NeurologyLive® Year in Review 2025: Notable Trials Beginning This Year NeurologyLive® Staff

Published Date: 27 Dec 2025

As part of NeurologyLive®'s Year in Review 2025, we've compiled some notable trials that began in 2025.

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Latest News

Primary Care Making More Mental Health Diagnoses for Kids

Pediatric mental health visits in primary care surged over a 9-year period.

Electroacupuncture Promising for Cognitive Improvement in AD

Electroacupuncture was associated with long-term efficacy in improving cognitive function compared to sham treatment in patients with Alzheimer’s disease, a new trial shows.

Undiagnosed Dementia Tied to Increased Mortality Risk

Undiagnosed dementia is highly prevalent in the US and Brazil and is linked to increased 4-year mortality in both countries, a large cohort study shows.

Coffee Linked to Better Cognition in Patients With PD

Coffee consumption is associated with improved executive function in patients with early Parkinson’s disease, while smoking has no impact, a new study suggests.

How One Psilocybin Trip May Reshape the Brain

New research suggests a single high dose of psilocybin alters neural activity and may trigger lasting structural brain changes tied to improved well-being.

Brain Cooling Boosts LVO Recovery After Thrombectomy

Targeted intra-arterial cooling delivered during clot retrieval significantly increases functional independence after large-vessel ischemic stroke, with no added risk.

Todays Updates

EMA Backs Breast Cancer SERD After FDA No Vote

The recommendation follows phase 3 data showing longer progression-free survival when patients switched to camizestrant plus a CDK4/6 inhibitor.

Datopotamab Deruxtecan Earns New Breast Cancer Indication

The antibody drug conjugate was approved by the FDA for certain patients with triple-negative breast cancer.

Todays Updates

EMA Backs Breast Cancer SERD After FDA No Vote

The recommendation follows phase 3 data showing longer progression-free survival when patients switched to camizestrant plus a CDK4/6 inhibitor.

Datopotamab Deruxtecan Earns New Breast Cancer Indication

The antibody drug conjugate was approved by the FDA for certain patients with triple-negative breast cancer.

Latest News

Pediatric mental health visits in primary care surged over a 9-year period.

Electroacupuncture was associated with long-term efficacy in improving cognitive function compared to sham treatment in patients with Alzheimer’s disease, a new trial shows.

Undiagnosed dementia is highly prevalent in the US and Brazil and is linked to increased 4-year mortality in both countries, a large cohort study shows.

Coffee consumption is associated with improved executive function in patients with early Parkinson’s disease, while smoking has no impact, a new study suggests.

New research suggests a single high dose of psilocybin alters neural activity and may trigger lasting structural brain changes tied to improved well-being.

Targeted intra-arterial cooling delivered during clot retrieval significantly increases functional independence after large-vessel ischemic stroke, with no added risk.

News All Time

CTAD: Clinical Trials on Alzheimer's Disease Conference

The New Standard in Multiple Sclerosis: Integrating Evolving Treatment Evidence and Biomarkers to Target Progression

The New Standard in Multiple Sclerosis: Integrating Evolving Treatment Evidence and Biomarkers to Target Progression

Decoding Multifocal Motor Neuropathy: A Practical Guide to Diagnosis, Pathogenesis, and Emerging Innovations in Treatment

Decoding Multifocal Motor Neuropathy: A Practical Guide to Diagnosis, Pathogenesis, and Emerging Innovations in Treatment

AAN: American Academy of Neurology

ISC: International Stroke Conference

CTAD Video Pearls: Video Pearls from the Clinical Trials on Alzheimer's Disease Conference

AES: American Epilepsy Society

Severe Malaria in Kids Linked to Certain Cognitive, Academic Deficits Years Later

Impairment persisted after episodes of cerebral malaria or severe malarial anemia

Rat Lungworm Is Now in My State. Is It in Yours Too?

The global, brain-invading parasite continues to spread

Suppressing a Sneeze May Have Led to Cerebrospinal Fluid Leak

While normally harmless, holding in a sneeze may in rare cases cause serious problems

Novel Agent Reduces Seizures in Treatment-Resistant Epilepsy

Adjunctive azetukalner cut monthly focal onset seizure frequency by 53% in phase III study

Cemdisiran siRNA Therapy Demonstrates Efficacy in Myasthenia Gravis

Investigational treatment improves outcomes without complete complement blockade

First Clinical Trial in MOGAD Meets Primary Endpoint

Satralizumab cuts relapse risk in myelin oligodendrocyte glycoprotein antibody-associated disease

Stiff Person Syndrome Patients Regain Mobility After Single-Dose Cell Therapy

CAR-T therapy shows promise in clinical trial

Cell Therapy Slows Upper Limb Decline in Duchenne Muscular Dystrophy

Investigational deramiocel is back under FDA review again

Real-World Registry Study Shows Alzheimer's Drug Safety Outcomes

No new signals for lecanemab emerged in ALZ-NET

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Vepdegestrant Earns FDA Nod for ESR1-Mutated Breast Cancer

How the skin cancer virus outperforms the replication of host cells.

BTK Inhibitor Active in Half of Patients With Richter Transformation

New Standard of Care in High-Risk Acute Promyelocytic Leukemia?

Cardiomyocytes are shielded from chemotherapy damage by mitochondrial proteins.

Specialized imaging improves overall prostate cancer survival by identifying benefits of salvage radiotherapy

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