Epigenetics, predictive signals of satiety and obesity

US Fertility Rates Drop to Record Low in 2025 as Births Fall

The U.S. fertility rate hit a record low last year, extending a nearly two-decade decline, provisional ⁠data from the Centers for Disease Control and Prevention showed on...

Testosterone May Lower Fat in Older Women After Hip Fracture

Combining exercise and topical testosterone therapy may shift some visceral adipose tissue into less dangerous subcutaneous fat in older women after a hip fracture.

Soleno Withdraws EU Rare Disease Drug Application Ahead of Takeover

Soleno has voluntarily withdrawn its EU marketing ⁠application for a rare metabolic disorder drug following acquirer Neurocrine's plans to sharpen focus ⁠on the US market.

Aspirin After Colon Cancer Surgery: Who Benefits?

Aspirin reduces the risk for colorectal cancer in high-risk groups, such as Lynch syndrome, but shows no benefit in the general population.

Decade-Long Health Benefits Seen After Sleeve Gastrectomy

Laparoscopic sleeve gastrectomy leads to substantial weight loss, improved quality of life, and high patient satisfaction among most adults with severe obesity even after 10 years.

Nuanced Sexual and Pelvic Floor Effects of GLP-1s on Women

Emerging research and anecdotal reports suggest that the weight-loss drugs may cause vulvar and urogenital changes.

Levothyroxine Discontinuation Safe for Many Older Adults

About 1 in 4 overall and two thirds of those taking doses of 50 µg/d or lower were able to come off the treatment while maintaining adequate thyroid function for 1 year.

Patients With Acromegaly Have Higher Risk for Cancer

Patients with acromegaly show a significantly higher risk for cancer than matched control individuals from the general population, with the risk being evident even 5 years before diagnosis.

APHRODITE Model May Improve Care in Male Infertility

A new classification framework introduces structured phenotyping to guide hormonal therapy in male infertility, addressing long-standing reliance on empirical treatment approaches.

Novo Nordisk Launches Higher-dose Wegovy in the United States

Novo Nordisk said on Tuesday that it has made ⁠a higher-dose version of its blockbuster weight-loss drug Wegovy ⁠available across the United States.

Weight Loss After Tirzepatide Varies by Prior Weight Change

Tirzepatide produced notable weight loss in real-world settings, but patients with prior weight loss experienced smaller additional reductions than those without.

Continuous Glucose Monitoring Expands in Type 2 Diabetes

Continuous glucose monitoring is expanding beyond type 1 diabetes, offering detailed glycemic insights that may support earlier intervention in patients with type 2 diabetes.

Can Oestrogen Patches Replace LHRH Agonists for Prostate Tx?

Transdermal oestradiol patches are non-inferior to luteinising hormone-releasing hormone agonists for metastasis free survival in locally advanced prostate cancer, a study shows.

Prior Bariatric Surgery Lowers Postop Risk Over GLP-1s

Another Pregnancy Can Worsen Insulin Sensitivity Over Time

In parous women, an additional pregnancy is linked to a selective decline in whole-body insulin sensitivity over 10 years, with no clear changes in beta-cell function or blood glucose levels.

US FDA Clarifies Policies on Compounding Of GLP-1 Medicines

The U.S. Food and Drug Administration on Wednesday clarified its policies on compounded versions of ⁠popular GLP-1 drugs, signaling tighter limits on their production as...