Study identifies a surprising new treatment target for chronic limb-threatening ischemia

Published Date: 13 Sep 2025

What causes poor outcomes in patients with advanced peripheral artery disease who develop a complication called chronic limb-threatening ischemia (CLTI), which has a high risk of limb amputation due to the restriction of ...

Read Full News

Latest News

Women Show Longer Door-to-Needle Time for Stroke Than Men

Women with acute ischaemic stroke experience a longer door-to-needle time in the emergency department, despite both having similar access to treatments.

Experts Debate Weight-Loss Controversies

Microdosing, drugs vs surgery, hormone replacement therapy to induce weight loss, and confusing nomenclature for loss of muscle function were among the hot topics at Obesity Medicine 2026.

Dual Cholesterol Measures May Improve Heart Risk Prediction

Non-high-density lipoprotein cholesterol and apolipoprotein B levels are linked to the risk for atherosclerotic cardiovascular disease, and assessing both markers may improve risk prediction.

Atrial-Fixation TMVR Appears Feasible, Durable at 1 Year

Early feasibility study results are promising for AltaValve, which is designed with a novel atrial fixation system to minimize complications linked to subvalvular fixation.

The Bare Minimum You Need to Do to Add a Year to Your Life

Very small changes across sleeping, eating, and exercise can lead to dramatic gains in lifespan and healthspan.

Is Rapid Weight Loss More Effective Than Gradual Loss?

Rapid weight loss delivered in a structured program yields better outcomes than gradual weight loss, but other factors also need to be considered.

Todays Updates

NP-Led Outreach Ups Cancer Screening in Rural Women Veterans

A nurse practitioner-led outreach program improves the rates of breast and cervical cancer screening among women veterans in rural areas, a retrospective study shows.

Less Mental Decline With Darolutamide vs Enzalutamide in PC

Over half of patients in a randomized trial switch from enzalutamide to darolutamide because of cognitive issues; no one switches in the opposite direction.

Todays Updates

NP-Led Outreach Ups Cancer Screening in Rural Women Veterans

A nurse practitioner-led outreach program improves the rates of breast and cervical cancer screening among women veterans in rural areas, a retrospective study shows.

Less Mental Decline With Darolutamide vs Enzalutamide in PC

Over half of patients in a randomized trial switch from enzalutamide to darolutamide because of cognitive issues; no one switches in the opposite direction.

Latest News

Women with acute ischaemic stroke experience a longer door-to-needle time in the emergency department, despite both having similar access to treatments.

Microdosing, drugs vs surgery, hormone replacement therapy to induce weight loss, and confusing nomenclature for loss of muscle function were among the hot topics at Obesity Medicine 2026.

Non-high-density lipoprotein cholesterol and apolipoprotein B levels are linked to the risk for atherosclerotic cardiovascular disease, and assessing both markers may improve risk prediction.

Early feasibility study results are promising for AltaValve, which is designed with a novel atrial fixation system to minimize complications linked to subvalvular fixation.

Very small changes across sleeping, eating, and exercise can lead to dramatic gains in lifespan and healthspan.

Rapid weight loss delivered in a structured program yields better outcomes than gradual weight loss, but other factors also need to be considered.

News All Time

SSRI vs NDRI: Which Is Better for Post-Stroke Depression?

Bupropion is linked to lower suicidal ideation risk but higher odds of demoralization and apathy vs fluoxetine in post-stroke depression, new research shows.

Time in Target Range Metric May Aid in CKD Management

The urine albumin/creatinine ratio time in target range predicts cardiovascular outcomes in people with and without chronic kidney disease.

TADV Saves Limbs in No-Option CLTI Patients

More than 80% of no-option chronic limb-threatening ischemia patients avoided amputation for 6 months after the procedure while enjoying improved wound healing and reduced pain.

Underground Hospitals: Is Combat Medicine Entering a New Era?

Ukrainian clinicians increasingly rely on protected underground facilities as drone threats complicate evacuation and strain traditional battlefield treatment models.

France Focuses on Drugs That Raise Fall Risk in Older Adults

Long-term benzodiazepines and anticholinergics drive falls in seniors; prioritize nonpharmacologic care and deprescribing to cut injuries and hospitalizations.

Uraemic Marker Predicts Mortality After Kidney Transplant

Plasma levels of symmetric dimethylarginine are independently associated with an increased risk for mortality in adult kidney transplant recipients, a prospective study finds.

GLP-1 Drugs Tied to Cardiovascular Benefits in T1D

Adults with T1D who receive GLP-1-based therapy may have a lower risk for adverse cardiovascular outcomes and no significant increase in diabetic ketoacidosis compared with those who do not.

Transient Neurologic Symptoms: What Clinicians Miss

Speakers warn that transient neurologic events may conceal high-risk vascular disease, seizures, or amnestic syndromes requiring rapid evaluation.

SGLT2 Inhibitors Show Similar Cardiorenal Benefits

Empagliflozin and dapagliflozin show similar effectiveness in preventing cardiorenal outcomes among patients with type 2 diabetes without prior cardiovascular or renal disease.

Orforglipron Maintains Weight Loss After Injectables

The study adds evidence that obesity treatment benefits depend on continued therapy, even when the delivery method changes.

Date Sweetened Foods May Create a Misleading Health Halo

Products sweetened with dates may appear healthier than table sugar, even though concentrated fructose exposure remains a concern.

Telerehabilitation May Support Stroke Recovery at Home

Remote rehabilitation programs improve mobility, balance, and quality of life after stroke, with added benefits in adherence and patient satisfaction.

AI-Powered ECG Shown to Spot Heart Failure

Screening for heart failure with an AI-ECG algorithm could be particularly useful in places with limited access to more advanced diagnostics.

Weather Extremes, Pollution May Raise Major CV Event Risk

A geography-based study in Poland found airborne pollutants can compound the cardiovascular risks of heatwaves and cold snaps, with the latter actually being more hazardous.

SCORE2, Health Dialogues for Risk Factors in Mental Illness

Patients with mental illness seeking primary care show an elevated cardiovascular risk as per SCORE2, and targeted health dialogues identify additional modifiable cardiovascular risk factors.

Electric Scooter-Related Injuries Strain Urban Trauma Units

Emergency departments in Rome and New York reported increasing fractures and head injuries linked to electric scooters and e-bikes, with helmet use remaining low.

Recommended News For You

What is a "cancer vaccine" and is it the same as a COVID vaccine?

Trial Questions Role of Dual Immunotherapy in First-Line NSCLC

A new theranostic drug targets different cancer types.

Congress Ditched Fix to Medicare Doc Pay Cut in Skinny Budget Bill

Frontline EGFR/VEGF Inhibition Slows Advanced EGFR-Positive Lung Cancer

Alkem introduces cetuximab under the trade name Cetuxa in India.

For the treatment of paroxysmal nocturnal hemoglobinuria, the FDA has approved an oral factor B inhibitor.

Recommended Articles For You

Nipple-Sparing Mastectomy: Oncologic Safety and Patient Selection Review 

The Digital Biopsy: How Artificial Intelligence is Redefining Cancer Pathology? 

The Immunotherapeutic and Targeted Revolution in Melanoma Management – A 2025 Perspective 

Beyond the Standard: Personalized Cancer Vaccines and the Dawn of a New Era in Pediatric Oncology 

Whats more on Hidoc Dr.

Medical Updates
KOL Videos
Surveys
Events

Daily news to keep you up to date

Gain valuable insights with our in-depth KOL Video discussions

Participate and win cash vouchers

Get updates on the latest events happening around the world
Featured News
Featured Articles
Featured Events
Featured KOL Videos

1.

More Positive Survival Data in Lung Cancer With Perioperative Therapy

2.

Upfront TKI for Bone-Predominant RCC Tops Single-Agent Immunotherapy

3.

Study finds 10% of pediatric blood cancers may stem from medical imaging radiation

4.

For the creation of cutting-edge targeted radionuclide therapies in oncology, Bayer and Bicycle Therapeutics work together.

5.

Pre-operative evaluation of ovarian cancer patients using DWI-MRI is helpful.

1.

Case Study: Artificial Intelligence in Early Cancer Detection

2.

Understanding Acute Intermittent Porphyria: Symptoms, Diagnosis and Treatment

3.

What is Mullerian and How Does it Affect Your Health

4.

AI in Cancer Care: Transforming Research & Treatment with Deep Learning Technologies

5.

Is p53 the Missing Puzzle Piece? Exploring Its Polymorphisms in Cervical Cancer Risk

1.

International Lung Cancer Congress®

2.

Genito-Urinary Oncology Summit 2026

3.

Future NRG Oncology Meeting

4.

ISMB 2026 (Intelligent Systems for Molecular Biology)

5.

Annual International Congress on the Future of Breast Cancer East

1.

Should We Use DARA Up Front As First-Line Therapy in MM?

2.

Molecular Contrast: EGFR Axon 19 vs. Exon 21 Mutations - Part IV

3.

Management of 1st line ALK+ mNSCLC (CROWN TRIAL Update)

4.

A Continuation to The Evolving Landscape of First-Line Treatment for Urothelial Carcinoma

5.

A Comprehensive Guide to First Line Management of ALK Positive Lung Cancer - Part II

Fastest Growing Medical Platform for Doctors

Address :
Hidoc Dr. Inc. | Delaware C Corp | 1309 Coffeen Ave. Suite 1200, Sheridan WY, 82801

Phone :
+1-415-463-3094

Email :
anishagadia@hidoc.co

Quick Links

Drug DatabaseDrug InteractionDiseases Database
KOL VideosKnowledge HubQuizzes
Medical UpdatesEventsAbout Us

© Copyright 2026 Hidoc Dr. Inc.

Terms & Conditions - LLP | Inc. | Privacy Policy - LLP | Inc. | Account Deactivation
Home
Profile
Login
bot