Should we stop taking thiazides to prevent kidney stones?

Published Date: 08 Mar 2023

"Thiazide is the standard treatment for calcium stones, so this [new research] has the potential to upset the basket," one observer said.

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Obesity Subtypes Predict Poor Physical Function in Knee OA

Obesity and low muscle mass and/or cardiometabolic comorbidities impede physical functioning more than obesity alone in individuals with or at risk for knee osteoarthritis.

Promising Revolution Medicines Pancreatic Cancer Drug Has High Rate Of Mostly Manageable Side Effects

An experimental drug from Revolution Medicines that nearly doubled survival time for patients with advanced pancreas cancer in clinical trials comes with a high rate of...

Primary Care Slow to Adopt Alzheimer’s Blood Tests

Primary care clinicians with higher diagnostic confidence are adopting emerging blood-based Alzheimer’s disease tests, raising questions about training, access, and appropriate use.

Stress, BMI Linked to Earlier Puberty in Girls

Higher levels of non-estrogen hormones, along with stress and elevated BMI, are linked to earlier breast development in girls.

Bariatric Surgery Linked to Higher Nutrient Deficiency Risk

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T-DXd Reduces Residual Disease in Early Breast Cancer

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Todays Updates

T-DXd Reduces Residual Disease in Early Breast Cancer

Neoadjuvant trastuzumab deruxtecan combination therapy reduces the residual cancer burden in high-risk early breast cancer, even if a pathologic complete response is not achieved, shows analysis.

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Obesity and low muscle mass and/or cardiometabolic comorbidities impede physical functioning more than obesity alone in individuals with or at risk for knee osteoarthritis.

An experimental drug from Revolution Medicines that nearly doubled survival time for patients with advanced pancreas cancer in clinical trials comes with a high rate of...

Primary care clinicians with higher diagnostic confidence are adopting emerging blood-based Alzheimer’s disease tests, raising questions about training, access, and appropriate use.

Higher levels of non-estrogen hormones, along with stress and elevated BMI, are linked to earlier breast development in girls.

Metabolic bariatric surgery is tied to higher risks for multiple micronutrient deficiencies and metabolic complications than GLP-1 receptor agonist therapy.

Novo Nordisk beat first-quarter profit forecasts and nudged up its full-year outlook on Wednesday, helped by stronger-than-expected sales of its new weight-loss pill in the...

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Constipation Linked to Greater Weight Loss on Semaglutide

Patients on semaglutide who experienced constipation had greater weight loss than those without constipation, and genes could be at play.

Capecitabine Extends PFS in Oesophagogastric Cancer

Maintenance therapy with capecitabine prolongs progression-free survival in patients with advanced oesophagogastric adenocarcinoma after first-line chemotherapy.

GLP-1 Drugs May Modestly Raise Optic Neuropathy Risk in T2D

GLP-1 therapy is linked to a modestly increased risk for nonarteritic anterior ischemic optic neuropathy compared with SGLT2 inhibitors in veterans with type 2 diabetes.

Postop Anorectal Morbidity Notable After Bariatric Surgery

Patients undergoing bariatric surgery experience high rates of new-onset benign anal disorders, with constipation more common after sleeve gastrectomy and diarrhea after gastric bypass.

Too Much, Too Little Exercise Tied to Higher Risk for OA

The fact that upper and lower limits of physical activity are linked to osteoarthritis isn’t surprising, but messaging for patients might take into account the type of physical activity they’re doing.

Early Knee OA Lifestyle Program Fails to Stop Progression

Despite requiring substantial resources, lifestyle programs are unlikely to be successful without including a strong behavioral change component, one commenter noted.

Weight-loss Revolution Sparks New Appetite for Aesthetics Firms

Aesthetic firms are betting that a growing pool of patients experiencing loose skin and facial volume loss from GLP-1 obesity drugs will fuel a new wave of demand, as the...

Gastric Bypass Leads to Diabetes Remission

Laparoscopic one anastomosis gastric bypass achieves sustained diabetes remission in most patients with type 2 diabetes and obesity over 10 years of follow-up.

Biomarkers May Guide Tailored Interventions in Obesity

Nutritional and metabolic biomarkers may aid in the early detection of obesity risk, guide precise interventions, and support tailored diets to improve metabolic health.

Gastric Ring Add-On May Aid Weight Loss After Surgery

A ring-augmented one anastomosis gastric bypass achieves greater weight loss than standard surgery in patients with recurrent weight gain or suboptimal outcomes after sleeve gastrectomy.

Oral Acromegaly Drug Performing Well in First Few Patients

Initial real-world results of patients receiving paltusotine suggest reduced symptoms and good tolerability, while a phase 3 trial finds no interaction with levothyroxine.

MASLD Risk May Be Higher in Men Who Eat More Red Meat

Red meat intake showed no overall association with MASLD risk, but higher daily consumption (75-90 g) was linked to increased risk in men.

Childhood Trauma Tied to Gestational Diabetes Risk

Women with prior adverse childhood experiences may face a higher risk for gestational diabetes, with the risk rising with each additional adverse experience, a meta-analysis of 11 studies shows.

Food Insecurity and Poverty May Raise MASLD Risk in US

People who do not have enough food to eat or who live below the poverty level are more likely to develop MASLD, and this risk is higher in non-Hispanic White individuals.

FDA Proposes End to Mass GLP-1 Compounding

The agency appears to leave a loophole for patient-specific formulations.

‘Cyborg’ Islet Cells and Potential New Diabetes Therapies

Researchers combined electronic sensors with human islet cells to create living ‘cyborg’ organoids transmitting troves of previously unseen data on islet cell function.

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