Blinatumomab May Improve Survival in High-Risk Adult B-ALL

Published Date: 30 Jul 2026

A phase 2 trial evaluates the benefit of adding blinatumomab to consolidation therapy in adults with high-risk Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia.

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The less-intensive drug combination outperforms standard induction chemotherapy in fit patients with acute myeloid leukemia.

The accelerated approval enables an endocrine therapy switch when the ESR1 resistance mutation is detected, rather than waiting for evidence of disease progression.

A study of US women finds no connection between talc powder use and lung cancer, though subgroup findings leave questions open.

The association is driven by higher rates of death from cardiovascular disease and other cancers over 13 years.

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A modest increase in radiation dose improves progression-free survival over 10 years among men with high-risk prostate cancer — but the overall survival benefits found in a French trial are uncertain.

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