7 mars 2023

Published Date: 10 Mar 2023

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Three Midlife Risk Factors Linked to Earlier Dementia Onset

Smoking, diabetes, and hypertension in midlife are associated with nearly 13 fewer dementia-free years, underscoring the importance of vascular risk management.

Even Low Physical Activity May Lower Stroke Risk in AF

Even low levels of physical activity were linked to lower stroke and mortality risks in atrial fibrillation, with greater benefits generally seen at higher activity levels.

Timing of Thrombolysis Matters in Patients With Mild Stroke

In patients with ischaemic stroke, intravenous thrombolysis given within 90 minutes of symptom onset improves functional outcomes, but the benefit fades progressively beyond this window.

BP Variability Tied to White Matter Lesion Growth

Higher visit-to-visit variability in systolic blood pressure is linked to faster progression of white matter lesions in patients at high cardiovascular risk, a study finds.

Kids With Obesity: Activity Pattern Tied to Metabolic Health

Children with obesity who exhibit more dynamic movement patterns and less sedentary accumulation show better insulin sensitivity and body composition.

Iron Testing Gap Seen in Patients With New Heart Failure

Iron deficiency testing remains inconsistent among patients with incident heart failure in UK primary care, with variation by age, sex, and presence of long-term conditions.

Todays Updates

Freeman’s Lobotomy to Deep Brain Stimulation: What Changed?

The history of lobotomy shows the risks for limited evidence and oversight, while modern approaches emphasize targeted treatment, informed consent, and rigorous evaluation.

Wide Variation Seen in Lung Screening False-Positive Rates

US radiologists vary substantially in their reading of low-dose CT lung cancer screens, highlighting a need for measures to help standardize interpretation.

AVD Chemo Regimen Shows Promise in Older Patients With HL

Researchers compare first-line chemotherapy regimens in older patients with classical Hodgkin lymphoma to assess whether AVD is associated with better outcomes in routine care.

Do High-Risk Features of Prostate Cancer Boost HT Benefit?

Researchers analyze individual patient data from five randomized phase 3 trials comparing PORT alone vs PORT plus hormone therapy in patients with recurrent prostate cancer.

How Low Does PSA Need to Go in Metastatic Prostate Cancer?

A new real-world analysis helps clarify the most informative prognostic PSA benchmark in men with metastatic castration-sensitive prostate cancer.

Tissue-Free ctDNA Strongly Prognostic of Recurrence in TNBC

Tissue-free ctDNA may be comparable to tumor-informed assays in detecting molecular residual disease.

Todays Updates

Freeman’s Lobotomy to Deep Brain Stimulation: What Changed?

The history of lobotomy shows the risks for limited evidence and oversight, while modern approaches emphasize targeted treatment, informed consent, and rigorous evaluation.

Wide Variation Seen in Lung Screening False-Positive Rates

US radiologists vary substantially in their reading of low-dose CT lung cancer screens, highlighting a need for measures to help standardize interpretation.

AVD Chemo Regimen Shows Promise in Older Patients With HL

Researchers compare first-line chemotherapy regimens in older patients with classical Hodgkin lymphoma to assess whether AVD is associated with better outcomes in routine care.

Do High-Risk Features of Prostate Cancer Boost HT Benefit?

Researchers analyze individual patient data from five randomized phase 3 trials comparing PORT alone vs PORT plus hormone therapy in patients with recurrent prostate cancer.

How Low Does PSA Need to Go in Metastatic Prostate Cancer?

A new real-world analysis helps clarify the most informative prognostic PSA benchmark in men with metastatic castration-sensitive prostate cancer.

Tissue-Free ctDNA Strongly Prognostic of Recurrence in TNBC

Tissue-free ctDNA may be comparable to tumor-informed assays in detecting molecular residual disease.

Latest News

Smoking, diabetes, and hypertension in midlife are associated with nearly 13 fewer dementia-free years, underscoring the importance of vascular risk management.

Even low levels of physical activity were linked to lower stroke and mortality risks in atrial fibrillation, with greater benefits generally seen at higher activity levels.

In patients with ischaemic stroke, intravenous thrombolysis given within 90 minutes of symptom onset improves functional outcomes, but the benefit fades progressively beyond this window.

Higher visit-to-visit variability in systolic blood pressure is linked to faster progression of white matter lesions in patients at high cardiovascular risk, a study finds.

Children with obesity who exhibit more dynamic movement patterns and less sedentary accumulation show better insulin sensitivity and body composition.

Iron deficiency testing remains inconsistent among patients with incident heart failure in UK primary care, with variation by age, sex, and presence of long-term conditions.

News All Time

Cardiac Output Tied to Brain Volume in APOE-ε4 Carriers

Reduced cardiac output is associated with a smaller brain volume in older adults carrying the APOE-ε4 allele, but not in non-carriers, a study shows.

Braunwald’s Uncertain Beginnings and Concerns for the US

Eugene Braunwald’s life was full of close calls. Medscape spoke with cardiologist Thomas Lee about how he came to write the eminent physician’s biography and the last time he spoke with Braunwald.

Capillary Changes Tied to Higher Mortality in Raynaud's

Patients with early Raynaud's phenomenon who show both abnormal nailfold capillaries and positive antinuclear antibodies face a mortality pattern that diverges from those with neither marker.

Forward Head Posture Linked to Altered Spine Alignment

A radiographic analysis reveals that forward head posture involves shifts in the upper cervical and cervicothoracic regions with increased forward spinal balance.

Kidney Function Tied to Small Vessel Disease Marker

Stroke survivors with glomerular hyperfiltration show more enlarged perivascular spaces, while those with severely reduced kidney function have greater overall small vessel disease burden.

UK Becomes First in Europe to Approve New GLP-1 Pill

The MHRA approves orforglipron, making the UK the first country in Europe to approve the weight-loss and diabetes drug.

Plasma p-Tau217 Drop Tied to Better Outcomes on Lecanemab

Patients with Alzheimer's disease show distinct patterns of plasma p-tau217 reduction after starting lecanemab, and those with greater biomarker drops show more favorable cognitive trajectories.

Premature Menopause Linked to Higher Risk for Hypertension

Premature menopause before the age of 40 years is linked to a higher risk for hypertension than normal menopause after the age of 45 years.

Levothyroxine Aids Heart Health in Kids With Hypothyroidism

Levothyroxine therapy may improve subtle left ventricular diastolic dysfunction in children with idiopathic subclinical hypothyroidism.

Specific Food Ingredients Linked to Risk for Hypertension

Specific food ingredients used in ultraprocessing are linked to a higher risk of developing incident arterial hypertension, a large UK Biobank analysis finds.

Depression Mediates Link Between CAA and Cognitive Decline

Depressive symptoms are more likely in patients with cerebral amyloid angiopathy than in control individuals and partly explain the cognitive deficits in this population.

Smoky Air on Hot Days Linked to More Danger for the Heart

A multi-country study shows the impact of wildfire smoke exposure during a heatwave, prompting calls for cardiologists to protect their most vulnerable patients.

‘Always a Physician’: Retirement’s Biggest Test Isn’t Money

You may stop practicing, but can you stop being a doctor? Physicians say finding an identity in retirement can be a hard pill to swallow, but it’s the most important part.

Launching a Successful YouTube Channel: A Physician Primer

Do you want to educate patients beyond your clinic? Or augment your income? Some physicians have turned to YouTube to achieve these goals. Here’s how to get started.

Medication Management in Older Adults With Cognitive Decline

A qualitative study shows medication management depends on trust, caregiver support, and early recognition of cognitive decline, not memory alone.

Protein Intake and Kidney Function: No Link Found

A decade-long study using precise kidney function measurements challenges concerns about dietary protein harming kidney health in adults largely free of chronic kidney disease.

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A Century of Schizophrenia: One Disorder or Many?

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