Exploring the role of T cells in Alzheimer's disease, suggests new treatment strategies

Published Date: 10 Mar 2023

Nearly two dozen clinical trials targeting the immune system are in clinical trials for Alzheimer's disease.

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Huntington Therapy Faces Regulatory Roller Coaster

uniQure may seek approval in the UK first while in talks with the FDA about its request for a larger, sham-controlled trial of the one-time, invasive gene therapy AMT-130.

Simple Reflex Exam May Predict Future Dementia Risk

Multiple frontal release signs among cognitively normal older adults are associated with a higher risk for dementia and faster cognitive decline.

Beyond Amyloid: What’s in the Pipeline for Alzheimer’s?

Alzheimer’s drug development now targets tau, neuroinflammation, metabolism, and synaptic dysfunction — expanding beyond amyloid toward precision medicine and combination therapy.

Vomiting During Migraine Attacks Tied to Rapid Pain Relief

Vomiting during a migraine attack is associated with relief or freedom from pain in more than half of patients, a new study shows.

In MS, Stem Cell Transplant Sometimes Looks Like Cure

Autologous hematopoietic stem cell transplant at experienced centers in the current era can include indefinite disease control with low relative risk, a new update suggests.

Brief Brain Stimulation Effective for Depression in PD

Intermittent theta-burst stimulation matches the efficacy of standard transcranial magnetic stimulation for depression in Parkinson’s disease but with a shorter treatment time, new research shows.

Todays Updates

Inside the Major Findings From the NHS-Galleri Trial

The largest randomized study of a multicancer blood test found no reduction in late-stage cancers, while raising new questions about stage shift, mortality benefit, and population screening.

Talquetamab Combos Show Survival Benefit in r/r Myeloma

Interim findings from the phase 3 MonumenTAL-3 trial highlight overall and progression-free survival as well as response rates compared with standard therapy.

Todays Updates

Inside the Major Findings From the NHS-Galleri Trial

The largest randomized study of a multicancer blood test found no reduction in late-stage cancers, while raising new questions about stage shift, mortality benefit, and population screening.

Talquetamab Combos Show Survival Benefit in r/r Myeloma

Interim findings from the phase 3 MonumenTAL-3 trial highlight overall and progression-free survival as well as response rates compared with standard therapy.

Latest News

uniQure may seek approval in the UK first while in talks with the FDA about its request for a larger, sham-controlled trial of the one-time, invasive gene therapy AMT-130.

Multiple frontal release signs among cognitively normal older adults are associated with a higher risk for dementia and faster cognitive decline.

Alzheimer’s drug development now targets tau, neuroinflammation, metabolism, and synaptic dysfunction — expanding beyond amyloid toward precision medicine and combination therapy.

Vomiting during a migraine attack is associated with relief or freedom from pain in more than half of patients, a new study shows.

Autologous hematopoietic stem cell transplant at experienced centers in the current era can include indefinite disease control with low relative risk, a new update suggests.

Intermittent theta-burst stimulation matches the efficacy of standard transcranial magnetic stimulation for depression in Parkinson’s disease but with a shorter treatment time, new research shows.

News All Time

Spinal Cord Treatment Triggers Hope and Lawsuits in Brazil

An experimental treatment for spinal cord injuries is drawing patients from as far as Mexico, mobilizing the government to expedite approval before its safety has been proven in a clinical trial.

Global Lewy Body Dementia Incidence: New Data

The first known analysis of pooled worldwide population-based data on dementia with Lewy bodies shows incidence is higher than that of other uncommon neurological disorders.

Comorbid Illness Common in Functional Neurologic Disorder

Functional neurologic disorder has a higher mortality rate than multiple sclerosis and often occurs with comorbid neurologic and psychiatric disorders, a new study shows.

First Clear Win for BTK Inhibitors in Relapsing MS

After previous disappointments with BTK inhibitors, a novel drug in this class is the first to show superiority to an active comparator for relapsing MS outcomes.

Primary Care Making More Mental Health Diagnoses for Kids

Pediatric mental health visits in primary care surged over a 9-year period.

Electroacupuncture Promising for Cognitive Improvement in AD

Electroacupuncture was associated with long-term efficacy in improving cognitive function compared to sham treatment in patients with Alzheimer’s disease, a new trial shows.

Undiagnosed Dementia Tied to Increased Mortality Risk

Undiagnosed dementia is highly prevalent in the US and Brazil and is linked to increased 4-year mortality in both countries, a large cohort study shows.

Coffee Linked to Better Cognition in Patients With PD

Coffee consumption is associated with improved executive function in patients with early Parkinson’s disease, while smoking has no impact, a new study suggests.

How One Psilocybin Trip May Reshape the Brain

New research suggests a single high dose of psilocybin alters neural activity and may trigger lasting structural brain changes tied to improved well-being.

Brain Cooling Boosts LVO Recovery After Thrombectomy

Targeted intra-arterial cooling delivered during clot retrieval significantly increases functional independence after large-vessel ischemic stroke, with no added risk.

Optimal Sleep May Lower Dementia Risk in Focal Epilepsy

Optimal sleep duration is tied to better cognition and a lower risk for dementia in adults with focal epilepsy than in healthy individuals, new research shows.

A Stepwise Approach Can Support Healthy Sleep in Children

Minimize the use of medications that counteract melatonin as well as stimulating activities that trigger cortisol, one researcher advised.

AHA Reframes Brain Health as a Lifelong Process

A new AHA scientific statement says sleep, mental health, pollution, and childhood adversity can shape cognitive aging and dementia risk, underscoring that brain health is built across a lifetime.

FDA Approves Ocrelizumab for Pediatric Relapsing MS

The FDA approval makes ocrelizumab a new treatment option for children aged 10 years and older with relapsing-remitting multiple sclerosis.

Roche Gets Second European Approval for Alzheimer's Test

Swiss drugmaker Roche has received the CE mark - a ⁠European regulatory clearance allowing sale in the region - for its second ⁠Elecsys blood test for Alzheimer's disease.

Multimodal Approach Can Manage Depression in Children

Psychotherapy is the intervention of first choice, and pharmacotherapy can be considered when psychotherapy alone is not effective, one psychiatrist says.

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