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Study reveals epigenetic mechanisms regulating ILC2 memory and asthma recurrence

Researchers have revealed a novel mechanism by which the chromatin remodeler brahma-related gene 1 (Brg1) regulates Group 2 innate lymphoid cells (ILC2s) in allergic lung inflammation. Brg1 exacerbates allergic lung inflammation ...

'Guided missile' drug molecule seeks out and destroys cancer's genetic lifeline

Researchers have created a new type of drug molecule that can precisely destroy TERRA, an RNA molecule that helps certain cancer cells survive. Using advanced "RIBOTAC" technology, their compound finds TERRA inside cells ...

A new developmental disorder—variations in the UNC13A gene can cause neurological impairments in children

Whether we are writing an email, rushing for a bus, or humming a tune, every thought, feeling, and action relies on communication between our roughly 100 billion nerve cells. This exchange of information happens at synapses, ...

TBRG4 identified as marker of poor survival and driver of tumor progression in lung adenocarcinoma

Lung adenocarcinoma (LUAD) is the most common form of lung cancer, accounting for nearly half of cases. Many patients are diagnosed at advanced stages, and five-year survival remains below 20%.

The role of genetics in modifying the link between earlier menopause and memory decline

Women are significantly more likely than men to develop Alzheimer's disease. Earlier age at menopause is associated with a greater risk for late-life cognitive decline and Alzheimer's disease. A new study suggests that this ...

Gene deficiency that causes obesity also protects from heart disease, finds new study

Deficiency of the gene melanocortin 4 receptor (MC4R) is linked with obesity among adults. A recent study has found that the same deficiency also leads to surprising outcomes such as reduced risk of heart disease, lower cholesterol, ...

Todays Updates

Medicaid expansion tied to smaller declines in early-stage cancer detection

During the COVID-19 pandemic, Medicaid expansion was associated with smaller declines in early-stage cancer detection, according to a study published online Oct. 21 in the Journal of the National Cancer Institute.

Toward rapid and comprehensive genetic diagnosis of pediatric cancer through adaptive sequencing

What if a single test could simultaneously contribute to the diagnosis, characterization, and treatment guidance of childhood cancer—while helping avoid toxic or potentially unnecessary treatments?

Todays Updates

Medicaid expansion tied to smaller declines in early-stage cancer detection

During the COVID-19 pandemic, Medicaid expansion was associated with smaller declines in early-stage cancer detection, according to a study published online Oct. 21 in the Journal of the National Cancer Institute.

Toward rapid and comprehensive genetic diagnosis of pediatric cancer through adaptive sequencing

What if a single test could simultaneously contribute to the diagnosis, characterization, and treatment guidance of childhood cancer—while helping avoid toxic or potentially unnecessary treatments?

Latest News

Researchers have revealed a novel mechanism by which the chromatin remodeler brahma-related gene 1 (Brg1) regulates Group 2 innate lymphoid cells (ILC2s) in allergic lung inflammation. Brg1 exacerbates allergic lung inflammation ...

Researchers have created a new type of drug molecule that can precisely destroy TERRA, an RNA molecule that helps certain cancer cells survive. Using advanced "RIBOTAC" technology, their compound finds TERRA inside cells ...

Whether we are writing an email, rushing for a bus, or humming a tune, every thought, feeling, and action relies on communication between our roughly 100 billion nerve cells. This exchange of information happens at synapses, ...

Lung adenocarcinoma (LUAD) is the most common form of lung cancer, accounting for nearly half of cases. Many patients are diagnosed at advanced stages, and five-year survival remains below 20%.

Women are significantly more likely than men to develop Alzheimer's disease. Earlier age at menopause is associated with a greater risk for late-life cognitive decline and Alzheimer's disease. A new study suggests that this ...

Deficiency of the gene melanocortin 4 receptor (MC4R) is linked with obesity among adults. A recent study has found that the same deficiency also leads to surprising outcomes such as reduced risk of heart disease, lower cholesterol, ...

News All Time

Loops of RNA help drive synapse-building during visual system development in young mice

Wiring up the brain's trillions of circuit connections is an enormous job performed by a huge crew of molecules. Among the less understood members are circular RNAs, transcripts from DNA that assume a closed loop shape. A ...

Simple blood test shows promise in detecting amyotrophic lateral sclerosis early

New research by UCLA Health has found a simple blood test could provide faster and more accurate diagnosis of ALS by measuring cell-free DNA. The noninvasive test could not only allow neurologists to rule out other neurological ...

Detailed structure of key hearing protein points way to optimizing gene therapies for deafness

Researchers in Göttingen, Germany, have elucidated the structure and function of otoferlin, a protein that plays a crucial role in the hearing process. Loss of otoferlin or impairment of its function causes a frequent form ...

New genetic variant linked to hereditary optic atrophy and vision loss

A research team from the Medical University of Vienna and the Medical University of Graz has discovered a previously unknown genetic cause of hereditary optic atrophy, a degenerative disease of the optic nerve associated ...

Novel mechanism underlies chemotherapy sensitivity in aggressive bone cancer

A research team at the Seville Biomedical Institute (IBis) has identified a new molecular mechanism that explains the high sensitivity of Ewing sarcoma (an aggressive bone cancer that mainly affects children and adolescents) ...

Cancer cells reactivate embryo-like gene editors to fuel growth, research reveals

Cancer cells are known to reawaken embryonic genes to grow. A new study reveals the disease also hijacks the proteins, or "editors," that control how those genes are read.

Researchers show benefit of ultra-deep RNA sequencing in Mendelian disorder diagnostics

RNA sequencing (RNA-seq) is a powerful tool in diagnosing Mendelian disorders, but the optimized sequencing depth for this technology has not yet been determined. In a new study published in the American Journal of Human ...

New research identifies more accurate way of predicting which blood cancer patients will relapse early

A study carried out by a team of researchers from The Institute of Cancer Research, London, found that combining two types of genetic tests gives doctors a much better chance of identifying multiple myeloma patients who are ...

Hidden patterns link ribosomal RNAs to genes of the nervous system

New research has uncovered shared patterns between ribosomal RNAs and genes linked to brain disorders, including autism, bipolar disorder, ADHD, and schizophrenia.

Fruit fly study reveals genetic targets for rare childhood brain cancer treatment

Using fruit flies, University of Wisconsin–Madison researchers have developed a new model for investigating the genetic drivers of a rare but aggressive brain tumor in children. The work has already identified potential ...

Scientists discover gene mutation linked to deafness—and identify possible treatments

Mutations in a gene known as CPD play a crucial role in a rare form of congenital hearing loss, an international team of researchers has discovered.

Absence of key protein scrambles sperm DNA, revealing potential cause of male infertility

Researchers from the Universitat Autònoma de Barcelona (UAB) have published an analysis that reveals new functions of the RAD21L protein—a germline-specific cohesin—crucial for male fertility. The study, carried out ...

New world record set for fastest human whole genome sequencing

Boston Children's Hospital, along with Broad Clinical Labs and Roche Sequencing Solutions, has demonstrated that rapid genomic sequencing and interpretation are achievable in a matter of hours. This milestone not only sets ...

Gene therapy delivers lasting immune protection in children with rare disorder

An experimental gene therapy developed by researchers at UCLA, University College London and Great Ormond Street Hospital has restored and maintained immune system function in 59 of 62 children born with ADA-SCID, a rare ...

Why women's brains face higher risk: Scientists pinpoint X-chromosome gene behind MS and Alzheimer's

New research by UCLA Health has identified a sex-chromosome linked gene that drives inflammation in the female brain, offering insight into why women are disproportionately affected by conditions such as Alzheimer's disease ...

Newly identified function for protein could hold key to chemo resistance

A University of Alberta research team has uncovered a new role for a genetic mutation previously known to be linked to developmental disorders—and it could hold the key to more effective treatments and improved outcomes ...

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