FDA Clears IND Application for Zabalafin Hydrogel Treatment of Atopic Dermatitis

Published Date: 23 Feb 2025

Alpyn’s Investigational New Drug application’s clearance by the FDA for the new Zabalafin Hydrogel for atopic dermatitis follows positive phase 2a clinical findings.

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Metabolic Issues Show Up Early and Often With ARPI Therapy

A new study underscores the importance of monitoring patients’ cardiometabolic health soon after starting ADT plus ARPI therapy for prostate cancer.

Women Make Up Small Percentage of Trial Leaders for SHD

Women make up less than 10% of oversight committee seats for interventional structural heart disease trials, although women are being studied more intently than ever before.

Brain Networks Tied to Post-Stroke Dizziness

A lesion network analysis reveals cerebellar and occipital regions consistently associated with dizziness after ischemic stroke, regardless of lesion location or symptom subtype.

AI Stethoscopes May Aid Early CVD Detection

AI-powered stethoscopes are showing promise in primary care, with new evidence suggesting improved detection of heart failure, atrial fibrillation, and valvular disease.

NOACs Tied to Slower Cognitive Decline in Comorbid AF and AD

Non-vitamin K oral anticoagulant use was associated with modestly slower cognitive decline and lower risks for death and stroke in adults with comorbid Alzheimer’s disease and atrial fibrillation.

Acromegaly-Associated Diabetes Tied to Cardiovascular Issues

Patients with acromegaly-associated diabetes face a higher risk for cardiovascular morbidity, but not mortality, than those with type 2 diabetes.

Todays Updates

Belgian Algorithm Reshapes Endometrial Cancer Care

A new Belgian algorithm may help clinicians choose adjuvant therapy more precisely in early endometrial cancer, moving beyond TNM staging alone.

Todays Updates

Belgian Algorithm Reshapes Endometrial Cancer Care

A new Belgian algorithm may help clinicians choose adjuvant therapy more precisely in early endometrial cancer, moving beyond TNM staging alone.

Latest News

A new study underscores the importance of monitoring patients’ cardiometabolic health soon after starting ADT plus ARPI therapy for prostate cancer.

Women make up less than 10% of oversight committee seats for interventional structural heart disease trials, although women are being studied more intently than ever before.

A lesion network analysis reveals cerebellar and occipital regions consistently associated with dizziness after ischemic stroke, regardless of lesion location or symptom subtype.

AI-powered stethoscopes are showing promise in primary care, with new evidence suggesting improved detection of heart failure, atrial fibrillation, and valvular disease.

Non-vitamin K oral anticoagulant use was associated with modestly slower cognitive decline and lower risks for death and stroke in adults with comorbid Alzheimer’s disease and atrial fibrillation.

Patients with acromegaly-associated diabetes face a higher risk for cardiovascular morbidity, but not mortality, than those with type 2 diabetes.

News All Time

Dexrazoxane May Preserve LV Function in Cancer Survivors

Researchers analyzed echocardiographic data from patients who received dexrazoxane before doxorubicin as part of their treatment for cancer in childhood.

Postpartum Health Coaching Boosts Blood Pressure Control

Health coaching may help close a critical gap in care after a hypertensive pregnancy.

Five Steps to Earlier Heart Failure Detection

Heart failure often hides behind vague complaints. These five primary care steps can help spot it earlier and guide faster, evidence-based treatment.

How to Talk About Exercise When Weight Loss Is Off the Table

In the era of GLP-1 drugs, weight loss is no longer a compelling pitch. Here’s how to reframe physical activity for patients.

Central Adiposity May Reclassify CVD Risk Beyond BMI

Among individuals with normal BMI, elevated waist circumference or waist-to-hip ratio may identify cardiovascular risk beyond BMI.

Allopurinol Offers No Heart Benefit in Kidney Donors

The use of allopurinol leads to significantly lower uric acid levels but shows no effect on heart mass, blood pressure, or insulin sensitivity in healthy living kidney donors, a phase 2b trial finds.

Quarter of Gestational Diabetes Moms Get Early Hypertension

More than 1 in 4 women with recent gestational diabetes developed hypertension at 5 months postpartum, driven primarily by baseline maternal characteristics rather than pregnancy complications.

Cardiometabolic Index Can Predict Mortality Risk in T2D

A higher cardiometabolic index is linked to an increased risk for all-cause and cardiovascular mortality in patients with T2D, serving as an effective prognostic tool.

Retatrutide Trims Weight and A1c in Diabetes

Retatrutide helped patients lose up to 30% of body weight in new trials, among the largest effects yet from a weight-loss drug – but a new safety signal raises questions.

Three Midlife Risk Factors Linked to Earlier Dementia Onset

Smoking, diabetes, and hypertension in midlife are associated with nearly 13 fewer dementia-free years, underscoring the importance of vascular risk management.

Even Low Physical Activity May Lower Stroke Risk in AF

Even low levels of physical activity were linked to lower stroke and mortality risks in atrial fibrillation, with greater benefits generally seen at higher activity levels.

BP Variability Tied to White Matter Lesion Growth

Higher visit-to-visit variability in systolic blood pressure is linked to faster progression of white matter lesions in patients at high cardiovascular risk, a study finds.

Timing of Thrombolysis Matters in Patients With Mild Stroke

In patients with ischaemic stroke, intravenous thrombolysis given within 90 minutes of symptom onset improves functional outcomes, but the benefit fades progressively beyond this window.

Iron Testing Gap Seen in Patients With New Heart Failure

Iron deficiency testing remains inconsistent among patients with incident heart failure in UK primary care, with variation by age, sex, and presence of long-term conditions.

Kids With Obesity: Activity Pattern Tied to Metabolic Health

Children with obesity who exhibit more dynamic movement patterns and less sedentary accumulation show better insulin sensitivity and body composition.

Body Fat Patterns Show Similar T2D Predictive Value

Traditional and newer adiposity measures both moderately predict 20-year diabetes risk in healthy adults, yet dysfunctional tissue markers are slightly better at predicting future cases.

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