7 mars 2023

Published Date: 10 Mar 2023

Today's top stories include: Nine-year cap to complete MBBS, elective-based credits offered in NMC letter Students enrolled in...

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Can Nurses Safely Replace Physicians in Some Roles?

An 82-trial Cochrane review finds little difference in mortality, quality of life, or safety when nurses substitute for physicians — but outcomes vary widely by specialty and model.

Dialysis Patients With Diabetes Face High Amputation Burden

Patients undergoing dialysis, especially those with diabetes as the primary renal disease, face a high risk for lower limb amputation and mortality after amputation, a cohort study finds.

Less Weight Regain, More Health Loss after Stopping GLP-1s?

Patients on GLP-1s who stop taking the drugs may maintain 25% of their weight loss at one year, but whether their regained weight is mainly fat or lean mass isn’t clear.

Societies Issue Pharmacologic Obesity Management Guidance

The Obesity Society, Obesity Medicine Association, and the Obesity Action Coalition have published joint guidance incorporating patient input.

Smartwatch Hypertension Alerts Shouldn’t Replace Screening

Receiving an alert increased the probability of undiagnosed hypertension, but absence of an alert did not reliably rule it out and should not replace cuff-based screening.

Can Drug-Eluting Balloons Challenge Stents in STEMI?

Proponents argue drug-eluting balloons avoid permanent implants and may shorten dual antiplatelet therapy, whereas critics warn of vessel dissection and the need for bailout stenting.

Todays Updates

Biomarker Flags 10-Fold Recurrence Risk in Testicular Cancer

MiR-371 isn’t ready for the clinic yet, but it is ready for interventional trials to see if it can refine adjuvant chemotherapy decisions in stage I testicular cancer.

FDA Approves New Drug Combo for RR Multiple Myeloma

Teclistamab plus daratumumab and hyaluronidase-fihj is approved for relapsed or refractory MM after one prior line of therapy, including a proteasome inhibitor and immunomodulatory agent.

Todays Updates

Biomarker Flags 10-Fold Recurrence Risk in Testicular Cancer

MiR-371 isn’t ready for the clinic yet, but it is ready for interventional trials to see if it can refine adjuvant chemotherapy decisions in stage I testicular cancer.

FDA Approves New Drug Combo for RR Multiple Myeloma

Teclistamab plus daratumumab and hyaluronidase-fihj is approved for relapsed or refractory MM after one prior line of therapy, including a proteasome inhibitor and immunomodulatory agent.

Latest News

An 82-trial Cochrane review finds little difference in mortality, quality of life, or safety when nurses substitute for physicians — but outcomes vary widely by specialty and model.

Patients undergoing dialysis, especially those with diabetes as the primary renal disease, face a high risk for lower limb amputation and mortality after amputation, a cohort study finds.

Patients on GLP-1s who stop taking the drugs may maintain 25% of their weight loss at one year, but whether their regained weight is mainly fat or lean mass isn’t clear.

The Obesity Society, Obesity Medicine Association, and the Obesity Action Coalition have published joint guidance incorporating patient input.

Receiving an alert increased the probability of undiagnosed hypertension, but absence of an alert did not reliably rule it out and should not replace cuff-based screening.

Proponents argue drug-eluting balloons avoid permanent implants and may shorten dual antiplatelet therapy, whereas critics warn of vessel dissection and the need for bailout stenting.

News All Time

EMA Rejects Drugs for Rett Syndrome, Schizophrenia

Daybue was turned down for Rett syndrome, and Iloperidone for schizophrenia and bipolar I, with safety and benefit-risk concerns cited in both cases.

Resuscitation’s Ethical Dilemma: Rethink Epinephrine Use

Epinephrine improves ROSC in cardiac arrest but does not increase favorable neurologic recovery, raising ethical and guideline questions for clinicians.

Bariatric Surgery Beats GLP-1s for Heart Protection in T2D

A meta-analysis of 11 studies involving over 19,000 patients with T2D and obesity shows that bariatric surgery provides greater cardiovascular protection and mortality reduction than GLP-1 drugs.

Tenecteplase May Help Stroke Recovery Past 4.5-Hour Window

Some patients with a common type of stroke benefit from a clot-busting drug given between 4.5 and 24 hours after symptoms emerged, according to a new study.

How Leptin Became the Sexiest Thing in Science (Again)

Thirty years after its discovery, scientists are eyeing leptin with renewed interest, for everything from weight loss drug cocktails to novel treatments for rare diseases and anorexia.

Alarming Rise in CVD Deaths Among US Adults With Obesity

Cardiovascular mortality among US adults with obesity tripled from 1999 to 2023, with persistent and widening disparities across certain sociodemographic and geographic groups.

Younger Women Face Increase in Heart Disease Risk

A new AHA scientific statement warns that cardiovascular disease is rising fastest among younger women, with stroke rates in those aged 20-44 years projected to nearly double by 2050.

Bariatric Surgery Boosts Metabolic Health in T1D and Obesity

Metabolic bariatric surgery is linked to significant weight loss, lower insulin requirements, and improvements in glycaemic control in adults with type 1 diabetes and obesity.

Pregnancy Hypertension Timing Tied to Long-term Hypertension

Hypertensive disorders of pregnancy, whether detected before, during, or after childbirth, are linked to an increased risk of developing high blood pressure 2-7 years after delivery.

Do Higher Inflammatory Marker Levels Matter After Stroke?

After stroke, atrial fibrillation is linked to higher inflammation beyond the acute phase; higher high-sensitivity C-reactive protein levels are tied to a risk for major events, not recurrent stroke.

How Nighttime Light Quietly Became a Serious Health Threat

More and more research links nighttime light exposure to negative effects on cardiac, metabolic, cognitive, and mental health. What makes it so harmful?

Q&A: AMA President’s Health Crisis Informs View of US System

Bobby Mukkamala, MD, knew the facts and statistics. But a brain tumor truly opened his eyes.

Low Coronary Plaque Burden May Not Equal Low Risk in Women

Women who present with chest pain or angina may be at greater risk for heart attack, hospitalization, and death than men with the same plaque burden.

Youth With Developmental Disabilities Face Higher Mortality

Youth and young adults with autism spectrum disorder, intellectual disability, or cerebral palsy experience higher mortality than the general population; causes of death vary widely.

Alexei Navalny’s Death: Epibatidine Poisoning Suspected

European labs report epibatidine in samples from Alexei Navalny, suggesting poisoning. No public autopsy data; clinicians stress critical supportive care for such toxins.

AI Assistant Offers Promise for Patients After HFrEF

A virtual assistant powered by AI supervised by a cardiologist can offer guideline-directed medical therapy optimization after hospitalization for heart failure with reduced ejection fraction.

Recommended News For You

Pancreatic Cancer: A Novel CD40 Agonist-Chemo Combo Shows Promise.

New tumor therapy approach reduces costs and side effects while increasing accessibility

Achieves a High Disease Control Rate in Head and Neck BCC with Vismodegib-RT Regimen.

Patients with metastatic breast cancer can predict their response to HER2-targeted therapy using whole-body PET/CT.

Avoiding Neuropathy From Chemo; Predictive Value of Screening EKGs

Frontline EGFR/VEGF Inhibition Slows Advanced EGFR-Positive Lung Cancer

For cancer patients who are not responding to chemotherapy, new genes and natural toxins offer hope.

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