treatments compromises survival outcomes for many patients in Europe with multiple myeloma.

e-Cigarettes and Lung Cancer: Is Harm Reduction Overstated?

A large study links the use of e-cigarettes after smoking cessation to higher lung cancer incidence and mortality than complete nicotine abstinence.

Combination Treatment May Improve Multiple Myeloma Outcomes

Post hoc analysis of the MajesTEC-3 trial shows the efficacy of the teclistamab plus daratumumab combination in hard-to-treat patients with high cytogenetic and functional risk.

Is There a Role for Stimulants in Beating Cancer Fatigue?

Guidelines on treating cancer fatigue offer little enthusiasm for methylphenidate and other stimulants. But a recent meta-analysis suggests the medications deserve a rethink.

Latest News

AI-powered radar systems may alert staff before a fall happens, with early studies showing fewer falls and less strain on nursing teams.

A new study links glucosamine use to faster progression from MCI to dementia and identifies glycan metabolism as a potential new therapeutic target in Alzheimer’s disease.

uniQure may seek approval in the UK first while in talks with the FDA about its request for a larger, sham-controlled trial of the one-time, invasive gene therapy AMT-130.

Multiple frontal release signs among cognitively normal older adults are associated with a higher risk for dementia and faster cognitive decline.

Alzheimer’s drug development now targets tau, neuroinflammation, metabolism, and synaptic dysfunction — expanding beyond amyloid toward precision medicine and combination therapy.

Vomiting during a migraine attack is associated with relief or freedom from pain in more than half of patients, a new study shows.

News All Time

Most ‘Sleep-Divorced’ Couples Support Sleeping Separately

A study in Brazil reveals the prevalence and attitudes among couples not driven by relationship stress toward ‘sleep divorce’ arrangements.

Experimental Drug Cuts Migraine Days in Mid-stage Trial

Denmark's Lundbeck said on Thursday its experimental drug bocunebart cut monthly migraine days in ⁠a mid-stage study, supporting further development of a new type of...

Spinal Cord Treatment Triggers Hope and Lawsuits in Brazil

An experimental treatment for spinal cord injuries is drawing patients from as far as Mexico, mobilizing the government to expedite approval before its safety has been proven in a clinical trial.

Global Lewy Body Dementia Incidence: New Data

The first known analysis of pooled worldwide population-based data on dementia with Lewy bodies shows incidence is higher than that of other uncommon neurological disorders.

Comorbid Illness Common in Functional Neurologic Disorder

Functional neurologic disorder has a higher mortality rate than multiple sclerosis and often occurs with comorbid neurologic and psychiatric disorders, a new study shows.

First Clear Win for BTK Inhibitors in Relapsing MS

After previous disappointments with BTK inhibitors, a novel drug in this class is the first to show superiority to an active comparator for relapsing MS outcomes.

Primary Care Making More Mental Health Diagnoses for Kids

Pediatric mental health visits in primary care surged over a 9-year period.

Electroacupuncture Promising for Cognitive Improvement in AD

Electroacupuncture was associated with long-term efficacy in improving cognitive function compared to sham treatment in patients with Alzheimer’s disease, a new trial shows.

Undiagnosed Dementia Tied to Increased Mortality Risk

Undiagnosed dementia is highly prevalent in the US and Brazil and is linked to increased 4-year mortality in both countries, a large cohort study shows.

Coffee Linked to Better Cognition in Patients With PD

Coffee consumption is associated with improved executive function in patients with early Parkinson’s disease, while smoking has no impact, a new study suggests.

How One Psilocybin Trip May Reshape the Brain

New research suggests a single high dose of psilocybin alters neural activity and may trigger lasting structural brain changes tied to improved well-being.

Brain Cooling Boosts LVO Recovery After Thrombectomy

Targeted intra-arterial cooling delivered during clot retrieval significantly increases functional independence after large-vessel ischemic stroke, with no added risk.

Optimal Sleep May Lower Dementia Risk in Focal Epilepsy

Optimal sleep duration is tied to better cognition and a lower risk for dementia in adults with focal epilepsy than in healthy individuals, new research shows.

AHA Reframes Brain Health as a Lifelong Process

A new AHA scientific statement says sleep, mental health, pollution, and childhood adversity can shape cognitive aging and dementia risk, underscoring that brain health is built across a lifetime.

A Stepwise Approach Can Support Healthy Sleep in Children

Minimize the use of medications that counteract melatonin as well as stimulating activities that trigger cortisol, one researcher advised.

Roche Gets Second European Approval for Alzheimer's Test

Swiss drugmaker Roche has received the CE mark - a ⁠European regulatory clearance allowing sale in the region - for its second ⁠Elecsys blood test for Alzheimer's disease.

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