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Quiz on Cracking CML: Overcoming TKI Resistance in Modern Management

Dear Doctors, participate in the exciting and educational quiz on Cracking CML: Overcoming TKI Resistance in Modern Management, designed specifically for healthcare professionals. This quiz aims to enhance your understanding of chronic myelogenous leukemia (CML), focusing on the latest strategies for overcoming tyrosine kinase inhibitor (TKI) resistance, the role of genetic mutations, and emerging treatment options. As the management of CML continues to evolve, your expertise in recognizing resistance patterns and adapting treatment plans is essential for optimizing patient outcomes. By participating, you will reinforce your knowledge and stay up-to-date with the cutting-edge advancements in CML care. Let’s explore key concepts and clinical practices to ensure we are equipped to provide the best care for our patients. Participate now!

1. What is the most common mechanism of resistance to tyrosine kinase inhibitors (TKIs) in patients with CML?

2. Which of the following is the recommended approach for a patient with CML showing suboptimal response to first-line TKI therapy?

3. Which second-generation TKI is most effective against BCR-ABL1 mutations, except for the T315I mutation?

4. What is the primary indication for using ponatinib in patients with CML?

5. What is the optimal approach for monitoring treatment response in patients with CML?

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