Is Alzheimer's disease, relentless and slow, a better target for clinical trials?

Published Date: 16 Feb 2023

According to a report by the Alzheimer's Association task force, it's time to reframe what "clinically meaningful" means and change expectations about clinical trials.

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Distinct Risk Factor Profiles Tied to Endometriosis Subtypes

Various factors such as menstrual history, pain conditions, and immune disorders are distinctly tied to endometriosis lesion types — superficial lesions, ovarian cysts, and deep lesions.

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FDA Approves Camizestrant for ESR1-Mutated Breast Cancer

The accelerated approval enables an endocrine therapy switch when the ESR1 resistance mutation is detected, rather than waiting for evidence of disease progression.

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FDA Approves Camizestrant for ESR1-Mutated Breast Cancer

The accelerated approval enables an endocrine therapy switch when the ESR1 resistance mutation is detected, rather than waiting for evidence of disease progression.

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A digital pillbox with medication reminders and adherence feedback improves viral suppression in young people with HIV over 6 months, a trial finds.

Adjunctive serial IV ketamine infusions significantly reduced depressive symptoms in TRBD, with no cases of mania, hypomania, or psychosis observed in the randomized trial.

In patients who face difficulty seeing in low light, a once-nightly eye drop significantly improves night vision and reduces glare, halos, and starbursts, a phase 3 trial shows.

Researchers conduct a study of about 4000 women with pathogenic variants in at least one of 13 breast cancer susceptibility genes to see their utilization of cancer risk-reducing procedures.
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Establishing a CWO at a VAMC to Improve Clinician Well-Being

A Chief Well-Being Officer can improve organizational health and clinician quality of life, and multiple VHA facilities have developed the position at their institutions.
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Serious Neutropenia in Clozapine Use: Rare, Occurs Early

Serious neutropenia requiring clozapine cessation is rare, occurs within the first 15 weeks of treatment, and is predicted strongly by older age and a low WBC count.
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Belgian Physician Hans Kluge Enters Race to Lead WHO

Belgium has put Hans Kluge forward as the WHO’s top post, setting up a leadership contest that will shape global health priorities after Tedros’s final term ends in 2027.

Frailty Score Can Predict Mortality in Dialysis Patients

A simple bedside frailty rating by nurses can help predict mortality among patients undergoing dialysis, supporting its practical role as a complementary tool for risk assessment in routine care.

Survey Finds Patients Withhold Symptoms

Women and younger adults are more likely to hold back during medical visits, according to a German survey of 1791 adults.
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FDA Psychiatry Digest: August 2026

A monthly snapshot of FDA activity involving therapies used in the prevention, diagnosis, and treatment of psychiatric conditions.
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Depression May Mask Early Cognitive Decline

Depression and early dementia can look alike in primary care, and experts say longitudinal cognitive monitoring is key to telling them apart.

Sharp Rise in Children Attending A&E in Mental Health Crisis

New analysis reveals a steep rise in children attending A&E in England with mental health concerns.

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