Seladelpar Given Go-Ahead by NICE for PBC Treatment

Adding Dexamethasone to ONB Offers No Benefit in Headache

Adding dexamethasone to occipital nerve block offered no additional reduction in headache days compared to ONB alone, a new randomized controlled trial shows.

ctDNA Can Predict Relapse, but Should Oncologists Act On It?

As ctDNA moves into clinical practice, oncologists across specialties are grappling with whether and how to use the results to guide treatment decisions.

Patient-Reported QoL Offers Prognostic Information in AML

The pretreatment evaluation of patient-reported, health-related quality of life provides valuable prognostic information on overall survival beyond genetic and clinical data.

IBS and Physical Activity: What’s the Link?

Higher levels of Fitbit-recorded physical activity are linked to lower odds of irritable bowel syndrome, whereas greater sedentary time is linked to higher odds of the condition.

The Obesity Paradox: High in Calories, Low in Nutrients

Beyond Laxatives: Emerging Ways to Manage Constipation

In this Medscape podcast, Dr Benjamin Levy interviews Dr Darren Brenner about modern constipation management, including pelvic floor dysfunction, motility testing, and nonpharmacologic therapies.

New Data Support Medication Switch in Select MS Patients

For patients experiencing increased rates of infection or adverse events on anti-CD20 therapy, switching to a less immunosuppressive option may be a safe option, data show.

Frontline Serplulimab Extends Survival in SCLC

Four-year follow-up from the ASTRUM-005 trial shows durable survival benefits with first-line serplulimab plus chemotherapy in extensive-stage SCLC.

Scotland Backs Bispecific Antibody for Refractory Myeloma

The SMC accepted talquetamab for relapsed and refractory multiple myeloma, offering eligible patients in Scotland a new option after multiple prior therapies.

Primary Care Anti-Dementia Med Prescribing Shows Disparities

Prescribing rates for anti-dementia medications in England are lower than expected, with notable disparities in prescribing based on patient-level characteristics.

Mailed DNA Test Boosts CRC Screening in Community Centers

A mailed FIT-DNA outreach program may be more effective than a mailed FIT kit with text reminders at increasing colorectal cancer screening rates in community health centers.

Doctors Face Tough Conversations as Patient Debt Grows

Physicians often feel moral harm when faced with their patients’ inability to pay for care.

Apple Watch App Detects Seizures With Fewer False Alarms

An app tied to the Apple Watch detects 46 of 47 tonic-clonic seizures with a false-alarm rate lower than that reported for other seizure detection devices.

How Common Are Bacterial Infections in Infants With Fever?

About 1 out of 100 well-appearing infants aged 60-90 days with fever have an invasive bacterial infection, according to a meta-analysis.

Hantavirus Outbreak Highlights the Importance of One Health

The recent hantavirus outbreak underscores how urbanization, deforestation, and rodent reservoirs can converge to shape zoonotic risk.

Alcohol Intake Tied to Increased Colorectal Cancer Risk

Dr Maurie Markman discusses a PLCO trial analysis highlighting the stark association between consistent heavy drinking and increased colorectal cancer risk.