Mar 27 2026 This Week in Cardiology

Published Date: 28 Mar 2026

Early aortic valve replacement in aortic stenosis, left atrial appendage occlusion in JAMA Cardiology, and a big preview of the upcoming American College of Cardiology meeting are the topics John Mandrola, MD, discusses in this week’s podcast.

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A French Doctor’s Life in Greenland

A French gynecologist recounts 11 years as Greenland’s lone hospital doctor, where polar nights, isolation, and Inuit hospitality shaped her extraordinary life.

The Puzzling Cancer Mutation That May Lower Alzheimer’s Risk

Two groups studied the same cancer mutations in the blood. They agreed on many aspects, including the mechanism at work. But their answers were radically different.

Oral Antihistamines Ease Pediatric Allergic Rhinitis

Oral antihistamines appear to be effective in reducing nasal symptoms and improving quality of life compared with placebo in children with allergic rhinitis, a network meta-analysis finds.

Immunosuppressive Rxs in Children: Infection Risk Screening

The evolution in the types of immunosuppressive therapies used in children and the frequency with which they are prescribed has increased the importance of pretreatment screening for infection risk.

Kidney Transplant Recipients to Get Double-Matched Blood

The NHS is rolling out blood matched for red and white cells to kidney transplant patients, potentially averting 100 rejections a year.

Newborns' Low Sodium Tied to Later Brain Disorders or Death

Hyponatraemia during the first 72 hours of life is linked to later neurodevelopmental disorders or death in infants with perinatal asphyxia.

Todays Updates

Hyponatremia Risk Varies Among Second-Gen Antipsychotics

Aripiprazole is associated with a lower risk for hyponatremia compared with olanzapine in patients treated with second-generation antipsychotics, a new cohort study shows.

HCT Survival Outcomes Improving in Relapsed Hodgkin Lymphoma

Researchers evaluate changes in post-transplantation outcomes among patients with relapsed or refractory Hodgkin lymphoma from 2010 to 2022.

How Much of a Cancer Drug Is Too Much?

In a recent KFF survey, 43% of US adults said they had skipped their medication in the past year because of cost.

Todays Updates

Hyponatremia Risk Varies Among Second-Gen Antipsychotics

Aripiprazole is associated with a lower risk for hyponatremia compared with olanzapine in patients treated with second-generation antipsychotics, a new cohort study shows.

HCT Survival Outcomes Improving in Relapsed Hodgkin Lymphoma

Researchers evaluate changes in post-transplantation outcomes among patients with relapsed or refractory Hodgkin lymphoma from 2010 to 2022.

How Much of a Cancer Drug Is Too Much?

In a recent KFF survey, 43% of US adults said they had skipped their medication in the past year because of cost.

Latest News

A French gynecologist recounts 11 years as Greenland’s lone hospital doctor, where polar nights, isolation, and Inuit hospitality shaped her extraordinary life.

Two groups studied the same cancer mutations in the blood. They agreed on many aspects, including the mechanism at work. But their answers were radically different.

Oral antihistamines appear to be effective in reducing nasal symptoms and improving quality of life compared with placebo in children with allergic rhinitis, a network meta-analysis finds.

The evolution in the types of immunosuppressive therapies used in children and the frequency with which they are prescribed has increased the importance of pretreatment screening for infection risk.

The NHS is rolling out blood matched for red and white cells to kidney transplant patients, potentially averting 100 rejections a year.

Hyponatraemia during the first 72 hours of life is linked to later neurodevelopmental disorders or death in infants with perinatal asphyxia.

News All Time

Gram-Negative Bacteria Lead Pediatric Cancer BSIs

Gram-negative bacteria account for nearly 70% of bloodstream infections in pediatric oncology patients, with nonsusceptibility rates of some organisms to antibiotics increasing.

Does CKD Severity Predict Adverse ICU Outcomes?

Among patients in the ICU, the presence and severity of chronic kidney disease are tied to a higher risk for mortality; among those who receive maintenance dialysis, the risk is comparatively lower.

Argenx Drug Vyvgart Meets Goal in Autoimmune Myositis Study

Belgian-Dutch immunology company argenx said on Monday its autoimmune drug Vyvgart met the primary endpoint in a late-stage study in autoimmune myositis, ⁠potentially...

Medical Therapy Reduces Nasal Discharge in CRS

Medical therapy significantly reduces nasal discharge symptoms in chronic rhinosinusitis, with benefits observed in both patients with nasal polyps and those without.

Antioxidants in Vitiligo: Experts Support Select Ingredients

Experts say some antioxidants can improve vitiligo with or without phototherapy, but ingredients backed by evidence remain limited.

Cannabis Use May Increase Fall Risk in Adults With HIV

Among adults living with HIV, cannabis use is associated with an increased risk for falls — but the link weakens after accounting for other substance use and medications.

VNS for RA a Year After Approval: Where Do Things Stand?

A year after approval of the first VNS device for rheumatoid arthritis, many patients are interested and providers in eight states are able to offer the device, but insurers are hesitating.

SLE Linked to Increased Risk for Venous Thromboembolism

Systemic lupus erythematosus is associated with an increased risk for venous thromboembolism, with the highest risk occurring in the first year after diagnosis.

Dermatologists Highlight Cutaneous Signs of Hantavirus

“Hantavirus dermatology is fundamentally about pattern recognition rather than recognition of a specific rash,” one dermatologist points out.

Aug 14 2026 This Week in Cardiology

Listener feedback, the ZEUS trial fails, a fascinating statin trial, more on GLP-1 drugs, and radiation safety in the EP lab are the topics John Mandrola, MD, discusses in this week’s podcast.

RSV Maternal Vaccine Halves Baby Intensive Care Admissions

UKHSA data show a 50% drop in newborn ICU admissions since the RSV maternal vaccine programme took full effect, though officials say low uptake still leaves many babies exposed.

New Evidence Links Atopic Dermatitis to Herpes Zoster

A study of more than 13 million people in the UK finds an association between atopic dermatitis and herpes zoster, including after adjusting for comorbidities, treatments, and other factors.

Antiphospholipid Antibodies Linked to Pregnancy Risks in SLE

Certain antiphospholipid antibody profiles are associated with increased odds of adverse pregnancy outcomes in women with systemic lupus erythematosus.

Metabolic, Autoimmune Links Seen in Sclerosing Mesenteritis

Patients with symptomatic sclerosing mesenteritis often present with abdominal pain and have concurrent autoimmune, malignant, or metabolic disorders.

How Immigration Raids Emptied a Local Pediatric Clinic

Fear of immigration operations keeps vulnerable families away from the doctor, driving a sharp rise in missed appointments and leaving critical childhood care on hold.

This Is What mRNA Vaccines May Actually Do in the Body

Muscle cells, not just dendritic cells, help mRNA vaccines work, with big implications for vaccine and therapy design.

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Wide Variation Seen in Lung Screening False-Positive Rates

'Ray of hope': New developments in the fight against various cancers.

Breast Cancer Genetic Testing Need in Black Women Identified

Chronic stress and obesity work together to accelerate pancreatic cancer development and growth, study finds

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