7 mars 2023

Published Date: 10 Mar 2023

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Combining GLP-1 and SGLT2 Drugs Produce Some Benefits in T2D

A large real-world study shows lower all-cause mortality and some cardiovascular outcomes with combination therapy; other outcomes lack statistical precision.

Well-Known Cardiac Marker Signals Kidney Decline in Diabetes

B-type natriuretic peptide shows a graded association with decline in kidney function in individuals with diabetes, even at concentrations ≤ 18.4 pg/mL, which are conventionally considered normal.

Do Stabilisation Admissions Support Eating Disorder Care?

More than half of children and young people admitted for medical stabilisation of restrictive eating disorders continue recovery through outpatient care, although many require nutritional support.

Direct Oral Anticoagulants Linked to Fewer Brain Bleeds

The use of direct oral anticoagulants is linked to fewer intracerebral haemorrhage than the use of vitamin K antagonists, without an increase in the incidence of haemorrhage at the population level.

SGLT2 Inhibitors Linked to Lower Gout Medication Need in T2D

SGLT2 inhibitors may reduce gout flares and decrease the need for urate-lowering and acute gout medications in adults with both gout and type 2 diabetes.

AI Mammography Flags Cardiovascular Risk

AI can quantify breast arterial calcifications on routine mammograms and flag women with higher cardiovascular risk, enabling opportunistic heart disease screening.

Todays Updates

Early Tislelizumab May Boost PFS in Esophageal Cancer

For patients with locally advanced esophageal cancer, front-loading immunotherapy with induction chemo and chemoradiotherapy, without maintenance immunotherapy, may improve outcomes.

ctDNA Predicts Relapse in Locally Advanced Cervical Cancer

Posttreatment ctDNA positivity correlates with worse relapse-free survival and earlier recurrence in patients with locally advanced cervical cancer, real-world data show.

GLP-1 RAs May Lower Hysterectomy Risk in Endometrial Cancer

There’s now a hint that GLP-1 receptor agonists might prevent hysterectomies in endometrial intraepithelial neoplasia/early-stage endometrial cancer, but prospective trials are needed to confirm it.

Todays Updates

Early Tislelizumab May Boost PFS in Esophageal Cancer

For patients with locally advanced esophageal cancer, front-loading immunotherapy with induction chemo and chemoradiotherapy, without maintenance immunotherapy, may improve outcomes.

ctDNA Predicts Relapse in Locally Advanced Cervical Cancer

Posttreatment ctDNA positivity correlates with worse relapse-free survival and earlier recurrence in patients with locally advanced cervical cancer, real-world data show.

GLP-1 RAs May Lower Hysterectomy Risk in Endometrial Cancer

There’s now a hint that GLP-1 receptor agonists might prevent hysterectomies in endometrial intraepithelial neoplasia/early-stage endometrial cancer, but prospective trials are needed to confirm it.

Latest News

A large real-world study shows lower all-cause mortality and some cardiovascular outcomes with combination therapy; other outcomes lack statistical precision.

B-type natriuretic peptide shows a graded association with decline in kidney function in individuals with diabetes, even at concentrations ≤ 18.4 pg/mL, which are conventionally considered normal.

More than half of children and young people admitted for medical stabilisation of restrictive eating disorders continue recovery through outpatient care, although many require nutritional support.

The use of direct oral anticoagulants is linked to fewer intracerebral haemorrhage than the use of vitamin K antagonists, without an increase in the incidence of haemorrhage at the population level.

SGLT2 inhibitors may reduce gout flares and decrease the need for urate-lowering and acute gout medications in adults with both gout and type 2 diabetes.

AI can quantify breast arterial calcifications on routine mammograms and flag women with higher cardiovascular risk, enabling opportunistic heart disease screening.

News All Time

Exercise Intensity Over Volume Linked to Lower Disease Risks

Higher intensity of physical activity, regardless of total volume, is linked to significantly lower risks for many cardiovascular and other chronic diseases and death.

Genetic Risk Tied to Postpartum BP Risk, BMI Matters More

First-time mothers with high genetic risk for systolic blood pressure have a higher likelihood of postpartum hypertension, but BMI and hypertensive pregnancy disorders are stronger risk factors.

Apixaban May Cut Stroke Risk but Raise Bleeding in Dialysis

Observational data suggest apixaban leads to fewer thromboembolic events but higher bleeding risk, highlighting the need for individualized decision-making in dialysis patients.

The Case for Muscle Power Over Strength

The ability to move a weight with force may be a better predictor of mortality risk than how much weight you can move overall. A beneficial tweak for exercise Rx?

AI Model Can Help Cut Hospitalizations in Dialysis Patients

AI-driven interventions reduce the odds of hospitalization within 7 days by 8% in patients with end-stage kidney disease receiving hemodialysis, according to a recent study.

Wall Thickness Heterogeneity Improves Cardiomyopathy Detection

Heterogeneity in the thickness of the heart wall, represented by wall thickness standard deviation, can improve the early detection of hypertrophic cardiomyopathy and mutation carriers, a study shows.

Stable Patients May Safely End Beta-Blockers Post-MI

Stable patients who stop taking beta-blockers a year or more after a heart attack fare no worse than those who keep taking them, a study conducted in South Korea finds.

PVR Reduced in Adults With HFpEF, Pulmonary Hypertension

In a phase 2 trial, treatment with sotatercept shows reduced pulmonary vascular resistance and heart outcomes in patients with combined postcapillary and precapillary pulmonary hypertension and HFpEF.

Veterans Often Miss Out on Quadruple Therapy for HFrEF

Most US veterans who have new heart failure with reduced ejection fraction do not receive all four classes of guideline-directed medical therapy, and many die before starting full therapy, a study finds.

Empagliflozin May Boost Exercise Tolerance in T2D

In patients with type 2 diabetes, 6 months of empagliflozin therapy vs sitagliptin therapy is tied to a modest increase in the fat oxidation rate during exercise of low-to-moderate intensity.

Should Your Patient Be on Statins? Maybe the Eyes Can Tell

A trial of an AI algorithm that uses retina images to evaluate the risk for atherosclerotic cardiovascular disease demonstrates a high level of accuracy.

Europe’s DNR Divide: Why CPR Discussions Are So Difficult

How do you speak with a deteriorating, in-hospital patient about resuscitation decisions? Physician confidence and legal frameworks vary, with direct impacts on patients.

Fluid Monitoring Device Can Improve HFpEF Outcomes

By early detection of fluid in the lungs, a device allows early therapy adjustments to reduce all-cause mortality in patients with heart failure with preserved ejection fraction.

Liraglutide Lessens Sleep Apnea in COPD With Obesity

Liraglutide reduced obstructive sleep apnea severity and improved quality of life in patients with overweight or obesity and COPD in a randomized trial.

Australia Bans Use of Genetic Testing Data by Life Insurers

Australia has banned life insurance companies from using genetic testing information to deny or restrict policies.

Can Vitamin D Promote a Healthier Gut in IBD?

Vitamin D supplementation is linked to less disease activity and inflammation in inflammatory bowel disease and may restore healthy interactions between the immune system and the gut.

Recommended News For You

More People Than Previously Believed Have Schizophrenia.

Tafasitamab-Based Combination Boosts PFS in Relapsed/Refractory Follicular Lymphoma

Study finds higher breast cancer rates in areas with more air pollution

New imaging guidelines for head and neck cancers, a step toward practice change

According to research, the mineralization of the bone matrix controls the growth of tumor cells.

Q&A: Researchers discuss identifying potential new protein targets for melanoma therapeutics

Hybrid imaging test combines antibody and radioisotope for early lung cancer detection

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