Tracing a rare muscle disorder back to a mutation in a noncoding gene

Published Date: 02 Mar 2023

A research team from Massachusetts General Hospital (MGH), a founding member of Mass General Brigham (MGB) and Mass General for Children (MGfC), has identified a mutation in a non-first time.

Read Full News

Latest News

Molecule that could cause COVID clotting key to new treatments

In a surprising discovery, a "sticky molecule" that occurs naturally in our blood vessels could be both a culprit behind blood clots and organ failure during COVID and long COVID and the key to new treatments to counter COVID-related ...

New potential gene-based treatment for sepsis and lung injury

A new discovery from the lab of YouYang Zhao, Ph.D., from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, opens promising new directions for treatment of life-threatening ...

DNA methylation patterns in newborns point to susceptibility to schizophrenia

Genetic susceptibility to neurodevelopmental conditions such as schizophrenia, autism, and ADHD can be linked, in part, to distinct epigenetic signatures in newborn cord blood. An analysis of nearly 6,000 newborns published ...

CRISPR breakthrough reverses chemotherapy resistance in lung cancer

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach ...

Fertility treatments linked to higher mutations than natural conception in mice

Mice pups conceived with in vitro fertilization (IVF) in the lab have slightly increased rates of DNA errors, or mutations, compared to pups conceived naturally, a new study on artificial reproductive technologies suggests.

A time-sensitive genetic switch for sex-specific features of developing neurons

Researchers have identified that the precisely timed transcription of two genes named grim and reaper is responsible for the targeted death of neurons within the developing nervous system of female flies. This group of neurons ...

Todays Updates

Rural Accountable Care Organizations: Better Diabetes Care

Participation in accountable care organizations shows better diabetes care outcomes for patients in rural areas than for those in urban settings.

Sex Disparity Seen in Response to Growth Therapy in 21-OHD

In patients with classical 21-hydroxylase deficiency, growth-promoting therapies have variable effects: They increase final height relative to midparental height in boys but not in girls.

Higher Relative Fat Mass Is Linked With Chronic Diarrhea

Higher relative fat mass is associated with increased odds of having chronic diarrhea, although the measure alone shows limited ability to predict risk.

Diabetes in Mothers Tied to Epilepsy Risk in Offspring

Risk rises with all three types of diabetes mellitus but mostly with type 2.

Managing Constipation in Patients on GLP-1s

As GLP-1 use rise, constipation remains a leading cause of discontinuation. Experts offer practical strategies for prevention and management.

Dapagliflozin Can Reduce Liver Fat in Diabetes

In patients with type 2 diabetes, 12 months of dapagliflozin therapy is significantly associated with reduced liver fat, independent of weight loss or other metabolic benefits.

Diabetes Remission Is Possible, but There’s Not Just One Way

Physicians must deploy specific tools in specific ways at specific times — adding to the time-consuming treatment costs.

Todays Updates

Rural Accountable Care Organizations: Better Diabetes Care

Participation in accountable care organizations shows better diabetes care outcomes for patients in rural areas than for those in urban settings.

Sex Disparity Seen in Response to Growth Therapy in 21-OHD

In patients with classical 21-hydroxylase deficiency, growth-promoting therapies have variable effects: They increase final height relative to midparental height in boys but not in girls.

Higher Relative Fat Mass Is Linked With Chronic Diarrhea

Higher relative fat mass is associated with increased odds of having chronic diarrhea, although the measure alone shows limited ability to predict risk.

Diabetes in Mothers Tied to Epilepsy Risk in Offspring

Risk rises with all three types of diabetes mellitus but mostly with type 2.

Managing Constipation in Patients on GLP-1s

As GLP-1 use rise, constipation remains a leading cause of discontinuation. Experts offer practical strategies for prevention and management.

Dapagliflozin Can Reduce Liver Fat in Diabetes

In patients with type 2 diabetes, 12 months of dapagliflozin therapy is significantly associated with reduced liver fat, independent of weight loss or other metabolic benefits.

Diabetes Remission Is Possible, but There’s Not Just One Way

Physicians must deploy specific tools in specific ways at specific times — adding to the time-consuming treatment costs.

Latest News

In a surprising discovery, a "sticky molecule" that occurs naturally in our blood vessels could be both a culprit behind blood clots and organ failure during COVID and long COVID and the key to new treatments to counter COVID-related ...

A new discovery from the lab of YouYang Zhao, Ph.D., from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, opens promising new directions for treatment of life-threatening ...

Genetic susceptibility to neurodevelopmental conditions such as schizophrenia, autism, and ADHD can be linked, in part, to distinct epigenetic signatures in newborn cord blood. An analysis of nearly 6,000 newborns published ...

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach ...

Mice pups conceived with in vitro fertilization (IVF) in the lab have slightly increased rates of DNA errors, or mutations, compared to pups conceived naturally, a new study on artificial reproductive technologies suggests.

Researchers have identified that the precisely timed transcription of two genes named grim and reaper is responsible for the targeted death of neurons within the developing nervous system of female flies. This group of neurons ...

News All Time

Surprising blood stem cell diversification revealed in humans

Every second, millions of blood cells are produced in the human body, and about 90% of the cells replaced daily are blood cells. These include red blood cells essential for oxygen transport, platelets for blood clotting, ...

Q&A: Research offers hope for new autoimmune treatments

Alec Whited ('25 MS, Biology) is helping uncover how cells remove waste, a process that could lead to better treatments for autoimmune diseases and improved wound healing.

Tracking RNA levels reveals new clues in triple-negative breast cancer progression

When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer's development or ...

New clinical practice resource on managing RAD51C, RAD51D, and BRIP1 variants released

The American College of Medical Genetics and Genomics (ACMG) has published a new clinical practice resource, "Management of Individuals with Heterozygous Germline Pathogenic Variants in RAD51C, RAD51D, and BRIP1: A clinical ...

Should kids be screened for high cholesterol genes? Study weighs costs and benefits

In the United States, 1 in every 250 people has inherited a genetic variant that leads to dangerously high cholesterol levels from birth.

James Watson helped crack DNA's code, sparking medical advances and ethical debates

On a foggy Saturday morning in 1953, a tall, skinny 24-year-old man fiddled with shapes he had cut out of cardboard. They represented fragments of a DNA molecule, and young James Watson was trying to figure how they fit together ...

Breast cancer relapse: Key cellular resistance mechanism discovered

Triple-negative breast cancer is one of the most aggressive and difficult cancers to treat. It can initially respond well to therapeutic combinations of chemotherapy, but a tiny minority of tumor cells may manage to tolerate ...

Genetically altered hair cells show how inner ear structures are organized

Northwestern Medicine scientists have uncovered how a specific type of cell in the inner ear plays a commanding role in shaping the cellular landscape of the organ responsible for hearing, according to a study published in ...

Key histone variant may explain some forms of infertility

An epigenetic factor that is essential for producing mature egg cells in mice has been identified by RIKEN researchers for the first time. This discovery could aid research into cases of infertility caused by immature eggs.

Hundreds of genes act differently in the brains of men and women

Differences between men and women in intelligence and behavior have been proposed and disputed for decades.

CRISPR screen identifies new regulator of androgen receptor in prostate cancer

A poorly characterized protein, historically thought to be a chaperon or enzyme, may actually be a key player in prostate cancer. In a systematic CRISPR screen, scientists from Arc Institute, UCSF, and the Fred Hutchinson ...

Study identifies key genes linked to aggressive prostate cancer in people of African descent

New prostate cancer research from an international team led by the Center for Genetic Epidemiology at the Keck School of Medicine of USC has yielded discoveries that could improve screening and treatment for patients of African ...

Experimental drug blocks key protein to trigger cancer cell self-destruction in lung tumors

NYU Langone Health researchers found that a type of cell death caused by a buildup of highly reactive molecules suppresses lung tumor growth.

Bowel cancer's 'Big bang': How a crucial moment determines future growth

Like the astronomical explosion that kickstarted the universe, bowel cancer has a "Big Bang" moment which determines how it will grow, according to new research.

DNA discovery could help identify mothers at risk of pre-eclampsia

The human genome is riddled with relics of viral infections—bits of DNA from viruses that have been inserted in human DNA over millions of years and never left. Most are silent but some have taken on functional roles, particularly ...

Hidden nuclear droplets link multiple leukemias and reveal a new therapeutic target

A hidden structure inside the cell is rewriting how scientists understand leukemia. Beneath the microscope, what looked like disorder turned out to follow a simple physical rule—one that connects several major mutations ...

Recommended News For You

The amount of liver tissue removed during gallbladder surgery has no discernible impact on overall survival.

Admissions, medical colleges, fees, and eligibility requirements information for the DNB Post Diploma in Radiation Oncology.

Dr. Prerana S. Nesargi's message for Childhood Cancer Awareness Month 2023 is to increase understanding of pediatric oncology.

Housing aid linked to lower medical financial hardship among US renters with cancer

Loneliness and social isolation linked to heightened risk of death in those with cancer

Analysis of 2021 data shows new cancer diagnoses did not rebound as expected following pandemic

Genetics and therapy type determine second cancer risk after childhood treatment, study finds

Recommended Articles For You

Tumor Evolution: Signaling, Plasticity, and Intratumor Heterogeneity in Cancer 

Exploring the Pleomorphic Adenoma: A Unique and Varied Tumor 

Sound Waves and Self-Destruction: A Promising Nanotech Weapon in the Fight Against Cancer 

Using Node Technology to Fight Breast Cancer: A New Hope for Early Detection 

Whats more on Hidoc Dr.

Medical Updates
KOL Videos
Surveys
Events

Daily news to keep you up to date

Gain valuable insights with our in-depth KOL Video discussions

Participate and win cash vouchers

Get updates on the latest events happening around the world
Featured News
Featured Articles
Featured Events
Featured KOL Videos

1.

Housing aid linked to lower medical financial hardship among US renters with cancer

2.

Review looks at potential treatment targets in the tumor microenvironment.

3.

Low-Dose Radiation Provides Almost Perfect Control Over Slow-Growing Lymphoma.

4.

Lower Prostate Cancer Mortality Linked to Unavailable Clinical Trials.

5.

Research indicates that extended PSMA therapy is safe and effective for patients with prostate cancer.

1.

Understanding Hidrocystoma: Symptoms, Causes, and Treatment Options 

2.

All You Need To Know About Cancer Antigen 27-29: Causes, Symptoms & Treatment

3.

Breaking Down Leukocytoclastic Vasculitis: Causes, Symptoms and Treatment

4.

Understanding Sickle Cell Anemia: Causes, Symptoms, and Treatment Options 

5.

Clinical Analysis of Prostate Cancer

1.

International Lung Cancer Congress®

2.

Future NRG Oncology Meeting

3.

Genito-Urinary Oncology Summit 2026

4.

ISMB 2026 (Intelligent Systems for Molecular Biology)

5.

Annual International Congress on the Future of Breast Cancer East

1.

Revolutionizing Treatment of ALK Rearranged NSCLC with Lorlatinib - Part V

2.

Pazopanib: A Game-Changer in Managing Advanced Renal Cell Carcinoma

3.

An Eagles View - Evidence-based discussion on Iron Deficiency Anemia- Important Points to Know

4.

A Comprehensive Guide to First Line Management of ALK Positive Lung Cancer - Part II

5.

A Continuation to The Evolving Landscape of First-Line Treatment for Urothelial Carcinoma

Fastest Growing Medical Platform for Doctors

Address :
Hidoc Dr. Inc. | Delaware C Corp | 1309 Coffeen Ave. Suite 1200, Sheridan WY, 82801

Phone :
+1-415-463-3094

Email :
anishagadia@hidoc.co

Quick Links

Drug DatabaseDrug InteractionDiseases Database
KOL VideosKnowledge HubQuizzes
Medical UpdatesEventsAbout Us

© Copyright 2025 Hidoc Dr. Inc.

Terms & Conditions - LLP | Inc. | Privacy Policy - LLP | Inc. | Account Deactivation
Home
Profile
Login
bot