Mar 20 2026 This Week in Cardiology

Published Date: 23 Mar 2026

Listener feedback, the huge CLOSURE-AF trial of LAAC vs best medical therapy, previews of CHAMPION AF, and the controversial ACC/AHA lipid treatment guidelines are the topics John Mandrola, MD, discusses in this week's podcast.

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Latest News

Early Breast Cancer: Time to Act on Molecular Resistance?

In breast cancer, molecular resistance can precede clinical progression, but should it prompt an immediate change in treatment?

Punch Biopsy Techniques Every PCP Should Know

Performing a punch biopsy doesn't have to be daunting. Learn the essential steps every PCP needs to confidently sample, suture, and care for biopsy sites.

Risk Assessment of Thyroid Nodules: A Practical Guide

Most thyroid nodules are benign, but risk stratification matters. Learn how ultrasound, TI-RADS, and postbiopsy tools guide smarter referral decisions.

A PCP’s Guide to Tangential Shave Biopsy

Learn how to perform a tangential shave biopsy with confidence. This step-by-step guide walks PCPs through the essential technique for sampling skin lesions and tumors.

Four Signs You Should Biopsy a Skin Lesion, Not Freeze It

Before you freeze a skin lesion, ask yourself whether you really know what it is. Here are four signs you should biopsy instead of freeze.

BRCA Testing Shifts From Late Data to Urgent Priority

BRCA testing now guides urgent treatment decisions as well as family risk assessment, and Spanish experts highlight its implications for PARP inhibitors, oncofertility, liquid biopsy, and exercise.

Todays Updates

Hyponatremia Risk Varies Among Second-Gen Antipsychotics

Aripiprazole is associated with a lower risk for hyponatremia compared with olanzapine in patients treated with second-generation antipsychotics, a new cohort study shows.

HCT Survival Outcomes Improving in Relapsed Hodgkin Lymphoma

Researchers evaluate changes in post-transplantation outcomes among patients with relapsed or refractory Hodgkin lymphoma from 2010 to 2022.

How Much of a Cancer Drug Is Too Much?

In a recent KFF survey, 43% of US adults said they had skipped their medication in the past year because of cost.

Todays Updates

Hyponatremia Risk Varies Among Second-Gen Antipsychotics

Aripiprazole is associated with a lower risk for hyponatremia compared with olanzapine in patients treated with second-generation antipsychotics, a new cohort study shows.

HCT Survival Outcomes Improving in Relapsed Hodgkin Lymphoma

Researchers evaluate changes in post-transplantation outcomes among patients with relapsed or refractory Hodgkin lymphoma from 2010 to 2022.

How Much of a Cancer Drug Is Too Much?

In a recent KFF survey, 43% of US adults said they had skipped their medication in the past year because of cost.

Latest News

In breast cancer, molecular resistance can precede clinical progression, but should it prompt an immediate change in treatment?

Performing a punch biopsy doesn't have to be daunting. Learn the essential steps every PCP needs to confidently sample, suture, and care for biopsy sites.

Most thyroid nodules are benign, but risk stratification matters. Learn how ultrasound, TI-RADS, and postbiopsy tools guide smarter referral decisions.

Learn how to perform a tangential shave biopsy with confidence. This step-by-step guide walks PCPs through the essential technique for sampling skin lesions and tumors.

Before you freeze a skin lesion, ask yourself whether you really know what it is. Here are four signs you should biopsy instead of freeze.

BRCA testing now guides urgent treatment decisions as well as family risk assessment, and Spanish experts highlight its implications for PARP inhibitors, oncofertility, liquid biopsy, and exercise.

News All Time

Excess and Dysfunctional Fat as a Primary Driver of HFpEF

The role of excess and dysfunctional fat in the genesis of HFpEF is well recognized, likely representing a primary or major upstream contributing cause in the large majority of patients.

Primary or Substance-Induced Psychosis? How to Tell and Treat

Distinguishing substance-induced psychosis from primary psychotic disorders starts with the history. Dr Adjoa Smalls-Mantey reviews the diagnostic clues and treatment approach.

S1 Episode 6: Choosing Therapies for ATTR-CM in 2026

Drs Alexander and Urey walk through stabilizers vs silencers, pivotal trial data, and practical first line choices to help you select the right ATTR CM therapy for each patient.

Melanoma Clues Every PCP Should Know

A mole that stands out from the rest or keeps changing may be a warning sign. See how PCPs can use the ugly duckling sign and other clues in melanoma assessment.

Woman Develops Autoimmune/Inflammatory Syndrome After Filler

A woman develops autoimmune/inflammatory syndrome induced by adjuvants after hyaluronic acid filler and hyaluronidase exposure, with biopsy-confirmed acquired cutis laxa.

S1 Episode 3: Incidental Fatty Liver on Imaging: What Should You Do Next?

When fatty liver appears incidentally on imaging, "just lose weight" isn't enough. Dr Brandman explains how to use FIB-4, FibroScan, and ELF to triage who needs referral and who doesn't.

When to Worry About Pediatric Joint Pain

Which pediatric musculoskeletal complaints need an urgent workup? Dr Basco shares a systematic approach to identifying clinical red flags and serious pathology.

Fast Five Quiz: Presentation and Diagnosis of Psoriasis

How much do you know about the presentation and diagnosis of psoriasis? Test your knowledge with this quick quiz.

Skin Biopsy Essentials for Primary Care

Selecting the right biopsy technique is key to accurate diagnosis. Review practical guidance on shave and punch biopsies in primary care.

Pott’s Puffy Tumor in Teen Leads to Bilateral Blindness

A teen with Pott’s puffy tumor develops irreversible bilateral blindness after delayed diagnosis and intracranial complications, highlighting the importance of its early recognition.

Anti-Amyloids and Meaningful Change

Preventive neurologists Richard Isaacson and Jennifer Buczyner discuss the role of anti-amyloid drugs in patients with Alzheimer’s or mild cognitive impairment.

Can One Blood Test Detect 50 Cancers Early?

The latest evidence suggests multicancer early detection could expand screening beyond mammography and colonoscopy, yet key questions on outcomes and false positives remain.

A 5-Week-Old Male Presents With Blisters on His Right Leg

Examination revealed pink inflammatory papules and vesicles with areas of brown scale in a linear distribution extending from just above the right medial malleolus to the right inguinal crease.

Fever and Rash Reveal Japanese Spotted Fever in Woman

Recognizing fever, rash, and an eschar after tick exposure can support early diagnosis and timely antibiotic treatment, reducing the risk for severe complications.

Lost in Translation: Cancer Care's Coordination Problem

No shared records. No standard handoff. No common language. Three physicians break down why cancer care coordination keeps failing.

S3 Episode 5: The Future of Endometrial Cancer Pathology

Drs Ursula A. Matulonis and Marisa R. Nucci discuss the future of AI and pathology and how genetics and genomics play a role in the diagnosis of endometrial cancer.

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Year in Review: Multiple Myeloma

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In KRAS-mutated non-small cell lung cancer, glecirasib exhibits promising efficacy.

New Zealand and Australian breast cancer rates among the highest in the world, global study finds

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