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Quiz on Endocrine Pancreas Disorders

Dear Doctor, Participate in this fun and interesting quiz on Endocrine Pancreas Disorders. The endocrine pancreas, comprised of the islets of Langerhans, plays a crucial role in regulating blood glucose homeostasis and other vital functions. Disorders of the endocrine pancreas can result in a spectrum of clinical manifestations, ranging from hypoglycemia (as seen in insulinomas) to hyperglycemia (as in diabetes mellitus secondary to chronic pancreatitis) and various hormonal excess syndromes caused by neuroendocrine tumors (NETs). These NETs, while relatively rare, can secrete a variety of hormones, leading to diverse and sometimes challenging clinical presentations. Accurate diagnosis often requires a combination of clinical evaluation, biochemical testing, and imaging studies. Management strategies vary depending on the specific disorder but may include medical therapy, surgical resection, or other interventions to control hormone secretion and alleviate symptoms. Participate now.

1. 55-year-old patient with a history of chronic pancreatitis presents with new-onset diabetes mellitus. Which of the following statements BEST describes the underlying pathophysiology?

2. A patient presents with recurrent episodes of hypoglycemia, often occurring before breakfast or after exercise. Laboratory tests reveal elevated levels of insulin and C-peptide during a hypoglycemic episode. Which of the following is the MOST likely diagnosis?

3. A patient with multiple endocrine neoplasia type 1 (MEN1) presents with recurrent peptic ulcers and diarrhea. Which of the following pancreatic endocrine tumors is MOST likely responsible for these symptoms?

4. A 62-year-old patient with a history of type 2 diabetes presents with a rapidly progressing skin rash characterized by erythema, blistering, and crusting. Laboratory tests reveal elevated levels of glucagon. Which of the following is the MOST likely underlying cause?

5. A patient presents with watery diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). Which of the following pancreatic endocrine tumors is MOST likely responsible?

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