Identifying pathogenic proteins leads to potential new treatments for diseases such as diabetes.

Published Date: 02 Mar 2023

New research has identified hundreds of proteins that can lead to the development of metabolic diseases, such as type 2 diabetes mellitus, and therefore have treatment potential.

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Tirzepatide Yields Early Weight Loss, Later Plateau

Modeling finds marked early weight loss with tirzepatide that later plateaus as appetite returns and energy expenditure decreases, and discontinuation of the drug is linked to partial weight regain.

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Stigma Negatively Affects Postbariatric Outcomes

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Can Fasting Around Chemo Improve Ovarian Cancer Outcomes?

Women with ovarian cancer who fast shortly before and after chemotherapy have lower insulin levels, stronger tumor responses, and longer progression-free survival in a small randomized trial.

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Can Fasting Around Chemo Improve Ovarian Cancer Outcomes?

Women with ovarian cancer who fast shortly before and after chemotherapy have lower insulin levels, stronger tumor responses, and longer progression-free survival in a small randomized trial.

Latest News

Semaglutide and tirzepatide use is rising among patients with rheumatic and musculoskeletal diseases and is linked to meaningful 1-year weight loss, especially in tirzepatide users.

The Fracture Risk Assessment Tool predictions suggest patients who don’t meet guideline criteria for parathyroidectomy may nevertheless benefit from the surgery.

Specific serum acylcarnitine levels are linked to faster kidney function decline in type 2 diabetes and can help improve the prediction of patients at highest risk for rapid decline.

Modeling finds marked early weight loss with tirzepatide that later plateaus as appetite returns and energy expenditure decreases, and discontinuation of the drug is linked to partial weight regain.

Emerging evidence suggests some sugar substitutes may affect metabolism, gut microbiome, and cardiovascular health more than previously recognized.

Weight bias, stigma, and discrimination are linked to poorer mental health and weight outcomes after bariatric surgery, although the long-term physical effects remain understudied.

News All Time

Private-Sector Healthcare Rise May Affect Canadians’ Trust

As the number of privately funded providers and clinics in Canada increases, it may set up a two-tier system where those who can afford to pay out of pocket may have faster access to care.

Hypothyroidism Drug May Cause Psychiatric Morbidity

The addition of liothyronine to levothyroxine treatment is associated with a higher risk for psychiatric morbidity in patients with autoimmune hypothyroidism.

Maternal Overnutrition Linked to Obesity in Adult Offspring

Maternal overnutrition is associated with a higher likelihood of obesity in adult offspring, with effects persisting into adulthood and being more pronounced in women.

French Regulators Fine Novo, Lilly Over GLP-1 Campaigns

French regulators say obesity awareness campaigns may blur the line between public education and the promotion of prescription weight-loss drugs.

EASO Update Gives Clearer Roles for Tirzepatide, Semaglutide

EASO’s ‘living’ algorithm has been updated with the latest evidence, strengthening tirzepatide’s position for weight loss and semaglutide’s role in liver fibrosis improvement.

Is Persistent Hunger After Weight Loss Behind Weight Regain?

People who regain lost weight may be biologically driven to do so via hyperphagia, an insatiable hunger and an intense preoccupation with food.

Acute Kidney Injury Sets Kids Up for Chronic Kidney Disease

A meta-analysis finds increased long-term odds of chronic kidney disease and death in children who survive acute kidney injury.

Cotrimoxazole Tied to More AEs in Older Men With UTIs

The use of cotrimoxazole is linked to about twice the risk of developing adverse events compared with the use of fluoroquinolones among older men with UTIs.

GLP-1 RAs May Independently Boost Testosterone Levels

Increases in testosterone were realized in a large cohort regardless of patient age or BMI at baseline and could not be explained just by weight loss.

New Dosing Option Okayed for X-Linked Hypophosphatemia Drug

The FDA has approved an option to increase the dose and frequency of burosumab-twza for adults whose serum phosphorus remains below normal.

BioMarin's Genetic Disease Therapy Shows Mixed Results in Late-stage Study

BioMarin Pharmaceutical said on Monday its experimental treatment for a rare genetic condition met ⁠one of the two main goals in a late-stage study.

Many Parents on Obesity Meds Discuss Treatment With Kids

Parents often discuss using obesity medications and related weight or behavior changes with their children.

Menopause Symptoms Worse in Women With Abdominal Obesity

Women with abdominal obesity report a higher burden of certain menopausal symptoms and exhibit a distinct pattern of symptom interrelationships relative to women without abdominal obesity.

Restarting GLP-1s After Stopping: How to Counsel Patients

Many patients taking GLP-1 RAs for weight loss discontinue within the first year. How can clinicians support long-term success with these drugs?

Pesticides May Help Explain Rising Early-Onset CRC Rates

A study linked a common herbicide to rising early-onset colorectal cancer, using DNA methylation to trace lifelong exposures rather than relying on patient recall.

Can Lower-Dose Tirzepatide Keep Weight Off?

New trial data suggest some patients may maintain meaningful weight loss after stepping down from the maximum dose of tirzepatide.

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