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Researchers reveal intricate control system for key immune gene

The immune system faces a delicate balancing act: It must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues.

Genes may predict suicide risk in depression

Depression in young adulthood has a stronger hereditary component and is associated with a higher risk of suicide attempts than depression that begins later in life, according to a new study published in Nature Genetics by ...

AI helps better understand how genetic mutations affect our health

As language models learn to interpret words in a sentence, protein language models learn how amino acids work together within a protein.

Decade-long genome study reveals best practices for managing large DNA databases

At a time when large-scale human genome analysis was not yet common, the Tohoku Medical Megabank Organization (ToMMo) launched its genome cohort study. After 10 years of operating this ambitious project, they are sharing ...

Brain tumor patients miss out on new treatments due to unequal access to tumor freezing and genetic testing, study warns

Molecular and genetic testing has become a game-changer in brain tumor care—shaping diagnosis, guiding treatments and opening doors to new therapies. Once available to a handful of patients, these tests are now rapidly ...

Unlocking key insights into gene expression using a novel mouse model

A newly developed mouse model enables real-time visualization of RNA Polymerase II (RNAP2) during DNA transcription, as reported by researchers from Science Tokyo. The team engineered mice to produce a fluorescent antibody ...

Todays Updates

Cancer care crowdfunding increasingly common, but rarely successful

A growing number of desperate cancer survivors are turning to crowdfunding to help pay for their treatment and living expenses, a new study says.

Traces of bacteria inside brain tumors may affect tumor behavior

Researchers at The University of Texas MD Anderson Cancer Center have uncovered unexpected traces of bacteria within brain tumors. This discovery offers new insights into the environment in which brain tumors grow and sets ...

Todays Updates

Cancer care crowdfunding increasingly common, but rarely successful

A growing number of desperate cancer survivors are turning to crowdfunding to help pay for their treatment and living expenses, a new study says.

Traces of bacteria inside brain tumors may affect tumor behavior

Researchers at The University of Texas MD Anderson Cancer Center have uncovered unexpected traces of bacteria within brain tumors. This discovery offers new insights into the environment in which brain tumors grow and sets ...

Latest News

The immune system faces a delicate balancing act: It must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues.

Depression in young adulthood has a stronger hereditary component and is associated with a higher risk of suicide attempts than depression that begins later in life, according to a new study published in Nature Genetics by ...

As language models learn to interpret words in a sentence, protein language models learn how amino acids work together within a protein.

At a time when large-scale human genome analysis was not yet common, the Tohoku Medical Megabank Organization (ToMMo) launched its genome cohort study. After 10 years of operating this ambitious project, they are sharing ...

Molecular and genetic testing has become a game-changer in brain tumor care—shaping diagnosis, guiding treatments and opening doors to new therapies. Once available to a handful of patients, these tests are now rapidly ...

A newly developed mouse model enables real-time visualization of RNA Polymerase II (RNAP2) during DNA transcription, as reported by researchers from Science Tokyo. The team engineered mice to produce a fluorescent antibody ...

News All Time

Experimental drug blocks key protein to trigger cancer cell self-destruction in lung tumors

NYU Langone Health researchers found that a type of cell death caused by a buildup of highly reactive molecules suppresses lung tumor growth.

CRISPR screen identifies new regulator of androgen receptor in prostate cancer

A poorly characterized protein, historically thought to be a chaperon or enzyme, may actually be a key player in prostate cancer. In a systematic CRISPR screen, scientists from Arc Institute, UCSF, and the Fred Hutchinson ...

Study identifies key genes linked to aggressive prostate cancer in people of African descent

New prostate cancer research from an international team led by the Center for Genetic Epidemiology at the Keck School of Medicine of USC has yielded discoveries that could improve screening and treatment for patients of African ...

Bowel cancer's 'Big bang': How a crucial moment determines future growth

Like the astronomical explosion that kickstarted the universe, bowel cancer has a "Big Bang" moment which determines how it will grow, according to new research.

DNA discovery could help identify mothers at risk of pre-eclampsia

The human genome is riddled with relics of viral infections—bits of DNA from viruses that have been inserted in human DNA over millions of years and never left. Most are silent but some have taken on functional roles, particularly ...

Japanese public expresses strong reluctance to donate cells for human brain organoid research

Research on human brain organoids (HBOs) is directly challenging how biobanks and biomedical institutes recruit volunteers. That is what a new study by Japanese researchers in Frontiers in Genetics concludes after finding ...

Hidden nuclear droplets link multiple leukemias and reveal a new therapeutic target

A hidden structure inside the cell is rewriting how scientists understand leukemia. Beneath the microscope, what looked like disorder turned out to follow a simple physical rule—one that connects several major mutations ...

Protein plays unexpected dual role in protecting brain from oxidative stress damage

New research from Johns Hopkins Medicine shows that the enzyme biliverdin reductase A (BVRA) plays a direct protective role against oxidative stress in neurons, independent of its role producing the yellow pigment bilirubin.

Abnormal transport signal on mutant UBTF gene drives high-risk acute myeloid leukemia

Acute myeloid leukemia driven by tandem duplications within the UBTF gene (UBTF-TD AML) is a high-risk pediatric cancer in urgent need of novel therapeutic options. To better understand this disease and how to treat it, St. ...

A new tool for understanding chromosome abnormalities in the eggs of older women

Human egg cells are often prone to chromosomal errors. As women age, the error rate increases sharply—and can contribute to infertility, pregnancy loss, and genetic disorders. Yet why this sudden rise happens remains unknown.

Safe new target against acute myeloid leukemia discovered

Targeting a specialized group of histones is safe and opens new therapeutic opportunities for treating blood cancers. This is the main finding of the latest research by Dr. Marcus Buschbeck and Dr. René Winkler, researchers ...

How a tiny RNA molecule in the kidney triggers a deadly autoimmune disease

Researchers at the University Hospital Bonn (UKB) and the University of Bonn have discovered how a small, naturally occurring RNA molecule in the kidney activates a mutated immune receptor, triggering a chain reaction.

Scientists find the genetic clues that let humans walk on two legs

Two small changes in human DNA may have played a big role in helping our ancestors walk upright, researchers say.

New clue to ALS and FTD: Faulty protein disrupts brain's 'brake' system

A new Northwestern University study using patient nervous tissue and lab-grown human neurons has uncovered how a key disease protein, TDP-43, drives overactive nerve cells in the neurodegenerative diseases amyotrophic lateral ...

BRCA2 research reveals a novel mechanism behind chemoresistance

One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often limited.

Genes associated with obesity shared across ancestries, researchers find

Obesity is a global epidemic affecting millions of people every day and is associated with comorbidities ranging from heart disease and type 2 diabetes to osteoarthritis and social stigma. While lifestyle factors, like diet ...

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