7 mars 2023

Published Date: 10 Mar 2023

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The Dark Side of Full Patient Autonomy

Amid the backlash against paternalism and efforts to rebuild trust, an important ethical principle got caught in the fallout: the duty to act in the patient’s best interest.

JAK Inhibitors Linked to Reduced Disease Activity in RA

JAK inhibitors are linked to reduced disease activity and improved patient-reported outcomes in patients with rheumatoid arthritis, regardless of diabetes, cardiometabolic burden, or age.

CDK4/6 Inhibitors: One Class, Three Outcomes

Abemaciclib and ribociclib now show adjuvant survival benefit; palbociclib didn't. Laura Spring, MD, on picking the right agent per patient.

IL-6 May Predict HF Risk in Adults With Obesity and Diabetes

Higher interleukin 6 concentrations are linked to an increased risk for heart failure in adults with type 2 diabetes and overweight or obesity.

Global Definition Breaks MI Into Three Clinical Categories

A new global definition of myocardial infarction will allow cardiologists and other healthcare professionals to improve diagnosis and treatment of patients with the disorder.

‘I Had to Choose’: When Your Medical Career Isn’t Fulfilling

For physicians, a fulfilling career often starts with unlearning the habits that made them successful in medicine — and finding the courage to try.

Todays Updates

First-Line T-DXd Boosts PFS in HER2-Mutant NSCLC

DESTINY-Lung04 supports trastuzumab deruxtecan as a new frontline option for patients with advanced HER2-mutant disease, though it failed to improve overall survival.

Could Burnout Become the Employer’s Responsibility?

A European Parliament committee is backing employer risk assessments to tackle burnout. But should that mean new binding EU rules?

High CLL Remission Seen With First-Line Triplet Regimen

High 2-year survival rates are seen in treatment-naive patients with CLL receiving a noncovalent BTK inhibitor combined with venetoclax and obinutuzumab.

FET-PET Agent Approved for Glioma Imaging

Floretyrosine F18 is the first amino acid PET imaging agent approved for glioma in the United States.

Todays Updates

First-Line T-DXd Boosts PFS in HER2-Mutant NSCLC

DESTINY-Lung04 supports trastuzumab deruxtecan as a new frontline option for patients with advanced HER2-mutant disease, though it failed to improve overall survival.

Could Burnout Become the Employer’s Responsibility?

A European Parliament committee is backing employer risk assessments to tackle burnout. But should that mean new binding EU rules?

High CLL Remission Seen With First-Line Triplet Regimen

High 2-year survival rates are seen in treatment-naive patients with CLL receiving a noncovalent BTK inhibitor combined with venetoclax and obinutuzumab.

FET-PET Agent Approved for Glioma Imaging

Floretyrosine F18 is the first amino acid PET imaging agent approved for glioma in the United States.

Latest News

Amid the backlash against paternalism and efforts to rebuild trust, an important ethical principle got caught in the fallout: the duty to act in the patient’s best interest.

JAK inhibitors are linked to reduced disease activity and improved patient-reported outcomes in patients with rheumatoid arthritis, regardless of diabetes, cardiometabolic burden, or age.

Abemaciclib and ribociclib now show adjuvant survival benefit; palbociclib didn't. Laura Spring, MD, on picking the right agent per patient.

Higher interleukin 6 concentrations are linked to an increased risk for heart failure in adults with type 2 diabetes and overweight or obesity.

A new global definition of myocardial infarction will allow cardiologists and other healthcare professionals to improve diagnosis and treatment of patients with the disorder.

For physicians, a fulfilling career often starts with unlearning the habits that made them successful in medicine — and finding the courage to try.

News All Time

Higher Hemoglobin May Promote Lower Mortality

Large cohort study shows sweet spot at 1-3 g/dL above the WHO threshold.

Prosthetic Valve Endocarditis Differs From Native in Kids

Children with prosthetic valve endocarditis present at an older age and show lower echocardiographic detection than those with native valve disease; complications and surgery are highly frequent.

Intra-amniotic Infection Tied to Early-Onset Neonatal Sepsis

Intra-amniotic infection is associated with early-onset neonatal sepsis in pregnancies complicated by preterm prelabor rupture of membranes.

Prasugrel Falls Short as Default P2Y12 Inhibitor for ACS

It is nearly 20 years since trials of prasugrel and ticagrelor showed better protection over clopidogrel against MACE for ACS, but superiority of one over the other still remains unresolved.

Hormone Therapy: Lower Heart Risk in Women With Hot Flashes

In perimenopausal and recently postmenopausal women experiencing hot flashes and/or night sweats, initiating hormone therapy is associated with a reduction in the risk for cardiovascular events.

Severe Infections Tied to Heart Failure Risk

A hospitalization for severe infection is associated with a higher long-term risk of developing heart failure, yet current risk calculators may underestimate this risk by as much as 9%.

CAC Found to Add Little to PREVENT-ASCVD Risk Prediction

Adding coronary artery calcium to the PREVENT-ASCVD equations only modestly improves risk prediction overall, with the greatest reclassification seen in borderline-risk adults.

More Breast Milk in Infant Diet Aids Maternal Heart Health

A breast milk diet for infants is associated with a dose-response relationship to lower triglyceride levels in mothers.

Xylitol Linked to Increased Long-Term Cardiovascular Risk

The results are likely to sharpen debate over how clinicians should counsel patients about nonsugar sweeteners.

Combined A1c, BP Time in Range Predicts Kidney Outcomes

Patients who maintain target A1c and systolic blood pressure 100% of the time for a year have significantly better kidney outcomes than those in target range 50% of the time or less.

How Common Is Doping in Amateur Sports?

Amateur athletes may underestimate the risks for performance-enhancing substances, highlighting the need for better education and coordinated support from healthcare professionals.

Gestational Age Predicts Neurodevelopmental Outcomes in CHD

Premature infants with congenital heart disease may have worse cognitive and motor development outcomes than those born at term, a cohort study shows.

Persistently High Troponin-T Levels in ACS Tied to HF Risk

Persistently elevated troponin-T levels are linked to a higher risk for heart failure in patients with suspected acute coronary syndrome, a study finds.

PPIs: What Rigorous Data Actually Confirms

Ten PPI products share the same warnings on kidney disease, dementia, fracture, and cancer. Daniela Jodorkovsky, MD, on why study design keeps overturning the alarm.

PARP Inhibitors: Narrower Labels, Wider Reach

Five branded products, four tumor types, and a regulatory arc that walked back late-line ovarian approvals even as AKEEGA just reached hormone-sensitive prostate cancer.

Cardiometabolic Risks Arise Early After Gestational Diabetes

Gestational diabetes is linked to an increased risk for type 2 diabetes and other cardiometabolic conditions within the first few years postpartum.

Recommended News For You

A new blood test greatly increases the ability to detect cancer.

Routine breast cancer screening can bring better outcomes for patients

Study finds 81% of cancer cures touted by TikTok videos are fake

Early Tislelizumab May Boost PFS in Esophageal Cancer

Radioiodine therapy found to improve relative survival rates of differentiated thyroid cancer patients

BTK Inhibitor Active in Half of Patients With Richter Transformation

Efanesoctocog Alfa Prevented Bleeding in Kids With Severe Hemophilia A

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