This meeting will cover the latest on the genetic etiology of metabolic dysfunction-associated steatohepatitis (MASH), metabolic and inflammatory drivers of the disease, preclinical modeling of the disease, non-invasive markers for diagnosis, and existing and emerging therapeutics. The meeting will be held jointly with the Keystone Symposium on Obesity and Adipose Tissue to encourage cross-disciplinary insights and collaborations toward understanding underlying mechanisms of how obesity leads
This is a synergistic pairing, given that lipodystrophy has long been known to promote severe MAFLD and ways to reduce overall obesity are also being tried for MAFLD, such as with bariatric surgery and now GLP-1 and dual GLP-1/GIP agonists. Joint sessions on human genetics and therapeutics across MASH and obesity will facilitate interaction between endocrinologists, hepatologists, adipose and liver biologists for synergy
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