Is Alzheimer's disease, relentless and slow, a better target for clinical trials?

Published Date: 16 Feb 2023

According to a report by the Alzheimer's Association task force, it's time to reframe what "clinically meaningful" means and change expectations about clinical trials.

Read Full News

Latest News

Migration Medicine Exposes Gaps in Spain

Spain’s repeated migration surges expose gaps in medical training, disaster triage, and medico-legal documentation that clinicians say should no longer be improvised.

How Proposed OMB Funding Restrictions May Reshape Research

OMB has proposed changes affecting federally-funded science that threaten to undermine the integrity of federally-supported research regarding military populations.

There Are Options for Patients at the Highest GLP-1 Dose

Increased focus on diet and exercise or a change in prescriptions among the choices.

Sleep and Obesity Are Intertwined. Do Naps Help or Hurt?

Sleep and Obesity Are Intertwined. Do Naps Help or Hurt? Napping is normal and, in some very specific cases, can be helpful. But length and timing matters.

Letter-Matching Test Favored for Vision Screening in Kids

A vision test that requires young children to match letters may screen better for reduced vision than a test requiring them to indicate the orientation of a letter.

AI May Improve Detection of MASLD on CT Scans

An AI tool reveals a substantial gap in the reporting of incidental hepatic steatosis on noncontrast CT scans and could flag cases that would otherwise go undiagnosed.

Todays Updates

Can 80 Gy Radiation Boost Survival in Prostate Cancer?

A modest increase in radiation dose improves progression-free survival over 10 years among men with high-risk prostate cancer — but the overall survival benefits found in a French trial are uncertain.

Todays Updates

Can 80 Gy Radiation Boost Survival in Prostate Cancer?

A modest increase in radiation dose improves progression-free survival over 10 years among men with high-risk prostate cancer — but the overall survival benefits found in a French trial are uncertain.

Latest News

Spain’s repeated migration surges expose gaps in medical training, disaster triage, and medico-legal documentation that clinicians say should no longer be improvised.

OMB has proposed changes affecting federally-funded science that threaten to undermine the integrity of federally-supported research regarding military populations.

Increased focus on diet and exercise or a change in prescriptions among the choices.

Sleep and Obesity Are Intertwined. Do Naps Help or Hurt? Napping is normal and, in some very specific cases, can be helpful. But length and timing matters.

A vision test that requires young children to match letters may screen better for reduced vision than a test requiring them to indicate the orientation of a letter.

An AI tool reveals a substantial gap in the reporting of incidental hepatic steatosis on noncontrast CT scans and could flag cases that would otherwise go undiagnosed.

News All Time

GCA Patients Stay on Steroids Beyond 48 Months

Despite rheumatologists aiming to discontinue glucocorticoids by 24 months in giant cell arteritis, three quarters of patients continue to receive steroids at 48 months or longer.

Sunscreen Myths: How Evidence Morphed Into Skepticism

Arturo Loaiza-Bonilla, MD, MSEd, explores how confusing and incomplete information on sunscreen safety can lead to misinterpretation and misinformation.

How to Mange Benign Prostatic Hypertrophy in Primary Care

Dr Neil Skolnik breaks down the American Urological Association guideline for the management of benign prostatic hypertrophy.

For Everyday Shoulder Pain, Less Treatment Is Often More

Most patients with a nontraumatic sore shoulder in primary care can be managed with watchful waiting and symptom relief.

Hormonal Contraception Not Linked to Flare Risk in UC

Exposure to hormonal contraception is not linked to an increased risk for recurrent flares or cumulative systemic inflammatory burden in female individuals with ulcerative colitis.

Are Pediatricians Following Newborn Jaundice Guidelines?

The American Academy of Pediatrics changed its guidelines in 2022, but a new study suggests pediatricians may not be consistently applying the updated guidance.

Regular Physical Exercise Tied to Lower Mental Disorder Risk

A prospective study shows that lower levels of physical exercise are consistently associated with a higher risk for common mental disorders in students pursuing higher education.

Does Vitamin B3 Benefit Patients With Raynaud Phenomenon?

Vitamin B3 supplementation improves nailfold capillary patterns in patients with Raynaud phenomenon, with those with primary Raynaud phenomenon experiencing improvements in quality of life.

Excess Gut Sulfide Tied to Distinct Gene Expression Changes

Sulfide overproduction in the gut can alter small bowel gene expression more than bacterial or methanogen overgrowth does, affecting mitochondrial function, redox balance, and immune signaling.

Early Screening Linked to Better Outcomes in RA

Patients referred via a specialized screening clinic that expedites rheumatoid arthritis diagnosis have lower functional disability than those referred via standard referral pathways.

Gutmaxxing: Online Trend, Real-World GI Implications

Western Men Still Dominate Journal Editorial Boards

Editorial boards of major scientific journals are still dominated by Western men, according to a large analysis that also found sharp gaps in women’s representation.

Medication Beliefs Tied to Adherence in Sjögren

In newly diagnosed primary Sjögren disease, low medication adherence was common and linked to how patients weighed treatment necessity against concerns — not to disease severity or symptom burden.

Eating Disorder Genetics Go Beyond BMI

Nearly 90% of the genetic variation associated with anorexia nervosa and binge eating was not explained by BMI, pointing to distinct genetic influences on the two conditions.

Pneumonia Gaps Persist After PCV13 Rollout

Childhood PCV13 vaccination reduces adult pneumonia hospitalizations across all age groups, yet Black adults, those with chronic conditions, and lower-income households still face higher disease rates.