Should we stop taking thiazides to prevent kidney stones?

Published Date: 08 Mar 2023

"Thiazide is the standard treatment for calcium stones, so this [new research] has the potential to upset the basket," one observer said.

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Many experts consider prostate cancer one of immunotherapy’s biggest disappointments. But a handful of patients don’t fit that narrative, and researchers are starting to uncover why.

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Schizophrenia: Nighttime Light Tied to Metabolic Dysfunction

Higher vs lower nighttime light exposure is associated with increased risk for obesity, hypertension, and dyslipidemia in patients with schizophrenia, a study suggests.

Transperineal Biopsy IDs Active Surveillance Candidates

Transperineal 3D mapping biopsy may help select patients with low-risk prostate cancer who are most likely to fare well with active surveillance.

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Many experts consider prostate cancer one of immunotherapy’s biggest disappointments. But a handful of patients don’t fit that narrative, and researchers are starting to uncover why.

Latest News

Researchers identify a new subphenotype of obesity marked by fast gastric emptying, low GLP-1 levels, and greater postmeal hunger that is tied to substantially greater weight loss with tirzepatide.

A new review finds that pregnancy among trans men is real but still poorly studied, leaving clinicians without clear evidence-based guidance.

The prevalence of obesity classes 4 and 5 in US adults has more than tripled since 2000, a study finds.

Exercise vs no treatment/usual care may slightly reduce pain and improve physical function in adults with hip osteoarthritis, but the effects may not be clinically meaningful, per an updated review.

A systematic review supports broader genetic testing for childhood short stature, helping clinicians replace idiopathic diagnoses with molecular causes.

Calcium supplementation may not add to the benefits of osteoporosis medications in older women with adequate calcium intake, but a low protein intake is linked to attenuated effects.

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Lilly Announces More Next-gen Obesity Drug Data, Plans Q1 2027 FDA Application

Eli Lilly said on Thursday that two more Phase 3 trials of its experimental obesity drug retatrutide showed positive results and it plans to submit ⁠an application to the...

Efforts Address Immune Suppression in Islet Cell Transplants

Updates suggest progress in the development of less-toxic regimens, and in gene editing to eliminate the need for immune suppression entirely.

Faricimab Reduces Shots, Improves Vision for Retinal Disease

In two studies in retinal disease, faricimab shows improved vision and a reduced injection burden in people who switched from first-generation drugs.

Food Addiction Can Derail Success After Bariatric Surgery

Following bariatric surgery, women with food addiction report a higher intake of ultraprocessed foods, greater anxiety, lower physical activity, and less favorable weight-loss outcomes.

Will Semaglutide Prices Drop After 2026 Patent Expirations?

As patents expire, generic injectable semaglutide could become available at a fraction of current branded prices — around $28-$140 per person-year — in about 162 countries by the end of 2026.

Helping Patients With Diabetes Utilize Technology

Helping patients overcome fear or anxiety around continuous glucose monitoring may be a hurdle.

Novo Sues Lilly, Claiming Misleading Ads in Weight-loss Drug Battle

Novo Nordisk sued rival Eli Lilly in a U.S. federal court on Tuesday, accusing the U.S. drugmaker of false advertising in claiming its weight-loss medicines outperform...

Global Trial to Test Lifestyle Plus Metabolic Tx in Dementia

A $100 million global trial will investigate whether adding a metabolism-targeting therapy to multidomain lifestyle intervention further reduces the risk of cognitive decline in older adults at risk for dementia.

Compounded GLP-1s Still Widespread Despite Shortage Fix

The compounded GLP-1 market continues, even though some suppliers lack sterile-compounding licenses or have faced disciplinary action, and many add ingredients such as B vitamins.

Alcohol and Marijuana Use in Type 1 Diabetes: What to Know

People with type 1 diabetes are just as likely to use substances as the rest of the population, so they need to be aware of the risks and how to mitigate them.

Semaglutide Tied to Lower Risk for Adult-Onset Seizure

In adults with type 2 diabetes, semaglutide initiation was associated with roughly half the risk for adult-onset seizure compared with other glucose-lowering medications — a protective effect that appeared independent of blood sugar or weight control.

Glucose, A1c Mediate Obesity-Pancreatic Cancer Link

Higher BMI, waist size, and waist-hip ratio are linked to an increased risk for pancreatic cancer, and part of the association is explained by poor glycaemic control, a study finds.

Once-Daily Prednisolone Shows Promise for Hypoadrenalism

In a small study, once-daily prednisolone outperformed hydrocortisone for bone and cardiometabolic outcomes in patients with adrenal insufficiency.

Kidney Disease Hits Early, Hard in Kids With Spina Bifida

A population-based study finds that children with spina bifida are more likely than their peers in the general population to develop chronic kidney disease and ESRD — and to do so at younger ages.

Visceral Belly Fat Can Make You Age Faster, Experts Warn

Higher visceral fat is linked to accelerated biological aging in middle-aged adults, independent of other adiposity measures and lifestyle factors.

India Approves Novo Nordisk's Obesity Drug Wegovy for Fatty Liver Disease

Danish drugmaker Novo Nordisk said on Friday that India's drug regulator has approved its ⁠obesity drug Wegovy for the treatment of metabolic dysfunction-associated...

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