Should we stop taking thiazides to prevent kidney stones?

Published Date: 08 Mar 2023

"Thiazide is the standard treatment for calcium stones, so this [new research] has the potential to upset the basket," one observer said.

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Jazz Seeks Second-Line Lurbinectedin SCLC Withdrawal

The planned label change follows failure of lurbinectedin to improve overall survival in the phase 3 postmarketing trial; the first-line maintenance indication remains unaffected.

Latest News

Women with overweight or obesity BMI trajectories during childhood are less likely to give birth in adulthood than those with average BMI trajectories.

Noninvasive measures of belly fat and insulin resistance independently predict the presence and severity of intestinal metaplasia.

Bariatric surgery volumes have fallen sharply since 2022, yet quality improvements have kept complication rates low despite rising patient complexity.

A longitudinal study found that obesity and high alcohol consumption consistently increased diabetes risk, whereas low-to-moderate alcohol consumption added little risk in people without obesity.

Prebiotic sodas are marketed as a gut- and calorie-friendly alternative to regular soda, but the health claims are often misleading.

Rhythm Pharmaceuticals said on Tuesday its experimental weekly injectable drug helped reduce body weight in ⁠patients with a rare form of obesity caused by damage to the...

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Childhood Adversity Shapes Reproductive Health in Women

Childhood adversity is linked to higher odds of infertility, preterm birth, and small-for-gestational-age birth in women.

GLP-1s, Hypertensive Disorders of Pregnancy: No Clear Link

Exposure to GLP-1 receptor agonists before or early in pregnancy is not linked to an increased risk for hypertensive disorders of pregnancy.

Annual BMI Gain Linked to Prediabetes Risk in Women

Women of reproductive age whose BMI increases gradually over a year face an increased risk of developing prediabetes.

Some Herbal Supplements Show Metabolic Benefits in MASLD

A meta-analysis of 123 trials shows that some herbal supplements offer modest, limited benefits in metabolic dysfunction-associated steatotic liver disease.

Analysis-Obesity Battle Heats Up Again as Novo Claws Way Back Into Race With Lilly

LONDON, Aug 3 - Novo Nordisk investors have found little cause for optimism during a bruising two-year period of profit warnings, leadership upheaval and a sliding share...

Body Fat Beats BMI in Predicting Fracture Risk on AI Therapy

For women taking aromatase inhibitors for early-stage breast cancer, a high body fat percentage may raise the risk for vertebral fracture, regardless of BMI.

Sleep Coaching May Benefit Some Adults With T1D

In adults with T1D and short or irregular sleep, 12 weeks of sleep coaching via phone can improve sleep, ease diabetes-related stress, and lower blood sugar in those with suboptimal A1c levels.

Novel Oral GLP-1 Agonist Boosts Glycemic Control in T2D

In patients with type 2 diabetes inadequately controlled with metformin, adding a novel nonpeptide oral GLP-1 receptor agonist to metformin boosts glycemic control.

Lower Income Affects Pancreatic Cancer Tx, Survival

Lower household income is linked to less treatment and worse survival in patients with localised pancreatic adenocarcinoma, a Dutch study shows.

Who 'Owns' Long-Term TED Management in the Biologic Era?

Targeted biologics and multidisciplinary care are reshaping the management of patients with thyroid eye disease. But who should be leading this care and how? Medscape would like to hear from you about how often you see TED, your biggest clinical challenges, and which treatments you rely on most.

Remote HIIT Sustains Weight Loss in Adolescents

A remotely supervised high-intensity interval training program helped adolescents with obesity lose weight and improve fitness, with benefits lasting at least a year after sessions ended.

Machine Learning Model Boosts Genetic Prediction of T1D Risk

A machine learning model improves prediction of type 1 diabetes risk compared with a conventional genetic risk model, particularly in people without high-risk human leukocyte antigen haplotypes.

Rising, Falling Fat Mass Both Move Endotrophin Levels

Circulating endotrophin rises with fat gain and falls with fat loss, showing promise as a biomarker of body fat changes and a potential target for reducing obesity-linked health risks.

When Temperatures Climb, Hypoglycemia Risk Rises in T1D

An analysis of nearly 33 million continuous glucose monitoring readings links hotter temperatures to more frequent hypoglycemia in adults with type 1 diabetes.

Physical Activity Boosts Self-Esteem in Obesity

Women with obesity who completed supervised physical activity programs — whether face-to-face or digital — showed marked improvements in self-esteem and body image, with most gains emerging in the first month and persisting 3 months later.

Brazil Greenlights Five New Injectable Diabetes Drugs

Brazil's health regulator said ⁠it approved five new injectable GLP-1 drugs for diabetes and obesity treatment, ⁠following the expiration ⁠of Ozempic’s patent in ‌the country.

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