Preventing Gene Editing-Related Off-Target Injury Through Long-Read Genomic Integrity Assessment

Speciality: Gene & Cell Therapy


Speaker:

Sandosh Arumugam | HCP

Description:

Gene editing technologies, such as CRISPR, are revolutionising medicine and biotechnology. But a major concern is off-target injury—unexpected changes in the genome that can have unintended consequences. To address this, scientists are now using long-read genomic integrity assessment. Unlike traditional short-read sequencing, long-read methods provide a more complete picture of genetic changes, helping to detect off-target effects more accurately. By thoroughly analysing the genome before and after editing, researchers can ensure greater safety and effectiveness. This approach is paving the way for safer gene therapies and advancements in personalised medicine. With continuous improvements in genomic assessment, the future of gene editing looks increasingly secure.

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